Zfp185 MGI Mouse Gene Detail - MGI:108095

Symbol

Zfp185
Name

zinc finger protein 185
Synonyms

P1-

Feature Type

protein coding gene
IDs

MGI:108095
NCBI Gene: 22673
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

ChrX:72030945-72075149 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 37.29 cM
Mapping Data

3 experiments

SNPs within 2kb

501 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108095	protein coding gene	ChrX:72030860-72075149 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035797	protein coding gene	ChrX:68683928-68728731 (+)
A/J	MGP_AJ_G0035781	protein coding gene	ChrX:68877720-68922611 (+)
AKR/J	MGP_AKRJ_G0035703	protein coding gene	ChrX:70722062-70766588 (+)
BALB/cJ	MGP_BALBcJ_G0035768	protein coding gene	ChrX:67898603-67943529 (+)
C3H/HeJ	MGP_C3HHeJ_G0035471	protein coding gene	ChrX:69178492-69225461 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036298	protein coding gene	ChrX:70762011-70808290 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033145	protein coding gene	ChrX:67999243-68042130 (+)
CAST/EiJ	MGP_CASTEiJ_G0034763	protein coding gene	ChrX:54493877-54538735 (+)
CBA/J	MGP_CBAJ_G0035446	protein coding gene	ChrX:72685821-72737096 (+)
DBA/2J	MGP_DBA2J_G0035599	protein coding gene	ChrX:68370548-68415571 (+)
FVB/NJ	MGP_FVBNJ_G0035550	protein coding gene	ChrX:67706797-67752103 (+)
LP/J	MGP_LPJ_G0035688	protein coding gene	ChrX:69536543-69580747 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035585	protein coding gene	ChrX:75313557-75360591 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036319	protein coding gene	ChrX:68528823-68573784 (+)
PWK/PhJ	MGP_PWKPhJ_G0034463	protein coding gene	ChrX:52492763-52538283 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034298	protein coding gene	ChrX:55441789-55487143 (+)
WSB/EiJ	MGP_WSBEiJ_G0034905	protein coding gene	ChrX:67826239-67870674 (+)

Human Ortholog

ZNF185, zinc finger protein 185 with LIM domain

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF185, zinc finger protein 185 with LIM domain
Synonyms

SCELL
Links

HGNC:12976

NCBI Gene ID: 7739

neXtProt AC: NX_O15231

UniProt: O15231
Chr Location

Xq28; chrX:152898067-152973481 (+) GRCh38

MGI Vertebrate Homology

Zfp185 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZNF185
Gene Tree

Zfp185

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Gene trapped

2
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a null allele display increased vascular permeability under inflammatory conditions.

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All GO Annotations

4
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

884
Tissues

72
cDNA Data

29
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN znf185

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All Sequences

56
RefSeq

10
UniProt

8
CCDS

CCDS30191.2, CCDS53091.1

Ensembl

ENSMUSG00000031351 (Evidence)
NCBI Gene

22673

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031351	Ensembl Gene Model \| MGI Sequence Detail	44205	C57BL/6J	± kb
transcript	ENSMUST00000164800	Ensembl \| MGI Sequence Detail	3557	Not Applicable
polypeptide	ENSMUSP00000126066	Ensembl \| MGI Sequence Detail	486	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000017735 zinc finger protein 185

(term hierarchy)
InterPro Domains

IPR052621 Cell Proliferation and Cornified Envelope Regulator

IPR001781 Zinc finger, LIM-type

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All nucleic 34

cDNA 29

Primer pair 5

Microarray probesets 5

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MGD-MRK-37132

Summaries

All 36

Developmental Gene Expression 10

Gene Ontology 2

Phenotypes 6
Earliest

J:33576 Levin ML, et al., A comparative transcription map of the murine bare patches (Bpa) and striated (Str) critical regions and human Xq28. Genome Res. 1996 Jun;6(6):465-77
Latest

J:345303 Suzuki S, et al., ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells. Commun Biol. 2023 Jan 11;6(1):29

TSS for Zfp185:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161192	ChrX:72030958-72030972 (+)	20 bp
Tssr161193	ChrX:72040854-72040861 (+)	9,913 bp
Tssr161194	ChrX:72040867-72040874 (+)	9,926 bp
Tssr161195	ChrX:72040885-72040892 (+)	9,944 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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