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Tfb2m Gene Detail
Summary
  • Symbol
    Tfb2m
  • Name
    transcription factor B2, mitochondrial
  • Synonyms
    Hkp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107937
    NCBI Gene: 15278
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:179355620-179373832 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 83.56 cM, cytoband H3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    582 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107937
 protein coding gene Chr1:179355617-179373870 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016859
 protein coding gene Chr1:185893687-185913997 (-)
A/J MGP_AJ_G0016837
 protein coding gene Chr1:178413364-178432439 (-)
AKR/J MGP_AKRJ_G0016803
 protein coding gene Chr1:183730363-183748467 (-)
BALB/cJ MGP_BALBcJ_G0016795
 protein coding gene Chr1:179034995-179053207 (-)
C3H/HeJ MGP_C3HHeJ_G0016620
 protein coding gene Chr1:184459755-184479202 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017259
 protein coding gene Chr1:191903515-191935512 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014966
 protein coding gene Chr1:169405452-169425242 (-)
CAST/EiJ MGP_CASTEiJ_G0016201
 protein coding gene Chr1:183766135-183785565 (-)
CBA/J MGP_CBAJ_G0016594
 protein coding gene Chr1:199065640-199088576 (-)
DBA/2J MGP_DBA2J_G0016700
 protein coding gene Chr1:177249461-177268356 (-)
FVB/NJ MGP_FVBNJ_G0016696
 protein coding gene Chr1:175328475-175347583 (-)
LP/J MGP_LPJ_G0016774
 protein coding gene Chr1:187171543-187191240 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016727
 protein coding gene Chr1:206216077-206236645 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017295
 protein coding gene Chr1:183448564-183468227 (-)
PWK/PhJ MGP_PWKPhJ_G0015989
 protein coding gene Chr1:176331877-176350229 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015765
 protein coding gene Chr1:182412176-182430279 (-)
WSB/EiJ MGP_WSBEiJ_G0016264
 protein coding gene Chr1:183685218-183703388 (-)



Homology
more
  • Human Ortholog
    TFB2M, transcription factor B2, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TFB2M, transcription factor B2, mitochondrial
  • Synonyms
    Hkp1, h-mtTFB, h-mtTFB2, hTFB2M, mtTFB2
  • Links
    NCBI Gene ID: 64216
    neXtProt AC: NX_Q9H5Q4
    UniProt: Q9H5Q4

  • Chr Location
    1q44; chr1:246540561-246566261 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1017
  • Tissues
    81
  • cDNA Data
    73
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026492 Ensembl Gene Model | MGI Sequence Detail 18213 C57BL/6J ±  kb
    transcript ENSMUST00000027769 Ensembl | MGI Sequence Detail 2449 Not Applicable  
    polypeptide ENSMUSP00000027769 Ensembl | MGI Sequence Detail 396 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000016268 dimethyladenosine transferase 2, mitochondrial
      (term hierarchy)
    • EC
      2.1.1.-
    • InterPro Domains
      IPR020598 Ribosomal RNA adenine methylase transferase, N-terminal
      IPR001737 Ribosomal RNA adenine methyltransferase KsgA/Erm
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 73
      Primer pair 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36517
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:319888 Son JS, et al., Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling. EBioMedicine. 2022 Jan 23;76:103842
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory