Bag1 MGI Mouse Gene Detail - MGI:108047 - BCL2-associated athanogene 1

Symbol

Bag1
Name

BCL2-associated athanogene 1
Synonyms

Rap46

Feature Type

protein coding gene
IDs

MGI:108047
NCBI Gene: 12017
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:40936398-40948294 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 20.67 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

394 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108047	protein coding gene	Chr4:40936398-40948294 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028150	protein coding gene	Chr4:38847074-38858974 (-)
A/J	MGP_AJ_G0028108	protein coding gene	Chr4:37380125-37392022 (-)
AKR/J	MGP_AKRJ_G0028071	protein coding gene	Chr4:38336744-38348667 (-)
BALB/cJ	MGP_BALBcJ_G0028120	protein coding gene	Chr4:37710856-37722756 (-)
C3H/HeJ	MGP_C3HHeJ_G0027848	protein coding gene	Chr4:38876317-38889131 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028561	protein coding gene	Chr4:40280025-40291921 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025902	protein coding gene	Chr4:35032970-35044748 (-)
CAST/EiJ	MGP_CASTEiJ_G0027304	protein coding gene	Chr4:38531906-38544106 (-)
CBA/J	MGP_CBAJ_G0027820	protein coding gene	Chr4:41653795-41665695 (-)
DBA/2J	MGP_DBA2J_G0027964	protein coding gene	Chr4:37299582-37311482 (-)
FVB/NJ	MGP_FVBNJ_G0027931	protein coding gene	Chr4:36634809-36646709 (-)
LP/J	MGP_LPJ_G0028072	protein coding gene	Chr4:38914845-38926745 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027964	protein coding gene	Chr4:44987599-44999496 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028620	protein coding gene	Chr4:38450733-38462633 (-)
PWK/PhJ	MGP_PWKPhJ_G0027023	protein coding gene	Chr4:37303323-37315978 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026850	protein coding gene	Chr4:38144211-38156148 (-)
WSB/EiJ	MGP_WSBEiJ_G0027380	protein coding gene	Chr4:38405416-38417298 (-)

Human Ortholog

BAG1, BAG cochaperone 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BAG1, BAG cochaperone 1
Synonyms

BAG-1, HAP, RAP46
Links

HGNC:937

NCBI Gene ID: 573

neXtProt AC: NX_Q99933

UniProt: Q99933
Chr Location

9p13.3; chr9:33247820-33264720 (-) GRCh38

MGI Vertebrate Homology

Bag1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BAG1
Protein SuperFamily

BAG_1
Gene Tree

Bag1

Diseases

1 with human BAG1 associations

				Human Disease	Mouse Models
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically and radiation induced

1
Endonuclease-mediated

2
Gene trapped

9
Targeted

4
Transgenic

1
Genomic Mutations

1 involving Bag1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display embryonic lethality and liver hypoplasia.

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All GO Annotations

39
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

779
Tissues

56
cDNA Data

139
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bag1

ZFIN bag1

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All Sequences

52
RefSeq

4
UniProt

3
CCDS

CCDS38713.1, CCDS51139.1

Ensembl

ENSMUSG00000028416 (Evidence)
NCBI Gene

12017

			Length	Strain/Species	Flank
genomic	12017	NCBI Gene Model \| MGI Sequence Detail	11897	C57BL/6J	± kb
transcript	NM_001171739	RefSeq \| MGI Sequence Detail	1365	Not Specified
polypeptide	Q60739	UniProt \| EBI \| MGI Sequence Detail	355	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004619 BAG family molecular chaperone regulator 1

(term hierarchy)
PDB

1I6Z, 2LWP, 2M8S
InterPro Domains

IPR003103 BAG domain

IPR036533 BAG domain superfamily

IPR039773 Molecular chaperone regulator BAG

IPR017093 Molecular chaperone regulator BAG-1

IPR000626 Ubiquitin-like domain

IPR029071 Ubiquitin-like domain superfamily

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All nucleic 142

cDNA 139

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-37083

Summaries

All 58

Developmental Gene Expression 9

Gene Ontology 11

Phenotypes 18
Earliest

J:34759 Takayama S, et al., Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell. 1995 Jan 27;80(2):279-84
Latest

J:352269 Inose-Maruyama A, et al., Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion. Cell Stress Chaperones. 2024;29(3):497-509

TSS for Bag1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr41287	Chr4:40948301-40948318 (-)	-16 bp
Tssr41286	Chr4:40948196-40948296 (-)	48 bp
Tssr41285	Chr4:40948184-40948195 (-)	104 bp
Tssr41284	Chr4:40948131-40948150 (-)	153 bp
Tssr41283	Chr4:40948102-40948113 (-)	186 bp
Tssr41282	Chr4:40942857-40942869 (-)	5,431 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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