About   Help   FAQ
Tial1 Gene Detail
Summary
  • Symbol
    Tial1
  • Name
    Tia1 cytotoxic granule-associated RNA binding protein-like 1
  • Synonyms
    5330433G13Rik, mTIAR, TIAR
  • Feature Type
    protein coding gene
  • IDs
    MGI:107913
    NCBI Gene: 21843
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:128041501-128063441 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 70.20 cM, cytoband F4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    304 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107913
 protein coding gene Chr7:128041496-128063450 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033083
 protein coding gene Chr7:132868420-132891689 (-)
A/J MGP_AJ_G0033065
 protein coding gene Chr7:129294217-129316131 (-)
AKR/J MGP_AKRJ_G0032997
 protein coding gene Chr7:132686079-132708124 (-)
BALB/cJ MGP_BALBcJ_G0033066
 protein coding gene Chr7:128960545-128982334 (-)
C3H/HeJ MGP_C3HHeJ_G0032780
 protein coding gene Chr7:132561597-132589313 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033576
 protein coding gene Chr7:138051393-138073307 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030548
 protein coding gene Chr7:130464344-130486341 (-)
CAST/EiJ MGP_CASTEiJ_G0032110
 protein coding gene Chr7:124352210-124376240 (-)
CBA/J MGP_CBAJ_G0032753
 protein coding gene Chr7:142779491-142804157 (-)
DBA/2J MGP_DBA2J_G0032905
 protein coding gene Chr7:127277156-127299203 (-)
FVB/NJ MGP_FVBNJ_G0032858
 protein coding gene Chr7:127145946-127168720 (-)
LP/J MGP_LPJ_G0032999
 protein coding gene Chr7:134342522-134365609 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032890
 protein coding gene Chr7:143784202-143820135 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033595
 protein coding gene Chr7:131641567-131663378 (-)
PWK/PhJ MGP_PWKPhJ_G0031816
 protein coding gene Chr7:120296333-120316894 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031662
 protein coding gene Chr7:118448906-118470762 (-)
WSB/EiJ MGP_WSBEiJ_G0032221
 protein coding gene Chr7:132617396-132639609 (-)



Homology
more
  • Human Ortholog
    TIAL1, TIA1 cytotoxic granule associated RNA binding protein like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIAL1, TIA1 cytotoxic granule associated RNA binding protein like 1
  • Synonyms
    TCBP, TIAR
  • Links
    NCBI Gene ID: 7073
    neXtProt AC: NX_Q01085
    UniProt: Q01085

  • Chr Location
    10q26.11; chr10:119571802-119597029 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 4 genetic backgrounds
    2 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit partial embryonic lethality and reduced postnatal survival, reduced embryonic and postnatal body weight, and male and female sterility. Infertility is owed to a substantial decrease in the survival of primordial germ cells atthe genital ridge.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    39
  • cDNA Data
    115
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030846 Ensembl Gene Model | MGI Sequence Detail 21941 C57BL/6J ±  kb
    transcript ENSMUST00000106226 Ensembl | MGI Sequence Detail 4451 Not Applicable  
    polypeptide ENSMUSP00000101833 Ensembl | MGI Sequence Detail 392 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 121
      Genomic 4
      cDNA 115
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36493, MGI:1915328, MGI:2142105
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 13
      Gene Ontology 12
      Phenotypes 16
    • Earliest
      J:36106 Beck AR, et al., Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR. Nucleic Acids Res. 1996 Oct 1;24(19):3829-35
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory