Ccna1 MGI Mouse Gene Detail - MGI:108042

Symbol

Ccna1
Name

cyclin A1

Feature Type

protein coding gene
IDs

MGI:108042
NCBI Gene: 12427
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:54952890-54962922 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 26.52 cM
Mapping Data

1 experiment

SNPs within 2kb

442 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108042	protein coding gene	Chr3:54952890-54965055 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027219	protein coding gene	Chr3:53771976-53781993 (-)
A/J	MGP_AJ_G0027179	protein coding gene	Chr3:52106262-52116361 (-)
AKR/J	MGP_AKRJ_G0027149	protein coding gene	Chr3:53176821-53186811 (-)
BALB/cJ	MGP_BALBcJ_G0027192	protein coding gene	Chr3:51957286-51967267 (-)
C3H/HeJ	MGP_C3HHeJ_G0026935	protein coding gene	Chr3:53386986-53397449 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027638	protein coding gene	Chr3:55805183-55815188 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024997	protein coding gene	Chr3:48622727-48632761 (-)
CAST/EiJ	MGP_CASTEiJ_G0026387	protein coding gene	Chr3:53529439-53539460 (-)
CBA/J	MGP_CBAJ_G0026911	protein coding gene	Chr3:57595865-57605842 (-)
DBA/2J	MGP_DBA2J_G0027045	protein coding gene	Chr3:51659116-51669168 (-)
FVB/NJ	MGP_FVBNJ_G0027013	protein coding gene	Chr3:50644850-50654819 (-)
LP/J	MGP_LPJ_G0027157	protein coding gene	Chr3:54476076-54486108 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027031	protein coding gene	Chr3:61707226-61717223 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027696	protein coding gene	Chr3:53093640-53104643 (-)
PWK/PhJ	MGP_PWKPhJ_G0026119	protein coding gene	Chr3:51330975-51341014 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025932	protein coding gene	Chr3:52846618-52856759 (-)
WSB/EiJ	MGP_WSBEiJ_G0026461	protein coding gene	Chr3:53219192-53229159 (-)

Human Ortholog

CCNA1, cyclin A1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCNA1, cyclin A1
Synonyms

CT146
Links

HGNC:1577

NCBI Gene ID: 8900

neXtProt AC: NX_P78396

UniProt: P78396
Chr Location

13q13.3; chr13:36431517-36442870 (+) GRCh38

MGI Vertebrate Homology

Ccna1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCNA1
Protein SuperFamily

Cyclin_A_B_D_E
Gene Tree

Ccna1

Diseases

1 with human CCNA1 associations

				Human Disease	Mouse Models
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 2 alleles in 3 genetic backgrounds
13 phenotypes from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Radiation induced

2
Targeted

6
Genomic Mutations

2 involving Ccna1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null males are infertile due to the arrest of spermatogenesis prior to the first meiotic division. Female mutant mice are fertile.

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All GO Annotations

17
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

796
Tissues

25
cDNA Data

8
Literature Summary

51

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CCNA1

Xenbase ccna1

ZFIN ccna1

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All Sequences

75
RefSeq

33
UniProt

4
CCDS

CCDS17356.1

Ensembl

ENSMUSG00000027793 (Evidence)
NCBI Gene

12427

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027793	Ensembl Gene Model \| MGI Sequence Detail	10033	C57BL/6J	± kb
transcript	ENSMUST00000029368	Ensembl \| MGI Sequence Detail	1560	Not Applicable
polypeptide	ENSMUSP00000029368	Ensembl \| MGI Sequence Detail	421	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005114 cyclin-A1

(term hierarchy)
InterPro Domains

IPR039361 Cyclin

IPR046965 Cyclin A/B-like

IPR032447 Cyclin-A, N-terminal APC/C binding region

IPR004367 Cyclin, C-terminal domain

IPR013763 Cyclin-like domain

IPR036915 Cyclin-like superfamily

IPR006671 Cyclin, N-terminal

IPR048258 Cyclins, cyclin-box

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All nucleic 17

Genomic 1

cDNA 8

Primer pair 6

Other 2

Microarray probesets 3

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MGD-MRK-37078

Summaries

All 115

Developmental Gene Expression 51

Diseases 1

Gene Ontology 7

Phenotypes 23
Earliest

J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
Latest

J:336417 Chong D, et al., Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming. Cell Discov. 2022 Oct 11;8(1):106

TSS for Ccna1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr33295	Chr3:54962922-54962940 (-)	-9 bp
Tssr33294	Chr3:54962899-54962912 (-)	16 bp
Tssr33293	Chr3:54962509-54962548 (-)	393 bp
Tssr33292	Chr3:54962459-54962472 (-)	456 bp
Tssr33291	Chr3:54962404-54962443 (-)	498 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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