About   Help   FAQ
Atr Gene Detail
Summary
  • Symbol
    Atr
  • Name
    ataxia telangiectasia and Rad3 related
  • Feature Type
    protein coding gene
  • IDs
    MGI:108028
    NCBI Gene: 245000
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:95739650-95833834 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 50.27 cM, cytoband E4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1439 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108028
 protein coding gene Chr9:95739650-95834813 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035139
 protein coding gene Chr9:97005022-97109605 (+)
A/J MGP_AJ_G0035120
 protein coding gene Chr9:93638722-93737073 (+)
AKR/J MGP_AKRJ_G0035052
 protein coding gene Chr9:95907469-96007452 (+)
BALB/cJ MGP_BALBcJ_G0035113
 protein coding gene Chr9:93325820-93421386 (+)
C3H/HeJ MGP_C3HHeJ_G0034823
 protein coding gene Chr9:96339137-96435174 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035633
 protein coding gene Chr9:99783513-99892938 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032534
 protein coding gene Chr9:91462178-91554471 (+)
CAST/EiJ MGP_CASTEiJ_G0034135
 protein coding gene Chr9:96068384-96167768 (+)
CBA/J MGP_CBAJ_G0034791
 protein coding gene Chr9:103257521-103359930 (+)
DBA/2J MGP_DBA2J_G0034953
 protein coding gene Chr9:93164085-93257920 (+)
FVB/NJ MGP_FVBNJ_G0034901
 protein coding gene Chr9:92010887-92103482 (+)
LP/J MGP_LPJ_G0035032
 protein coding gene Chr9:97265249-97368851 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034940
 protein coding gene Chr9:105255642-105363473 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035655
 protein coding gene Chr9:96136697-96234453 (+)
PWK/PhJ MGP_PWKPhJ_G0033842
 protein coding gene Chr9:93319943-93418054 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033677
 protein coding gene Chr9:96141792-96245501 (+)
WSB/EiJ MGP_WSBEiJ_G0034255
 protein coding gene Chr9:96008433-96106444 (+)



Homology
more
  • Human Ortholog
    ATR, ATR serine/threonine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATR, ATR serine/threonine kinase
  • Synonyms
    FCTCS, FRP1, MEC1, SCKL, SCKL1
  • Links
    NCBI Gene ID: 545
    neXtProt AC: NX_Q13535
    UniProt: Q13535

  • Chr Location
    3q23; chr3:142449007-142578733 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Atr mouse models; 5 with human ATR associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    114 phenotypes from 8 alleles in 11 genetic backgrounds
    17 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit early embryonic lethality. Mice heterozygous for a knock-out allele exhibit premature death and increased tumor incidence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    88
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    68
  • cDNA Data
    65
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032409 Ensembl Gene Model | MGI Sequence Detail 94185 C57BL/6J ±  kb
    transcript ENSMUST00000215311 Ensembl | MGI Sequence Detail 8102 Not Applicable  
    polypeptide ENSMUSP00000149953 Ensembl | MGI Sequence Detail 2641 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 66
      Primer pair 5

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-37064
    References
    more
    • Summaries
      All 147
      Developmental Gene Expression 25
      Diseases 1
      Gene Ontology 24
      Phenotypes 57
    • Earliest
      J:35913 Keegan KS, et al., The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes [see comments]. Genes Dev. 1996 Oct 1;10(19):2423-37
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory