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Hyou1 Gene Detail
Summary
  • Symbol
    Hyou1
  • Name
    hypoxia up-regulated 1
  • Synonyms
    140 kDa, Cab140, CBP-140, Grp170, Orp150
  • Feature Type
    protein coding gene
  • IDs
    MGI:108030
    NCBI Gene: 12282
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44290840-44303662 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband B
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    340 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108030
 protein coding gene Chr9:44290787-44303666 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034705
 protein coding gene Chr9:42863842-42876752 (+)
A/J MGP_AJ_G0034686
 protein coding gene Chr9:41667394-41680239 (+)
AKR/J MGP_AKRJ_G0034612
 protein coding gene Chr9:42529979-42542866 (+)
BALB/cJ MGP_BALBcJ_G0034677
 protein coding gene Chr9:41414800-41428126 (+)
C3H/HeJ MGP_C3HHeJ_G0034388
 protein coding gene Chr9:42987813-43000655 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035198
 protein coding gene Chr9:44138190-44151792 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032113
 protein coding gene Chr9:41245642-41257870 (+)
CAST/EiJ MGP_CASTEiJ_G0033710
 protein coding gene Chr9:42833719-42846673 (+)
CBA/J MGP_CBAJ_G0034360
 protein coding gene Chr9:45733596-45746460 (+)
DBA/2J MGP_DBA2J_G0034519
 protein coding gene Chr9:41570289-41583133 (+)
FVB/NJ MGP_FVBNJ_G0034460
 protein coding gene Chr9:40824496-40837775 (+)
LP/J MGP_LPJ_G0034600
 protein coding gene Chr9:43166558-43180315 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034504
 protein coding gene Chr9:47587201-47600820 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035219
 protein coding gene Chr9:42431159-42444043 (+)
PWK/PhJ MGP_PWKPhJ_G0033416
 protein coding gene Chr9:41441012-41454086 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033250
 protein coding gene Chr9:42751541-42766798 (+)
WSB/EiJ MGP_WSBEiJ_G0033823
 protein coding gene Chr9:42470493-42484203 (+)



Homology
more
  • Human Ortholog
    HYOU1, hypoxia up-regulated 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HYOU1, hypoxia up-regulated 1
  • Synonyms
    Grp170, GRP-170, HSP12A, IMD59, ORP-150, ORP150
  • Links
    NCBI Gene ID: 10525
    neXtProt AC: NX_Q9Y4L1
    UniProt: Q9Y4L1

  • Chr Location
    11q23.3; chr11:119044188-119057227 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HYOU1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality. Heterozygous mice display increased susceptibility to induced neuronal cell death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    5
  • cDNA Data
    72
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12282 NCBI Gene Model | MGI Sequence Detail 12823 C57BL/6J ±  kb
    transcript NM_001411631 RefSeq | MGI Sequence Detail 4455 C57BL/6  
    polypeptide Q9JKR6 UniProt | EBI | MGI Sequence Detail 999 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000008853 hypoxia up-regulated protein 1
      (term hierarchy)
    • InterPro Domains
      IPR043129 ATPase, nucleotide binding domain
      IPR018181 Heat shock protein 70, conserved site
      IPR013126 Heat shock protein 70 family
      IPR050451 Heat Shock Protein 70 (HSP70)
      IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
      IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
    • GlyGen
      Q9JKR6 10 sites, 23 N-linked glycans (8 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 73

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37066, MGI:1330846, MGI:2143035
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 3
      Gene Ontology 13
      Phenotypes 15
    • Earliest
      J:29304 Naved AF, et al., CBP-140, a novel endoplasmic reticulum resident Ca(2+)-binding protein with a carboxy-terminal NDEL sequence showed partial homology with 70-kDa heat shock protein (hsp70). Cell Struct Funct. 1995 Apr;20(2):133-41
    • Latest
      J:332218 Sallais J, et al., HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2. JCI Insight. 2022 Dec 8;7(23)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory