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Smyd5 Gene Detail
Summary
  • Symbol
    Smyd5
  • Name
    SET and MYND domain containing 5
  • Synonyms
    MGC:29044, NN8-4AG, Rai15, Rrg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108048
    NCBI Gene: 232187
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:85408971-85423417 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.44 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    229 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108048
 protein coding gene Chr6:85408958-85423417 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030953
 protein coding gene Chr6:86598592-86613055 (+)
A/J MGP_AJ_G0030922
 protein coding gene Chr6:83300536-83315133 (+)
AKR/J MGP_AKRJ_G0030850
 protein coding gene Chr6:85712645-85728446 (+)
BALB/cJ MGP_BALBcJ_G0030932
 protein coding gene Chr6:83292605-83307738 (+)
C3H/HeJ MGP_C3HHeJ_G0030778
 protein coding gene Chr6:98718092-98732504 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031392
 protein coding gene Chr6:88983091-88997529 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028577
 protein coding gene Chr6:81574116-81588700 (+)
CAST/EiJ MGP_CASTEiJ_G0030041
 protein coding gene Chr6:85727494-85743224 (+)
CBA/J MGP_CBAJ_G0030619
 protein coding gene Chr6:92472213-92486638 (+)
DBA/2J MGP_DBA2J_G0030772
 protein coding gene Chr6:82583563-82598305 (+)
FVB/NJ MGP_FVBNJ_G0030725
 protein coding gene Chr6:81785908-81800442 (+)
LP/J MGP_LPJ_G0030851
 protein coding gene Chr6:86594193-86608836 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030761
 protein coding gene Chr6:96676880-96691308 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031416
 protein coding gene Chr6:85514701-85529150 (+)
PWK/PhJ MGP_PWKPhJ_G0029756
 protein coding gene Chr6:81518904-81533548 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029584
 protein coding gene Chr6:84370904-84387241 (+)
WSB/EiJ MGP_WSBEiJ_G0030122
 protein coding gene Chr6:85960363-85976052 (+)



Homology
more
  • Human Ortholog
    SMYD5, SMYD family member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMYD5, SMYD family member 5
  • Synonyms
    NN8-4AG, RAI15, RRG1, ZMYND23
  • Links
    NCBI Gene ID: 10322
    neXtProt AC: NX_Q6GMV2
    UniProt: Q6GMV2

  • Chr Location
    2p13.2; chr2:73214222-73227221 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    20
  • cDNA Data
    115
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033706 Ensembl Gene Model | MGI Sequence Detail 14447 C57BL/6J ±  kb
    transcript ENSMUST00000045693 Ensembl | MGI Sequence Detail 2486 Not Applicable  
    polypeptide ENSMUSP00000048537 Ensembl | MGI Sequence Detail 416 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 118
      Genomic 2
      cDNA 115
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-37084, MGI:2141690
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:34386 Shago M, et al., Isolation of a novel retinoic acid-responsive gene by selection of genomic fragments derived from CpG-island-enriched DNA. Mol Cell Biol. 1996 Aug;16(8):4337-48
    • Latest
      J:357730 Miao B, et al., SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma. Cell Res. 2024 Sep;34(9):648-660
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory