Cxcl1 MGI Mouse Gene Detail - MGI:108068 - C-X-C motif chemokine ligand 1

Symbol

Cxcl1
Name

C-X-C motif chemokine ligand 1
Synonyms

Fsp, Gro1, KC, KC/GRO-alpha, Mgsa, N51, Scyb1

Feature Type

protein coding gene
IDs

MGI:108068
NCBI Gene: 14825
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr5:91039100-91040974 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 44.78 cM, cytoband E-F
Mapping Data

15 experiments

SNPs within 2kb

165 from dbSNP Build 142
Strain Annotations

18
RFLP

11

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108068	protein coding gene	Chr5:91039100-91040980 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029731	protein coding gene	Chr5:91983100-91984968 (+)
A/J	MGP_AJ_G0029697	protein coding gene	Chr5:88356388-88358262 (+)
AKR/J	MGP_AKRJ_G0029643	protein coding gene	Chr5:91216449-91218323 (+)
BALB/cJ	MGP_BALBcJ_G0029707	protein coding gene	Chr5:89257869-89259743 (+)
C3H/HeJ	MGP_C3HHeJ_G0029430	protein coding gene	Chr5:91641775-91643649 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030161	protein coding gene	Chr5:95644814-95646688 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027397	protein coding gene	Chr5:84045886-84047719 (+)
CAST/EiJ	MGP_CASTEiJ_G0028840	protein coding gene	Chr5:91002167-91004041 (+)
CBA/J	MGP_CBAJ_G0029400	protein coding gene	Chr5:98941641-98943515 (+)
DBA/2J	MGP_DBA2J_G0029544	protein coding gene	Chr5:88431001-88432875 (+)
FVB/NJ	MGP_FVBNJ_G0029503	protein coding gene	Chr5:87278729-87280603 (+)
LP/J	MGP_LPJ_G0029632	protein coding gene	Chr5:92363337-92365205 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029532	protein coding gene	Chr5:103911598-103913472 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030195	protein coding gene	Chr5:90767517-90769385 (+)
PWK/PhJ	MGP_PWKPhJ_G0028559	protein coding gene	Chr5:87480527-87482359 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028394	protein coding gene	Chr5:90164026-90165859 (+)
WSB/EiJ	MGP_WSBEiJ_G0028919	protein coding gene	Chr5:91212779-91214647 (+)

Human Ortholog

CXCL1, C-X-C motif chemokine ligand 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CXCL1, C-X-C motif chemokine ligand 1
Synonyms

FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1
Links

HGNC:4602

NCBI Gene ID: 2919

neXtProt AC: NX_P09341

UniProt: P09341
Chr Location

4q13.3; chr4:73869393-73871308 (+) GRCh38

Human Ortholog

CXCL2, C-X-C motif chemokine ligand 2
Synonyms

CINC-2a, GRO2, GROb, MGSA-b, MIP2, MIP-2a, MIP2A, SCYB2
Links

HGNC:4603

NCBI Gene ID: 2920

neXtProt AC: NX_P19875

UniProt: P19875
Chr Location

4q13.3; chr4:74097040-74099196 (-) GRCh38

MGI Vertebrate Homology

Cxcl1 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CXCL1, CXCL2
Gene Tree

Cxcl1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Endonuclease-mediated

8
Radiation induced

1
Spontaneous

1
Targeted

1
Transgenic

1
Genomic Mutations

4 involving Cxcl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Targeted mutations in this gene when combine with targeted mutation of Ldlr decreases susceptibility to atherosclerotic lesions.

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All GO Annotations

19
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

796
Tissues

58
cDNA Data

21
Literature Summary

39

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

2
UniProt

3
CCDS

CCDS39143.1

Ensembl

ENSMUSG00000029380 (Evidence)
NCBI Gene

14825

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029380	Ensembl Gene Model \| MGI Sequence Detail	1875	C57BL/6J	± kb
transcript	ENSMUST00000031327	Ensembl \| MGI Sequence Detail	953	Not Applicable
polypeptide	ENSMUSP00000031327	Ensembl \| MGI Sequence Detail	96	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006063 growth-regulated alpha protein

(term hierarchy)
InterPro Domains

IPR039809 Chemokine beta/gamma/delta

IPR001811 Chemokine interleukin-8-like domain

IPR036048 Chemokine interleukin-8-like superfamily

IPR001089 CXC chemokine

IPR018048 CXC chemokine, conserved site

IPR033899 CXC Chemokine domain

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All nucleic 35

cDNA 22

Primer pair 12

Other 1

Microarray probesets 6

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MGD-MRK-12226, MGD-MRK-37105, MGD-MRK-9878

Summaries

All 203

Developmental Gene Expression 39

Gene Ontology 13

Phenotypes 31
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:358349 Ross JL, et al., Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations. Immunity. 2024 Oct 8;

TSS for Cxcl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47215	Chr5:91039093-91039109 (+)	1 bp
Tssr47216	Chr5:91039690-91039701 (+)	596 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24