Prkg2 MGI Mouse Gene Detail - MGI:108173 - protein kinase, cGMP-dependent, type II

Symbol

Prkg2
Name

protein kinase, cGMP-dependent, type II
Synonyms

cGK-II, Prkgr2

Feature Type

protein coding gene
IDs

MGI:108173
NCBI Gene: 19092
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr5:99077632-99185042 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 48.35 cM
Mapping Data

3 experiments

SNPs within 2kb

3216 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108173	protein coding gene	Chr5:99077632-99185210 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029777	protein coding gene	Chr5:100306931-100416820 (-)
A/J	MGP_AJ_G0029743	protein coding gene	Chr5:96599524-96707231 (-)
AKR/J	MGP_AKRJ_G0029689	protein coding gene	Chr5:99796859-99906247 (-)
BALB/cJ	MGP_BALBcJ_G0029753	protein coding gene	Chr5:97613849-97722583 (-)
C3H/HeJ	MGP_C3HHeJ_G0029476	protein coding gene	Chr5:100126508-100235258 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030208	protein coding gene	Chr5:104526568-104641897 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027443	protein coding gene	Chr5:91884344-91993650 (-)
CAST/EiJ	MGP_CASTEiJ_G0028887	protein coding gene	Chr5:98756455-98871142 (-)
CBA/J	MGP_CBAJ_G0029446	protein coding gene	Chr5:108118427-108229773 (-)
DBA/2J	MGP_DBA2J_G0029590	protein coding gene	Chr5:96786713-96899225 (-)
FVB/NJ	MGP_FVBNJ_G0029549	protein coding gene	Chr5:95604335-95712501 (-)
LP/J	MGP_LPJ_G0029678	protein coding gene	Chr5:100917170-101029253 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029578	protein coding gene	Chr5:113241090-113360260 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030241	protein coding gene	Chr5:99237312-99357531 (-)
PWK/PhJ	MGP_PWKPhJ_G0028605	protein coding gene	Chr5:95220440-95329848 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028440	protein coding gene	Chr5:96935471-97057795 (-)
WSB/EiJ	MGP_WSBEiJ_G0028965	protein coding gene	Chr5:99576430-99688598 (-)

Human Ortholog

PRKG2, protein kinase cGMP-dependent 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRKG2, protein kinase cGMP-dependent 2
Synonyms

AMD4, cGK2, cGKII, PKG2, PRKGR2, SMDP
Links

HGNC:9416

NCBI Gene ID: 5593

neXtProt AC: NX_Q13237

UniProt: Q13237
Chr Location

4q21.21; chr4:81087370-81217836 (-) GRCh38

MGI Vertebrate Homology

Prkg2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRKG2
Protein SuperFamily

cGMP-dep_kinase
Gene Tree

Prkg2

Diseases

2 with human PRKG2 associations

				Human Disease	Mouse Models
				acromesomelic dysplasia-4 IDs acromesomelic dysplasia-4 DOID:0081238 OMIM:619636
				spondylometaphyseal dysplasia IDs spondylometaphyseal dysplasia DOID:0112295 ORDO:254

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

16 phenotypes from 1 allele in 1 genetic background
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Spontaneous

1
Targeted

4
Genomic Mutations

3 involving Prkg2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit dwarfism, with abnormal skull morphology and short limbs and vertebrae. Defects in axial organization of the growth plates was evident as mice aged. Digestive secretion in response to enterotoxin was reduced.

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All GO Annotations

26
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

10
cDNA Data

18
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prkg2

ZFIN prkg2

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All Sequences

55
RefSeq

8
UniProt

6
CCDS

CCDS19459.1

Ensembl

ENSMUSG00000029334 (Evidence)
NCBI Gene

19092

			Length	Strain/Species	Flank
genomic	19092	NCBI Gene Model \| MGI Sequence Detail	107411	C57BL/6J	± kb
transcript	NM_008926	RefSeq \| MGI Sequence Detail	4696	ZRU/MplStud
polypeptide	Q61410	UniProt \| EBI \| MGI Sequence Detail	762	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013240 cGMP-dependent protein kinase 2

(term hierarchy)
EC

2.7.11.12
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR002374 cGMP-dependent kinase

IPR035014 cGMP-dependent protein kinase, catalytic domain

IPR018488 Cyclic nucleotide-binding, conserved site

IPR000595 Cyclic nucleotide-binding domain

IPR018490 Cyclic nucleotide-binding domain superfamily

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR014710 RmlC-like jelly roll fold

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q61410 1 site, 1 N-linked glycan (1 site)

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All nucleic 22

Genomic 1

cDNA 18

Primer pair 3

Microarray probesets 7

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MGD-MRK-19671, MGD-MRK-37212, MGI:2141175

Summaries

All 72

Developmental Gene Expression 5

Gene Ontology 10

Phenotypes 27
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:347239 Kalyanaraman H, et al., Protein Kinase G2 Is Essential for Skeletal Homeostasis and Adaptation to Mechanical Loading in Male but Not Female Mice. J Bone Miner Res. 2023 Jan;38(1):171-185

TSS for Prkg2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr52023	Chr5:99185228-99185243 (-)	-194 bp
Tssr52022	Chr5:99185201-99185212 (-)	-165 bp
Tssr52021	Chr5:99185007-99185065 (-)	6 bp
Tssr52019	Chr5:99169454-99169457 (-)	15,586 bp
Tssr52018	Chr5:99114649-99114658 (-)	70,388 bp
Tssr1556	Chr5:99101956-99101957 (-)	83,085 bp
Tssr52017	Chr5:99091736-99091750 (-)	93,299 bp
Tssr52016	Chr5:99091681-99091699 (-)	93,352 bp
Tssr52015	Chr5:99091645-99091664 (-)	93,387 bp
Tssr52014	Chr5:99091622-99091632 (-)	93,415 bp
Tssr52013	Chr5:99084514-99084517 (-)	100,526 bp
Tssr52012	Chr5:99079568-99079572 (-)	105,472 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24