Uncx MGI Mouse Gene Detail - MGI:108013

Symbol

Uncx
Name

UNC homeobox
Synonyms

Chx4, Uncx4.1

Feature Type

protein coding gene
IDs

MGI:108013
NCBI Gene: 22255
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr5:139529620-139533934 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 78.75 cM
Mapping Data

4 experiments

SNPs within 2kb

94 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108013	protein coding gene	Chr5:139529249-139533934 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030287	protein coding gene	Chr5:144538065-144542707 (+)
A/J	MGP_AJ_G0030256	protein coding gene	Chr5:138408025-138412573 (+)
AKR/J	MGP_AKRJ_G0030188	protein coding gene	Chr5:142717506-142722152 (+)
BALB/cJ	MGP_BALBcJ_G0030273	protein coding gene	Chr5:139648456-139653098 (+)
C3H/HeJ	MGP_C3HHeJ_G0029984	protein coding gene	Chr5:143494777-143499419 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030718	protein coding gene	Chr5:149864726-149869412 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027936	protein coding gene	Chr5:132265723-132270419 (+)
CAST/EiJ	MGP_CASTEiJ_G0029389	protein coding gene	Chr5:142907517-142912194 (+)
CBA/J	MGP_CBAJ_G0029954	protein coding gene	Chr5:156054133-156058649 (+)
DBA/2J	MGP_DBA2J_G0030104	protein coding gene	Chr5:138213318-138218367 (+)
FVB/NJ	MGP_FVBNJ_G0030059	protein coding gene	Chr5:137332237-137336757 (+)
LP/J	MGP_LPJ_G0030190	protein coding gene	Chr5:145146092-145151329 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030090	protein coding gene	Chr5:158693182-158697824 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030758	protein coding gene	Chr5:142534936-142539576 (+)
PWK/PhJ	MGP_PWKPhJ_G0029104	protein coding gene	Chr5:137229144-137233775 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028940	protein coding gene	Chr5:140220584-140225250 (+)
WSB/EiJ	MGP_WSBEiJ_G0029463	protein coding gene	Chr5:143305494-143311874 (+)

Human Ortholog

UNCX, UNC homeobox

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UNCX, UNC homeobox
Synonyms

UNCX4.1
Links

HGNC:33194

NCBI Gene ID: 340260

neXtProt AC: NX_A6NJT0

UniProt: A6NJT0
Chr Location

7p22.3; chr7:1232872-1237326 (+) GRCh38

MGI Vertebrate Homology

Uncx stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: UNCX
Gene Tree

Uncx

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Phenotype Summary

24 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants exhibit severe skeletal defects, including absence of pedicles, transverse processes and proximal ribs. Mutants die around birth from respiratory failure.

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All GO Annotations

17
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1390
Tissues

235
cDNA Data

23
Literature Summary

225

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase uncx

ZFIN uncx

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All Sequences

40
RefSeq

6
UniProt

2
CCDS

CCDS19813.1

Ensembl

ENSMUSG00000029546 (Evidence)
NCBI Gene

22255

			Length	Strain/Species	Flank
genomic	22255	NCBI Gene Model \| MGI Sequence Detail	4315	C57BL/6J	± kb
transcript	NM_013702	RefSeq \| MGI Sequence Detail	2095	C57BL/6
polypeptide	O08934	UniProt \| EBI \| MGI Sequence Detail	530	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017103 homeobox protein unc-4

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

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All nucleic 63

Genomic 1

cDNA 25

Primer pair 7

Other 30

Microarray probesets 3

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MGD-MRK-37047

Summaries

All 252

Developmental Gene Expression 225

Gene Ontology 9

Phenotypes 7
Earliest

J:33997 Bulleit RF, et al., A novel gene selectively expressed in the cerebellum. Neurosci Lett. 1996 May 10;209(2):93-6
Latest

J:348800 Clark JF, et al., Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development. Genes Dev. 2024 Jun 4;

TSS for Uncx:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49517	Chr5:139529617-139529626 (+)	2 bp
Tssr49518	Chr5:139529644-139529659 (+)	32 bp
Tssr49519	Chr5:139529666-139529687 (+)	57 bp
Tssr1728	Chr5:139533617-139533628 (+)	4,003 bp
Tssr49520	Chr5:139533699-139533710 (+)	4,085 bp
Tssr49521	Chr5:139533725-139533737 (+)	4,111 bp
Tssr49522	Chr5:139533750-139533759 (+)	4,135 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24