Cct6a Gene Detail

Summary

• Symbol
  Cct6a
• Name
  chaperonin containing TCP1 subunit 6A
• Synonyms
  Cct6, Cctz-1, chaperonin containing TCP-1

• Feature Type
  protein coding gene
• IDs
  MGI:107943
  NCBI Gene: 12466
• Alliance
  gene page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  Chr5:129864420-129875284 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, 68.26 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  476 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107943	protein coding gene	Chr5:129864062-129875284 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015615	unclassified non-coding RNA gene	Chr5:133908537-133920986 (+)
A/J	MGP_AJ_G0015591	unclassified non-coding RNA gene	Chr5:128279507-128290482 (+)
AKR/J	MGP_AKRJ_G0015555	unclassified non-coding RNA gene	Chr5:132452015-132464235 (+)
BALB/cJ	MGP_BALBcJ_G0015553	unclassified non-coding RNA gene	Chr5:129628386-129638905 (+)
C3H/HeJ	MGP_C3HHeJ_G0015375	unclassified non-coding RNA gene	Chr5:133004661-133016372 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016007	unclassified non-coding RNA gene	Chr5:139041501-139052608 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013741	unclassified non-coding RNA gene	Chr5:122667187-122678429 (+)
CAST/EiJ	MGP_CASTEiJ_G0014931	unclassified non-coding RNA gene	Chr5:132302489-132318947 (+)
CBA/J	MGP_CBAJ_G0015356	unclassified non-coding RNA gene	Chr5:144451479-144463218 (+)
DBA/2J	MGP_DBA2J_G0015450	unclassified non-coding RNA gene	Chr5:128241933-128253728 (+)
FVB/NJ	MGP_FVBNJ_G0015457	unclassified non-coding RNA gene	Chr5:127335787-127346438 (+)
LP/J	MGP_LPJ_G0015531	unclassified non-coding RNA gene	Chr5:134418318-134429080 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015480	unclassified non-coding RNA gene	Chr5:147795350-147806115 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016049	unclassified non-coding RNA gene	Chr5:132137367-132148389 (+)
PWK/PhJ	MGP_PWKPhJ_G0014716	unclassified non-coding RNA gene	Chr5:127168784-127180467 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014504	unclassified non-coding RNA gene	Chr5:129697489-129708115 (+)
WSB/EiJ	MGP_WSBEiJ_G0015035	unclassified non-coding RNA gene	Chr5:132836393-132851502 (+)

Homology

• Human Ortholog
  CCT6A, chaperonin containing TCP1 subunit 6A

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  CCT6A, chaperonin containing TCP1 subunit 6A
  
• Synonyms
  CCT6, Cctz, CCT-zeta, CCT-zeta-1, HTR3, MoDP-2, TCP-1-zeta, TCP20, TCPZ, TTCP20
• Links
  HGNC:1620

  NCBI Gene ID: 908

  neXtProt AC: NX_P40227

  UniProt: P40227

  
  
• Chr Location
  7p11.2; chr7:56051685-56063989 (+)  GRCh38

---

• MGI Vertebrate Homology
  Cct6a stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: CCT6A
• Gene Tree
  Cct6a
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  13 phenotype references
  

• All Mutations and Alleles
  30
• Chemically induced (other)
  1
• Endonuclease-mediated
  3
• Gene trapped
  25
• Radiation induced
  1
• Genomic Mutations
  2 involving Cct6a
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  22 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  24
• GO References
  9

Expression

• Assay Results
  718
• Tissues
  1
• cDNA Data
  37
• Literature Summary
  3

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA CCT6A
  Xenbase cct6a

Sequences &
Gene Models

• All Sequences
  88
• RefSeq
  2
• UniProt
  7

• Ensembl
  ENSMUSG00000029447 (Evidence)
• NCBI Gene
  12466

Representative Sequences			Length	Strain/Species
genomic	12466	NCBI Gene Model | MGI Sequence Detail	10865	C57BL/6J
transcript	NM_009838	RefSeq | MGI Sequence Detail	2302	C57BL/6
polypeptide	P80317	UniProt | EBI | MGI Sequence Detail	531	Not Applicable

Protein
Information

• UniProt
  7 Sequences
• Protein Ontology
  PR:000005154 T-complex protein 1 subunit zeta
  (term hierarchy)
• InterPro Domains
  IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
  IPR002423 Chaperonin Cpn60/GroEL/TCP-1 family
  IPR002194 Chaperonin TCP-1, conserved site
  IPR027409 GroEL-like apical domain superfamily
  IPR027413 GroEL-like equatorial domain superfamily
  IPR012722 T-complex protein 1, zeta subunit
  IPR053374 TCP-1 chaperonin-containing T-complex
  IPR027410 TCP-1-like chaperonin intermediate domain superfamily
• GlyGen
  P80317 1 site, 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 40

  cDNA 38

  Primer pair 2

  
  

  Microarray probesets 3

Other
Accession IDs

MGD-MRK-36523

References

• Summaries
  All 42

  Developmental Gene Expression 3

  Gene Ontology 9

  Phenotypes 13
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Cct6a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49015	Chr5:129864054-129864122 (+)	-332 bp
Tssr49016	Chr5:129864429-129864452 (+)	21 bp
Tssr49017	Chr5:129864454-129864477 (+)	46 bp
Tssr49018	Chr5:129868863-129868875 (+)	4,449 bp