Ndufv1 MGI Mouse Gene Detail - MGI:107851 - NADH:ubiquinone oxidoreductase core subunit V1

Symbol

Ndufv1
Name

NADH:ubiquinone oxidoreductase core subunit V1
Synonyms

24 kDa (FP)

Feature Type

protein coding gene
IDs

MGI:107851
NCBI Gene: 17995
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr19:4057499-4062755 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 3.72 cM
Mapping Data

4 experiments

SNPs within 2kb

143 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107851	protein coding gene	Chr19:4057384-4062806 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024640	protein coding gene	Chr19:826191-831447 (-)
A/J	MGP_AJ_G0024608	protein coding gene	Chr19:786544-791800 (-)
AKR/J	MGP_AKRJ_G0024579	protein coding gene	Chr19:816304-821560 (-)
BALB/cJ	MGP_BALBcJ_G0024606	protein coding gene	Chr19:797558-802814 (-)
C3H/HeJ	MGP_C3HHeJ_G0024374	protein coding gene	Chr19:816701-821957 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025054	protein coding gene	Chr19:834871-840127 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022483	protein coding gene	Chr19:750813-756182 (-)
CAST/EiJ	MGP_CASTEiJ_G0023846	protein coding gene	Chr19:828757-834012 (-)
CBA/J	MGP_CBAJ_G0024345	protein coding gene	Chr19:915801-921057 (-)
DBA/2J	MGP_DBA2J_G0024473	protein coding gene	Chr19:764273-769529 (-)
FVB/NJ	MGP_FVBNJ_G0024440	protein coding gene	Chr19:777296-782534 (-)
LP/J	MGP_LPJ_G0024560	protein coding gene	Chr19:826430-831686 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024471	protein coding gene	Chr19:870395-875651 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025102	protein coding gene	Chr19:809192-814448 (-)
PWK/PhJ	MGP_PWKPhJ_G0023593	protein coding gene	Chr19:802589-807815 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023399	protein coding gene	Chr19:806466-811723 (-)
WSB/EiJ	MGP_WSBEiJ_G0023909	protein coding gene	Chr19:802087-807342 (-)

Human Ortholog

NDUFV1, NADH:ubiquinone oxidoreductase core subunit V1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NDUFV1, NADH:ubiquinone oxidoreductase core subunit V1
Synonyms

CI-51K, CI51KD, MC1DN4, UQOR1
Links

HGNC:7716

NCBI Gene ID: 4723

neXtProt AC: NX_P49821

UniProt: P49821
Chr Location

11q13.2; chr11:67605653-67612554 (+) GRCh38

MGI Vertebrate Homology

Ndufv1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NDUFV1
Gene Tree

Ndufv1

Diseases

1 with human NDUFV1 associations

				Human Disease	Mouse Models
				nuclear type mitochondrial complex I deficiency 4 IDs nuclear type mitochondrial complex I deficiency 4 DOID:0112082 OMIM:618225

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

8
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

27
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

926
Tissues

153
cDNA Data

267
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ndufv1

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All Sequences

85
RefSeq

2
UniProt

8
CCDS

CCDS29410.1

Ensembl

ENSMUSG00000037916 (Evidence)
NCBI Gene

17995

			Length	Strain/Species	Flank
genomic	17995	NCBI Gene Model \| MGI Sequence Detail	5257	C57BL/6J	± kb
transcript	NM_133666	RefSeq \| MGI Sequence Detail	1608	ZRU/MplStud
polypeptide	Q91YT0	UniProt \| EBI \| MGI Sequence Detail	464	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000011104 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

(term hierarchy)
PDB

6G2J, 6G72, 6ZR2, 6ZTQ, 7AK5, 7AK6, 7B93, 7PSA, 8C2S, 8CA3, 8CA4, 8CA5, 8OLT, 8OM1, 8PW5, 8PW6, 8PW7, 8RGP, 8RGQ, 8RGR, 8RGT
EC

7.1.1.2
InterPro Domains

IPR050837 Complex I 51 kDa subunit

IPR001949 NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site

IPR011538 NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain

IPR037225 NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily

IPR019575 NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain

IPR037207 NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily

IPR011537 NADH ubiquinone oxidoreductase, F subunit
GlyGen

Q91YT0 1 site, 1 O-linked glycan (1 site)

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All nucleic 272

cDNA 267

Primer pair 4

Other 1

Microarray probesets 4

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MGD-MRK-36428

Summaries

All 58

Developmental Gene Expression 9

Gene Ontology 15

Phenotypes 10
Earliest

J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
Latest

J:355679 Vercellino I, et al., SCAF1 drives the compositional diversity of mammalian respirasomes. Nat Struct Mol Biol. 2024 Jul;31(7):1061-1071

TSS for Ndufv1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157433	Chr19:4062738-4062749 (-)	11 bp
Tssr157432	Chr19:4062656-4062736 (-)	59 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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