Ssrp1 MGI Mouse Gene Detail - MGI:107912 - structure specific recognition protein 1

Symbol

Ssrp1
Name

structure specific recognition protein 1
Synonyms

Hmg1-rs1, Hmgi-rs3, Hmgox, T160

Feature Type

protein coding gene
IDs

MGI:107912
NCBI Gene: 20833
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:84867578-84877453 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 49.45 cM
Mapping Data

7 experiments

SNPs within 2kb

244 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107912	protein coding gene	Chr2:84867519-84877453 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025920	protein coding gene	Chr2:85746315-85756190 (+)
A/J	MGP_AJ_G0025894	protein coding gene	Chr2:82422097-82431985 (+)
AKR/J	MGP_AKRJ_G0025864	protein coding gene	Chr2:84555833-84565660 (+)
BALB/cJ	MGP_BALBcJ_G0025891	protein coding gene	Chr2:82552725-82562624 (+)
C3H/HeJ	MGP_C3HHeJ_G0025650	protein coding gene	Chr2:84783495-84793874 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026337	protein coding gene	Chr2:88400302-88410177 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023739	protein coding gene	Chr2:79251220-79261223 (+)
CAST/EiJ	MGP_CASTEiJ_G0025111	protein coding gene	Chr2:85337978-85347862 (+)
CBA/J	MGP_CBAJ_G0025631	protein coding gene	Chr2:91555034-91565405 (+)
DBA/2J	MGP_DBA2J_G0025762	protein coding gene	Chr2:81959123-81969025 (+)
FVB/NJ	MGP_FVBNJ_G0025725	protein coding gene	Chr2:81216370-81226367 (+)
LP/J	MGP_LPJ_G0025850	protein coding gene	Chr2:85536734-85546449 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025755	protein coding gene	Chr2:93871699-93881602 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026393	protein coding gene	Chr2:84801671-84811568 (+)
PWK/PhJ	MGP_PWKPhJ_G0024855	protein coding gene	Chr2:81805570-81815743 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024659	protein coding gene	Chr2:84927499-84937375 (+)
WSB/EiJ	MGP_WSBEiJ_G0025181	protein coding gene	Chr2:85463423-85473294 (+)

Human Ortholog

SSRP1, structure specific recognition protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SSRP1, structure specific recognition protein 1
Synonyms

FACT, FACT80, T160
Links

HGNC:11327

NCBI Gene ID: 6749

neXtProt AC: NX_Q08945

UniProt: Q08945
Chr Location

11q12.1; chr11:57325986-57335892 (-) GRCh38

MGI Vertebrate Homology

Ssrp1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SSRP1
Gene Tree

Ssrp1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

47
Chemically induced (other)

1
Gene trapped

39
Targeted

7
Genomic Mutations

3 involving Ssrp1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Disruption of this gene is lethal resulting in death at some point between implantation and E5.5.

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

777
Tissues

68
cDNA Data

25
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SSRP1

Xenbase ssrp1

ZFIN ssrp1a, ssrp1b

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All Sequences

73
RefSeq

12
UniProt

3
CCDS

CCDS38165.1

Ensembl

ENSMUSG00000027067 (Evidence)
NCBI Gene

20833

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027067	Ensembl Gene Model \| MGI Sequence Detail	9876	C57BL/6J	± kb
transcript	ENSMUST00000168266	Ensembl \| MGI Sequence Detail	2721	Not Applicable
polypeptide	ENSMUSP00000127058	Ensembl \| MGI Sequence Detail	708	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015663 FACT complex subunit SSRP1

(term hierarchy)
InterPro Domains

IPR048985 FACT complex subunit SSRP1, C-terminal domain

IPR048993 FACT complex subunit SSRP1-like, first PH domain

IPR000969 FACT complex subunit SSRP1/POB3

IPR035417 FACT complex subunit SSRP1/POB3, N-terminal PH domain

IPR009071 High mobility group box domain

IPR036910 High mobility group box domain superfamily

IPR013719 Histone chaperone RTT106/FACT complex subunit SPT16-like, middle domain

IPR011993 PH-like domain superfamily

IPR050454 RTT106/SSRP1 Histone Chaperone/FACT Complex

IPR024954 SSRP1, dimerization domain

IPR038167 SSRP1 domain superfamily

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All nucleic 30

Genomic 4

cDNA 25

Primer pair 1

Microarray probesets 5

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MGD-MRK-10749, MGD-MRK-10799, MGD-MRK-28178, MGD-MRK-36492, MGI:2139516

Summaries

All 60

Developmental Gene Expression 9

Gene Ontology 8

Phenotypes 17
Earliest

J:11384 Shirakata M, et al., HMG1-related DNA-binding protein isolated with V-(D)-J recombination signal probes. Mol Cell Biol. 1991 Sep;11(9):4528-36
Latest

J:348833 Goswami I, et al., FACT maintains nucleosomes during transcription and stem cell viability in adult mice. EMBO Rep. 2022 Apr 5;23(4):e53684

TSS for Ssrp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18718	Chr2:84867513-84867549 (+)	-47 bp
Tssr18719	Chr2:84867556-84867646 (+)	23 bp
Tssr18720	Chr2:84867792-84867874 (+)	255 bp
Tssr18721	Chr2:84868057-84868072 (+)	487 bp
Tssr18722	Chr2:84870088-84870124 (+)	2,528 bp
Tssr18723	Chr2:84871266-84871303 (+)	3,707 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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