Sebox MGI Mouse Gene Detail - MGI:108012

Symbol

Sebox
Name

SEBOX homeobox
Synonyms

OG9, Og9x

Feature Type

protein coding gene
IDs

MGI:108012
NCBI Gene: 18292
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:78394328-78395907 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.74 cM
Mapping Data

1 experiment

SNPs within 2kb

106 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108012	protein coding gene	Chr11:78394273-78395907 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018783	protein coding gene	Chr11:79523419-79525053 (+)
A/J	MGP_AJ_G0018749	protein coding gene	Chr11:76474535-76476169 (+)
AKR/J	MGP_AKRJ_G0018719	protein coding gene	Chr11:78778197-78779831 (+)
BALB/cJ	MGP_BALBcJ_G0018723	protein coding gene	Chr11:76877645-76879279 (+)
C3H/HeJ	MGP_C3HHeJ_G0018536	protein coding gene	Chr11:78825143-78826777 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019174	protein coding gene	Chr11:81990720-81992354 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016809	protein coding gene	Chr11:73444693-73446302 (+)
CAST/EiJ	MGP_CASTEiJ_G0018090	protein coding gene	Chr11:79281875-79283504 (+)
CBA/J	MGP_CBAJ_G0018507	protein coding gene	Chr11:85600717-85602351 (+)
DBA/2J	MGP_DBA2J_G0018615	protein coding gene	Chr11:76049214-76050848 (+)
FVB/NJ	MGP_FVBNJ_G0018605	protein coding gene	Chr11:75639708-75641342 (+)
LP/J	MGP_LPJ_G0018686	protein coding gene	Chr11:80036819-80038453 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018631	protein coding gene	Chr11:85961937-85963571 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019214	protein coding gene	Chr11:79027012-79028646 (+)
PWK/PhJ	MGP_PWKPhJ_G0017861	protein coding gene	Chr11:76845635-76847267 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017652	protein coding gene	Chr11:78642651-78644282 (+)
WSB/EiJ	MGP_WSBEiJ_G0018143	protein coding gene	Chr11:78856348-78857982 (+)

Human Ortholog

SEBOX, SEBOX homeobox

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SEBOX, SEBOX homeobox
Synonyms

OG-9, OG9, OG9X
Links

HGNC:32942

NCBI Gene ID: 645832

neXtProt AC: NX_Q9HB31

UniProt: Q9HB31
Chr Location

17q11.2; chr17:28363506-28365199 (-) GRCh38

MGI Vertebrate Homology

Sebox stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SEBOX
Gene Tree

Sebox

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

3 involving Sebox
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

10 strains or lines available

Adult mice homozygous for a targeted disruption of this gene display normal retinal morphology as well as normal electroretinograms under scotopic and photopic conditions.

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All GO Annotations

4
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

942
Tissues

143
cDNA Data

17
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sebox

ZFIN sebox

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS25107.1

Ensembl

ENSMUSG00000001103 (Evidence)
NCBI Gene

18292

			Length	Strain/Species	Flank
genomic	18292	NCBI Gene Model \| MGI Sequence Detail	1580	C57BL/6J	± kb
transcript	NM_008759	RefSeq \| MGI Sequence Detail	1296	ZRU/MplStud
polypeptide	P70368	UniProt \| EBI \| MGI Sequence Detail	190	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014572 homeobox protein SEBOX

(term hierarchy)
InterPro Domains

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

IPR042223 Homeobox protein SEBOX

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All nucleic 25

Genomic 1

cDNA 17

Primer pair 5

Other 2

Microarray probesets 4

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MGD-MRK-37046

Summaries

All 49

Developmental Gene Expression 12

Gene Ontology 4

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sebox:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103317	Chr11:78392540-78392556 (+)	-1,780 bp
Tssr103318	Chr11:78392567-78392629 (+)	-1,730 bp
Tssr103319	Chr11:78392648-78392665 (+)	-1,671 bp
Tssr103320	Chr11:78392675-78392708 (+)	-1,636 bp
Tssr103321	Chr11:78392999-78393020 (+)	-1,318 bp
Tssr103322	Chr11:78394324-78394329 (+)	-1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24