Sypl1 MGI Mouse Gene Detail - MGI:108081

Symbol

Sypl1
Name

synaptophysin like 1
Synonyms

D12Ertd446e, Pan I, Pphn, Sypl

Feature Type

protein coding gene
IDs

MGI:108081
NCBI Gene: 19027
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr12:33003874-33029503 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 13.87 cM, cytoband B2
Mapping Data

4 experiments

SNPs within 2kb

647 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108081	protein coding gene	Chr12:33003874-33029859 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019672	protein coding gene	Chr12:31001234-31026247 (+)
A/J	MGP_AJ_G0019639	protein coding gene	Chr12:30073643-30098805 (+)
AKR/J	MGP_AKRJ_G0019610	protein coding gene	Chr12:31062242-31087404 (+)
BALB/cJ	MGP_BALBcJ_G0019616	protein coding gene	Chr12:30296669-30323474 (+)
C3H/HeJ	MGP_C3HHeJ_G0019420	protein coding gene	Chr12:30904131-30929174 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020063	protein coding gene	Chr12:31925152-31950358 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017688	protein coding gene	Chr12:29368854-29393142 (+)
CAST/EiJ	MGP_CASTEiJ_G0018975	protein coding gene	Chr12:25945010-25972388 (+)
CBA/J	MGP_CBAJ_G0019392	protein coding gene	Chr12:32951050-32978476 (+)
DBA/2J	MGP_DBA2J_G0019505	protein coding gene	Chr12:29898114-29923676 (+)
FVB/NJ	MGP_FVBNJ_G0019496	protein coding gene	Chr12:29687173-29712332 (+)
LP/J	MGP_LPJ_G0019575	protein coding gene	Chr12:31076739-31101898 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019531	protein coding gene	Chr12:32584259-32621963 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020103	protein coding gene	Chr12:30559867-30585067 (+)
PWK/PhJ	MGP_PWKPhJ_G0018742	protein coding gene	Chr12:24663162-24688561 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018530	protein coding gene	Chr12:25184065-25209598 (+)
WSB/EiJ	MGP_WSBEiJ_G0019025	protein coding gene	Chr12:30794896-30820892 (+)

Human Ortholog

SYPL1, synaptophysin like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SYPL1, synaptophysin like 1
Synonyms

H-SP1, SYPL
Links

HGNC:11507

NCBI Gene ID: 6856

neXtProt AC: NX_Q16563

UniProt: Q16563
Chr Location

7q22.3; chr7:106090505-106112589 (-) GRCh38

MGI Vertebrate Homology

Sypl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SYPL1
Gene Tree

Sypl1

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Phenotype Summary

15 phenotypes from 1 allele in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility or sub-fertility associated with asthenozoospermia, sperm flagellar angulation, and abnormal formation and sequestration of saccular elements within the cytoplasmic droplet during late steps of spermiogenesis.

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

22
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

72
RefSeq

10
UniProt

5
CCDS

CCDS25872.1, CCDS25873.1

Ensembl

ENSMUSG00000020570 (Evidence)
NCBI Gene

19027

			Length	Strain/Species	Flank
genomic	19027	NCBI Gene Model \| MGI Sequence Detail	25630	C57BL/6J	± kb
transcript	NM_198710	RefSeq \| MGI Sequence Detail	4615	ZRU/MplStud
polypeptide	O09117	UniProt \| EBI \| MGI Sequence Detail	261	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015891 synaptophysin-like protein 1

(term hierarchy)
InterPro Domains

IPR008253 Marvel domain

IPR001285 Synaptophysin/synaptoporin
GlyGen

O09117 6 sites, 13 N-linked glycans (4 sites), 1 O-linked glycan (1 site)

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All nucleic 27

Genomic 2

cDNA 23

Primer pair 2

Microarray probesets 9

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MGD-MRK-37118, MGI:1196280, MGI:2144783, MGI:2144862, MGI:7482303

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 11
Earliest

J:34608 Haass NK, et al., Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles. J Cell Biol. 1996 Aug;134(3):731-46
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sypl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113168	Chr12:33003854-33003869 (+)	-12 bp
Tssr113169	Chr12:33003873-33003890 (+)	8 bp
Tssr113170	Chr12:33003913-33003935 (+)	50 bp
Tssr113171	Chr12:33004178-33004277 (+)	354 bp
Tssr113172	Chr12:33004279-33004291 (+)	411 bp
Tssr113173	Chr12:33004299-33004305 (+)	428 bp
Tssr113174	Chr12:33004558-33004572 (+)	691 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24