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Nptn Gene Detail
Summary
  • Symbol
    Nptn
  • Name
    neuroplastin
  • Synonyms
    NP65, Sdfr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108077
    NCBI Gene: 20320
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:58489504-58560162 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.79 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    992 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108077
 protein coding gene Chr9:58489504-58565238 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034893
 protein coding gene Chr9:57880755-57963777 (+)
A/J MGP_AJ_G0034874
 protein coding gene Chr9:56003094-56081901 (+)
AKR/J MGP_AKRJ_G0034803
 protein coding gene Chr9:57302249-57380713 (+)
BALB/cJ MGP_BALBcJ_G0034866
 protein coding gene Chr9:55773823-55851390 (+)
C3H/HeJ MGP_C3HHeJ_G0034576
 protein coding gene Chr9:57787381-57871008 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035385
 protein coding gene Chr9:59494167-59575602 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032296
 protein coding gene Chr9:55275473-55356164 (+)
CAST/EiJ MGP_CASTEiJ_G0033897
 protein coding gene Chr9:57884631-57962697 (+)
CBA/J MGP_CBAJ_G0034547
 protein coding gene Chr9:61588842-61669256 (+)
DBA/2J MGP_DBA2J_G0034706
 protein coding gene Chr9:55853093-55929261 (+)
FVB/NJ MGP_FVBNJ_G0034648
 protein coding gene Chr9:55096412-55173137 (+)
LP/J MGP_LPJ_G0034789
 protein coding gene Chr9:58165312-58244301 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034691
 protein coding gene Chr9:63019051-63103609 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035407
 protein coding gene Chr9:57315860-57398738 (+)
PWK/PhJ MGP_PWKPhJ_G0033601
 protein coding gene Chr9:55919590-55995026 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033436
 protein coding gene Chr9:57604176-57681787 (+)
WSB/EiJ MGP_WSBEiJ_G0034010
 protein coding gene Chr9:57270244-57349707 (+)



Homology
more
  • Human Ortholog
    NPTN, neuroplastin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPTN, neuroplastin
  • Synonyms
    GP55, GP65, np55, np65, SDFR1, SDR1
  • Links
    NCBI Gene ID: 27020
    neXtProt AC: NX_Q9Y639
    UniProt: Q9Y639

  • Chr Location
    15q24.1; chr15:73560014-73634134 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 4 alleles in 5 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal dendritic spine morphology, decreased CNS synapse formation, abnormal CNS synaptic transmission and impaired hearing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    29
  • cDNA Data
    154
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20320 NCBI Gene Model | MGI Sequence Detail 70659 C57BL/6J ±  kb
    transcript NM_001406062 RefSeq | MGI Sequence Detail 2402 C57BL/6  
    polypeptide P97300 UniProt | EBI | MGI Sequence Detail 397 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 155
      cDNA 154
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37114, MGI:2143330
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 30
    • Earliest
      J:36732 Shirozu M, et al., Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method. Genomics. 1996 Nov 1;37(3):273-80
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory