Rhob MGI Mouse Gene Detail - MGI:107949 - ras homolog family member B

Symbol

Rhob
Name

ras homolog family member B
Synonyms

Arhb

Feature Type

protein coding gene
IDs

MGI:107949
NCBI Gene: 11852
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:8547661-8550009 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 3.88 cM
Mapping Data

2 experiments

SNPs within 2kb

139 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107949	protein coding gene	Chr12:8547661-8550009 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019585	protein coding gene	Chr12:5547758-5549980 (-)
A/J	MGP_AJ_G0019552	protein coding gene	Chr12:5388371-5390592 (-)
AKR/J	MGP_AKRJ_G0019522	protein coding gene	Chr12:5750916-5753138 (-)
BALB/cJ	MGP_BALBcJ_G0019527	protein coding gene	Chr12:5475007-5477228 (-)
C3H/HeJ	MGP_C3HHeJ_G0019333	protein coding gene	Chr12:5532066-5534288 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019976	protein coding gene	Chr12:5697102-5699324 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017601	protein coding gene	Chr12:5200502-5202735 (-)
CAST/EiJ	MGP_CASTEiJ_G0018888	protein coding gene	Chr12:5570615-5572835 (-)
CBA/J	MGP_CBAJ_G0019304	protein coding gene	Chr12:6247900-6250122 (-)
DBA/2J	MGP_DBA2J_G0019417	protein coding gene	Chr12:5348368-5350590 (-)
FVB/NJ	MGP_FVBNJ_G0019408	protein coding gene	Chr12:5313226-5315448 (-)
LP/J	MGP_LPJ_G0019488	protein coding gene	Chr12:5568840-5571062 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019441	protein coding gene	Chr12:6034960-6037182 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020015	protein coding gene	Chr12:5500335-5502556 (-)
PWK/PhJ	MGP_PWKPhJ_G0018654	protein coding gene	Chr12:5395739-5397961 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018445	protein coding gene	Chr12:5511939-5514160 (-)
WSB/EiJ	MGP_WSBEiJ_G0018939	protein coding gene	Chr12:5539452-5541673 (-)

Human Ortholog

RHOB, ras homolog family member B

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RHOB, ras homolog family member B
Synonyms

ARH6, ARHB, MST081, MSTP081, RHOH6
Links

HGNC:668

NCBI Gene ID: 388

neXtProt AC: NX_P62745

UniProt: P62745
Chr Location

2p24.1; chr2:20447074-20449440 (+) GRCh38

MGI Vertebrate Homology

Rhob stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RHOB
Gene Tree

Rhob

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Phenotype Summary

9 phenotypes from 1 allele in 2 genetic backgrounds
1 phenotype from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

5
Targeted

2
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in increased incidence of DMBA-induced skin tumors.

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All GO Annotations

55
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

813
Tissues

69
cDNA Data

176
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RHOB

Xenbase rhob

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All Sequences

42
RefSeq

2
UniProt

3
CCDS

CCDS25799.1

Ensembl

ENSMUSG00000054364 (Evidence)
NCBI Gene

11852

			Length	Strain/Species	Flank
genomic	11852	NCBI Gene Model \| MGI Sequence Detail	2349	C57BL/6J	± kb
transcript	NM_007483	RefSeq \| MGI Sequence Detail	2366	C57BL/6
polypeptide	P62746	UniProt \| EBI \| MGI Sequence Detail	196	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013977 Rho-related GTP-binding protein RhoB

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR003578 Small GTPase Rho

IPR005225 Small GTP-binding protein domain

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All nucleic 182

Genomic 4

cDNA 176

Primer pair 2

Microarray probesets 3

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MGD-MRK-36529, MGI:2144717

Summaries

All 91

Developmental Gene Expression 15

Gene Ontology 17

Phenotypes 23
Earliest

J:113699 Adamson P, et al., Post-translational modifications of p21rho proteins. J Biol Chem. 1992 Oct 5;267(28):20033-8
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Rhob:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115715	Chr12:8550001-8550017 (-)	0 bp
Tssr115714	Chr12:8548666-8548682 (-)	1,335 bp
Tssr115713	Chr12:8548280-8548313 (-)	1,712 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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