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Bcar1 Gene Detail
Summary
  • Symbol
    Bcar1
  • Name
    breast cancer anti-estrogen resistance 1
  • Synonyms
    Cas, Crkas, p130Cas
  • Feature Type
    protein coding gene
  • IDs
    MGI:108091
    NCBI Gene: 12927
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:112437106-112470441 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.98 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    780 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108091
 protein coding gene Chr8:112437106-112470481 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034145
 protein coding gene Chr8:114520669-114555246 (-)
A/J MGP_AJ_G0034125
 protein coding gene Chr8:109854323-109887540 (-)
AKR/J MGP_AKRJ_G0034052
 protein coding gene Chr8:113073026-113108209 (-)
BALB/cJ MGP_BALBcJ_G0034119
 protein coding gene Chr8:110031747-110064984 (-)
C3H/HeJ MGP_C3HHeJ_G0033830
 protein coding gene Chr8:113803330-113836789 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034639
 protein coding gene Chr8:118523237-118557812 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031581
 protein coding gene Chr8:102823972-102856496 (-)
CAST/EiJ MGP_CASTEiJ_G0033157
 protein coding gene Chr8:113430500-113463603 (-)
CBA/J MGP_CBAJ_G0033803
 protein coding gene Chr8:122603302-122636540 (-)
DBA/2J MGP_DBA2J_G0033959
 protein coding gene Chr8:109128376-109161608 (-)
FVB/NJ MGP_FVBNJ_G0033902
 protein coding gene Chr8:108107157-108140384 (-)
LP/J MGP_LPJ_G0034048
 protein coding gene Chr8:114671198-114705678 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033949
 protein coding gene Chr8:125448890-125484252 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034657
 protein coding gene Chr8:113068864-113102014 (-)
PWK/PhJ MGP_PWKPhJ_G0032859
 protein coding gene Chr8:108726980-108761604 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032699
 protein coding gene Chr8:111719943-111753061 (-)
WSB/EiJ MGP_WSBEiJ_G0033273
 protein coding gene Chr8:113742723-113779564 (-)



Homology
more
  • Human Ortholog
    BCAR1, BCAR1 scaffold protein, Cas family member
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCAR1, BCAR1 scaffold protein, Cas family member
  • Synonyms
    CAS, CAS1, CASS1, CRKAS, P130Cas
  • Links
    NCBI Gene ID: 9564
    neXtProt AC: NX_P56945
    UniProt: P56945

  • Chr Location
    16q23.1; chr16:75228181-75268053 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BCAR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos exhibit growth retardation and embryonic lethality, following disruption of cardiac myofibrils, increased vasodilation, and systemic congestion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    888
  • Tissues
    70
  • cDNA Data
    107
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031955 Ensembl Gene Model | MGI Sequence Detail 33336 C57BL/6J ±  kb
    transcript ENSMUST00000166232 Ensembl | MGI Sequence Detail 3142 Not Applicable  
    polypeptide ENSMUSP00000129584 Ensembl | MGI Sequence Detail 874 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 109
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37128, MGI:2142520
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 23
      Gene Ontology 18
      Phenotypes 21
    • Earliest
      J:20302 Shaffer JB, et al., Isolation of a cDNA clone for murine catalase and analysis of an acatalasemic mutant. J Biol Chem. 1987 Sep 25;262(27):12908-11
    • Latest
      J:339438 Wong W, et al., An adhesion signaling axis involving Dystroglycan, beta1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold. PLoS Biol. 2023 Aug;21(8):e3002212
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory