Zfp36l1 MGI Mouse Gene Detail - MGI:107946 - zinc finger protein 36, C3H type-like 1

Symbol

Zfp36l1
Name

zinc finger protein 36, C3H type-like 1
Synonyms

Brf1, cMG1, D530020L18Rik, TIS11b

Feature Type

protein coding gene
IDs

MGI:107946
NCBI Gene: 12192
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr12:80154534-80159787 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 36.46 cM
Mapping Data

2 experiments

SNPs within 2kb

104 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107946	protein coding gene	Chr12:80154528-80159787 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019885	protein coding gene	Chr12:80446678-80452178 (-)
A/J	MGP_AJ_G0019843	protein coding gene	Chr12:77540717-77546047 (-)
AKR/J	MGP_AKRJ_G0019818	protein coding gene	Chr12:79645542-79652874 (-)
BALB/cJ	MGP_BALBcJ_G0019822	protein coding gene	Chr12:77792566-77798928 (-)
C3H/HeJ	MGP_C3HHeJ_G0019628	protein coding gene	Chr12:80123261-80129139 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020274	protein coding gene	Chr12:82808495-82813763 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017893	protein coding gene	Chr12:74549419-74554644 (-)
CAST/EiJ	MGP_CASTEiJ_G0019178	protein coding gene	Chr12:74980150-74984187 (-)
CBA/J	MGP_CBAJ_G0019599	protein coding gene	Chr12:86045905-86055056 (-)
DBA/2J	MGP_DBA2J_G0019714	protein coding gene	Chr12:77162951-77167094 (-)
FVB/NJ	MGP_FVBNJ_G0019700	protein coding gene	Chr12:75974063-75979340 (-)
LP/J	MGP_LPJ_G0019786	protein coding gene	Chr12:80379121-80384997 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019739	protein coding gene	Chr12:89076036-89082144 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020309	protein coding gene	Chr12:79174483-79180363 (-)
PWK/PhJ	MGP_PWKPhJ_G0018944	protein coding gene	Chr12:71545378-71550954 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018738	protein coding gene	Chr12:73662324-73668918 (-)
WSB/EiJ	MGP_WSBEiJ_G0019231	protein coding gene	Chr12:79797294-79804825 (-)

Human Ortholog

ZFP36L1, ZFP36 ring finger protein like 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZFP36L1, ZFP36 ring finger protein like 1
Synonyms

Berg36, BRF1, cMG1, ERF-1, ERF1, RNF162B, TIS11B
Links

HGNC:1107

NCBI Gene ID: 677

neXtProt AC: NX_Q07352

UniProt: Q07352
Chr Location

14q24.1; chr14:68787655-68796253 (-) GRCh38

MGI Vertebrate Homology

Zfp36l1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ZFP36L1
Gene Tree

Zfp36l1

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

24 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotypes from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

5
Targeted

8
Genomic Mutations

1 involving Zfp36l1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display embryonic lethality with failure of chorioallantoic fusion.

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All GO Annotations

108
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1501
Tissues

163
cDNA Data

143
Literature Summary

17

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zfp36l1

ZFIN zfp36l1a, zfp36l1b

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All Sequences

40
RefSeq

2
UniProt

5
CCDS

CCDS26010.1

Ensembl

ENSMUSG00000021127 (Evidence)
NCBI Gene

12192

			Length	Strain/Species	Flank
genomic	12192	NCBI Gene Model \| MGI Sequence Detail	5254	C57BL/6J	± kb
transcript	NM_007564	RefSeq \| MGI Sequence Detail	2984	C57BL/6
polypeptide	P23950	UniProt \| EBI \| MGI Sequence Detail	338	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017640 mRNA decay activator protein ZFP36L1

(term hierarchy)
InterPro Domains

IPR045877 RNA-binding protein ZFP36-like

IPR007635 Tis11B-like protein, N-terminal

IPR000571 Zinc finger, CCCH-type

IPR036855 Zinc finger, CCCH-type superfamily

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All nucleic 148

cDNA 144

Primer pair 2

Other 2

Microarray probesets 4

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MGD-MRK-36526, MGI:1925964, MGI:2140615, MGI:2145053

Summaries

All 79

Developmental Gene Expression 17

Diseases 1

Gene Ontology 18

Phenotypes 25
Earliest

J:33288 Varnum BC, et al., The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol Cell Biol. 1991 Mar;11(3):1754-8
Latest

J:357284 Lo Giudice Q, et al., Developmental emergence of first- and higher-order thalamic neuron molecular identities. Development. 2024 Sep 15;151(18)

TSS for Zfp36l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116856	Chr12:80160004-80160006 (-)	-218 bp
Tssr116855	Chr12:80159776-80159793 (-)	2 bp
Tssr116854	Chr12:80157230-80157244 (-)	2,550 bp
Tssr116853	Chr12:80157216-80157227 (-)	2,565 bp
Tssr116852	Chr12:80157144-80157169 (-)	2,630 bp
Tssr116851	Chr12:80157092-80157099 (-)	2,691 bp
Tssr116850	Chr12:80156975-80156987 (-)	2,806 bp
Tssr116849	Chr12:80156927-80156943 (-)	2,852 bp
Tssr116848	Chr12:80156795-80156823 (-)	2,978 bp
Tssr116847	Chr12:80156686-80156729 (-)	3,079 bp
Tssr116846	Chr12:80156548-80156572 (-)	3,227 bp
Tssr116845	Chr12:80156501-80156522 (-)	3,275 bp
Tssr116844	Chr12:80156307-80156353 (-)	3,457 bp
Tssr116843	Chr12:80155621-80155645 (-)	4,154 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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