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Lrig1 Gene Detail
Summary
  • Symbol
    Lrig1
  • Name
    leucine-rich repeats and immunoglobulin-like domains 1
  • Synonyms
    Img, LIG-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107935
    NCBI Gene: 16206
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:94581510-94677139 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 43.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2403 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107935
 protein coding gene Chr6:94581510-94677205 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031065
 protein coding gene Chr6:96371808-96469231 (-)
A/J MGP_AJ_G0031034
 protein coding gene Chr6:92713487-92810775 (-)
AKR/J MGP_AKRJ_G0030965
 protein coding gene Chr6:95258745-95354364 (-)
BALB/cJ MGP_BALBcJ_G0031045
 protein coding gene Chr6:92665012-92764705 (-)
C3H/HeJ MGP_C3HHeJ_G0030663
 protein coding gene Chr6:89058562-89154388 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031504
 protein coding gene Chr6:98792460-98888078 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028670
 protein coding gene Chr6:90665386-90762621 (-)
CAST/EiJ MGP_CASTEiJ_G0030152
 protein coding gene Chr6:95465948-95562798 (-)
CBA/J MGP_CBAJ_G0030731
 protein coding gene Chr6:102561121-102656270 (-)
DBA/2J MGP_DBA2J_G0030884
 protein coding gene Chr6:91861735-91957509 (-)
FVB/NJ MGP_FVBNJ_G0030838
 protein coding gene Chr6:91077580-91173818 (-)
LP/J MGP_LPJ_G0030964
 protein coding gene Chr6:96351037-96447334 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030872
 protein coding gene Chr6:106512481-106609700 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031531
 protein coding gene Chr6:95128494-95235481 (-)
PWK/PhJ MGP_PWKPhJ_G0029868
 protein coding gene Chr6:90875071-90971663 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029697
 protein coding gene Chr6:94065569-94161080 (-)
WSB/EiJ MGP_WSBEiJ_G0030236
 protein coding gene Chr6:95600316-95695915 (-)



Homology
more
  • Human Ortholog
    LRIG1, leucine rich repeats and immunoglobulin like domains 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRIG1, leucine rich repeats and immunoglobulin like domains 1
  • Synonyms
    LIG-1, LIG1
  • Links
    NCBI Gene ID: 26018
    neXtProt AC: NX_Q96JA1
    UniProt: Q96JA1

  • Chr Location
    3p14.1; chr3:66378797-66501263 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 5 alleles in 9 genetic backgrounds
    23 phenotypes from multigenic genotypes
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice developed psoriasiform epidermal hyperplasia. Homozygotes exhibit hair follicle, epidermis, vertebral, eye and hearing abnormalities, decreased body size and fat amount, and increased susceptibility to bacterial infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    945
  • Tissues
    165
  • cDNA Data
    112
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030029 Ensembl Gene Model | MGI Sequence Detail 95630 C57BL/6J ±  kb
    transcript ENSMUST00000204645 Ensembl | MGI Sequence Detail 4849 Not Applicable  
    polypeptide ENSMUSP00000144963 Ensembl | MGI Sequence Detail 1091 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000009914 leucine-rich repeats and immunoglobulin-like domains protein 1
      (term hierarchy)
    • InterPro Domains
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR013098 Immunoglobulin I-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003599 Immunoglobulin subtype
      IPR003598 Immunoglobulin subtype 2
      IPR001611 Leucine-rich repeat
      IPR050467 Leucine-rich repeat and fibronectin type-III domain-containing
      IPR032675 Leucine-rich repeat domain superfamily
      IPR000372 Leucine-rich repeat N-terminal domain
      IPR003591 Leucine-rich repeat, typical subtype
    • GlyGen
      P70193 7 sites, 6 N-linked glycans (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 119
      cDNA 112
      Primer pair 4
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36515
    References
    more
    • Summaries
      All 138
      Developmental Gene Expression 33
      Gene Ontology 4
      Phenotypes 86
    • Earliest
      J:35380 Suzuki Y, et al., cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains. J Biol Chem. 1996 Sep 13;271(37):22522-7
    • Latest
      J:354454 De Vincenti AP, et al., Lrig1 regulates cell fate specification of glutamatergic neurons via FGF-driven Jak2/Stat3 signaling in cortical progenitors. Development. 2024 Sep 1;151(17):dev202879
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory