Gpr18 MGI Mouse Gene Detail - MGI:107859 - G protein-coupled receptor 18

Symbol

Gpr18
Name

G protein-coupled receptor 18

Feature Type

protein coding gene
IDs

MGI:107859
NCBI Gene: 110168
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr14:122148846-122153300 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 65.86 cM
Mapping Data

2 experiments

SNPs within 2kb

210 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107859	protein coding gene	Chr14:122148665-122153300 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021665	protein coding gene	Chr14:119788767-119793106 (-)
A/J	MGP_AJ_G0021625	protein coding gene	Chr14:115131700-115136027 (-)
AKR/J	MGP_AKRJ_G0021601	protein coding gene	Chr14:118860936-118865266 (-)
BALB/cJ	MGP_BALBcJ_G0021631	protein coding gene	Chr14:115679378-115683728 (-)
C3H/HeJ	MGP_C3HHeJ_G0021409	protein coding gene	Chr14:118751000-118755324 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022071	protein coding gene	Chr14:124383565-124387892 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019609	protein coding gene	Chr14:111009783-111013851 (-)
CAST/EiJ	MGP_CASTEiJ_G0020924	protein coding gene	Chr14:116663085-116667251 (-)
CBA/J	MGP_CBAJ_G0021377	protein coding gene	Chr14:129115615-129119943 (-)
DBA/2J	MGP_DBA2J_G0021500	protein coding gene	Chr14:114995897-115000230 (-)
FVB/NJ	MGP_FVBNJ_G0021478	protein coding gene	Chr14:113346799-113351135 (-)
LP/J	MGP_LPJ_G0021568	protein coding gene	Chr14:120706209-120710547 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021505	protein coding gene	Chr14:134118564-134122894 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022094	protein coding gene	Chr14:118438205-118442471 (-)
PWK/PhJ	MGP_PWKPhJ_G0020668	protein coding gene	Chr14:112053037-112057203 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020506	protein coding gene	Chr14:114632570-114636704 (-)
WSB/EiJ	MGP_WSBEiJ_G0020980	protein coding gene	Chr14:119127872-119132199 (-)

Human Ortholog

GPR18, G protein-coupled receptor 18

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR18, G protein-coupled receptor 18
Synonyms

DRV2
Links

HGNC:4472

NCBI Gene ID: 2841

neXtProt AC: NX_Q14330

UniProt: Q14330
Chr Location

13q32.3; chr13:99254732-99261744 (-) GRCh38

MGI Vertebrate Homology

Gpr18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPR18
Gene Tree

Gpr18

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

4
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

20 strains or lines available

Mice homozygous for a knock-out allele exhibit a reduction in CD8-positive, alpha-beta T cell number and CD8-positive, gamma-delta intraepithelial T cell number. Mice homozygous for a different knock-out allele exhibit increased susceptibility to E. coli infection and diminished response to RvD2.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

15

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpr18

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS27342.1

Ensembl

ENSMUSG00000050350 (Evidence)
NCBI Gene

110168

			Length	Strain/Species	Flank
genomic	110168	NCBI Gene Model \| MGI Sequence Detail	4455	C57BL/6J	± kb
transcript	NM_182806	RefSeq \| MGI Sequence Detail	1424	ZRU/MplStud
polypeptide	Q8K1Z6	UniProt \| EBI \| MGI Sequence Detail	331	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001430 N-arachidonyl glycine receptor

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR028335 G protein-coupled receptor 18 orphan

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q8K1Z6 2 sites

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All nucleic 16

Genomic 1

cDNA 15

Microarray probesets 3

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MGD-MRK-36436

Summaries

All 38

Gene Ontology 4

Phenotypes 14
Earliest

J:37412 Samuelson LC, et al., Mapping of the novel G protein-coupled receptor Gpr18 to distal mouse chromosome 14. Mamm Genome. 1996 Dec;7(12):920-1
Latest

J:343270 Fitzgerald H, et al., Resolvin D2-G-Protein Coupled Receptor 18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging. Am J Pathol. 2023 Dec;193(12):1953-1968

TSS for Gpr18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130305	Chr14:122153393-122153398 (-)	-96 bp
Tssr130304	Chr14:122153284-122153304 (-)	6 bp
Tssr130303	Chr14:122153219-122153275 (-)	53 bp
Tssr130302	Chr14:122153186-122153205 (-)	104 bp
Tssr130301	Chr14:122153150-122153159 (-)	145 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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