Prkar2a MGI Mouse Gene Detail - MGI:108025 - protein kinase, cAMP dependent regulatory, type II alpha

Symbol

Prkar2a
Name

protein kinase, cAMP dependent regulatory, type II alpha
Synonyms

1110061A24Rik, RII(alpha)

Feature Type

protein coding gene
IDs

MGI:108025
NCBI Gene: 19087
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr9:108569342-108627643 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 59.63 cM
Mapping Data

2 experiments

SNPs within 2kb

1361 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108025	protein coding gene	Chr9:108566513-108627643 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035311	protein coding gene	Chr9:110668680-110738445 (+)
A/J	MGP_AJ_G0035290	protein coding gene	Chr9:106611138-106672930 (+)
AKR/J	MGP_AKRJ_G0035222	protein coding gene	Chr9:109286381-109352927 (+)
BALB/cJ	MGP_BALBcJ_G0035284	protein coding gene	Chr9:106306743-106369084 (+)
C3H/HeJ	MGP_C3HHeJ_G0034994	protein coding gene	Chr9:109686121-109750246 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035804	protein coding gene	Chr9:113692188-113756529 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032702	protein coding gene	Chr9:104032520-104086699 (+)
CAST/EiJ	MGP_CASTEiJ_G0034305	protein coding gene	Chr9:109643631-109713661 (+)
CBA/J	MGP_CBAJ_G0034962	protein coding gene	Chr9:117706005-117779590 (+)
DBA/2J	MGP_DBA2J_G0035123	protein coding gene	Chr9:106067505-106128858 (+)
FVB/NJ	MGP_FVBNJ_G0035071	protein coding gene	Chr9:104834016-104895745 (+)
LP/J	MGP_LPJ_G0035199	protein coding gene	Chr9:110860897-110927330 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035110	protein coding gene	Chr9:119265521-119332166 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035825	protein coding gene	Chr9:109559604-109625005 (+)
PWK/PhJ	MGP_PWKPhJ_G0034012	protein coding gene	Chr9:106396548-106459854 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033847	protein coding gene	Chr9:109630062-109693102 (+)
WSB/EiJ	MGP_WSBEiJ_G0034426	protein coding gene	Chr9:109448280-109518606 (+)

Human Ortholog

PRKAR2A, protein kinase cAMP-dependent type II regulatory subunit alpha

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRKAR2A, protein kinase cAMP-dependent type II regulatory subunit alpha
Synonyms

PKR2, PRKAR2
Links

HGNC:9391

NCBI Gene ID: 5576

neXtProt AC: NX_P13861

UniProt: P13861
Chr Location

3p21.31; chr3:48744591-48847874 (-) GRCh38

MGI Vertebrate Homology

Prkar2a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PRKAR2A
Protein SuperFamily

PK_regulatory
Gene Tree

Prkar2a

Diseases

1 with human PRKAR2A associations

				Human Disease	Mouse Models
				congestive heart failure IDs congestive heart failure DOID:6000 DOID:395 ICD10CM:I50 ICD10CM:I50.9 ICD9CM:428 ICD9CM:428.0 ICD9CM:428.9 MESH:D006333 NCI:C3080 NCI:C50577 UMLS_CUI:C0018801 UMLS_CUI:C0018802

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
13 phenotype references

All Mutations and Alleles

28
Gene trapped

27
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

73 strains or lines available

Homozygous null mice are viable and appear healthy. They have normal growth and no deficits in locomotor activity, muscle strength, or exploratory behavior.

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All GO Annotations

45
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

900
Tissues

133
cDNA Data

17
Literature Summary

16

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prkar2a

ZFIN prkar2ab

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All Sequences

59
RefSeq

2
UniProt

7
CCDS

CCDS23536.1

Ensembl

ENSMUSG00000032601 (Evidence)
NCBI Gene

19087

			Length	Strain/Species	Flank
genomic	19087	NCBI Gene Model \| MGI Sequence Detail	58302	C57BL/6J	± kb
transcript	NM_008924	RefSeq \| MGI Sequence Detail	4973	C57BL/6
polypeptide	P12367	UniProt \| EBI \| MGI Sequence Detail	401	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000013230 cAMP-dependent protein kinase type II-alpha regulatory subunit

(term hierarchy)
PDB

1L6E, 1R2A, 2IZY, 2QVS, 3J4Q, 3J4R
EC

2.7.1.37
InterPro Domains

IPR050503 cAMP-dependent kinase regulatory chain

IPR012198 cAMP-dependent protein kinase regulatory subunit

IPR003117 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain

IPR018488 Cyclic nucleotide-binding, conserved site

IPR000595 Cyclic nucleotide-binding domain

IPR018490 Cyclic nucleotide-binding domain superfamily

IPR014710 RmlC-like jelly roll fold

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All nucleic 25

Genomic 3

cDNA 20

Primer pair 2

Microarray probesets 8

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MGD-MRK-37061, MGI:1913460, MGI:2143017, MGI:2143127

Summaries

All 81

Developmental Gene Expression 16

Gene Ontology 12

Phenotypes 13
Earliest

J:36741 Scott JD, et al., The molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5192-6
Latest

J:301747 London E, et al., Loss of habenular Prkar2a reduces hedonic eating and increases exercise motivation. JCI Insight. 2020 Dec 3;5(23)

TSS for Prkar2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87155	Chr9:108569315-108569392 (+)	12 bp
Tssr87156	Chr9:108569401-108569411 (+)	64 bp
Tssr87157	Chr9:108569489-108569511 (+)	158 bp
Tssr87158	Chr9:108616905-108616909 (+)	47,565 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24