Ccl12 MGI Mouse Gene Detail - MGI:108224 - C-C motif chemokine ligand 12

Symbol

Ccl12
Name

C-C motif chemokine ligand 12
Synonyms

MCP-5, Scya12

Feature Type

protein coding gene
IDs

MGI:108224
NCBI Gene: 20293
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:81992671-81994225 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 49.90 cM
Mapping Data

6 experiments

SNPs within 2kb

157 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108224	protein coding gene	Chr11:81992671-81994226 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018824	protein coding gene	Chr11:83350697-83352252 (+)
A/J	MGP_AJ_G0018791	protein coding gene	Chr11:80144908-80146463 (+)
AKR/J	MGP_AKRJ_G0018761	protein coding gene	Chr11:82543483-82545038 (+)
BALB/cJ	MGP_BALBcJ_G0018764	protein coding gene	Chr11:80538146-80539701 (+)
C3H/HeJ	MGP_C3HHeJ_G0018578	protein coding gene	Chr11:82591559-82593114 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019216	protein coding gene	Chr11:85848941-85850496 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016850	protein coding gene	Chr11:77115545-77117108 (+)
CAST/EiJ	MGP_CASTEiJ_G0018133	protein coding gene	Chr11:83149999-83151555 (+)
CBA/J	MGP_CBAJ_G0018549	protein coding gene	Chr11:89617217-89618772 (+)
DBA/2J	MGP_DBA2J_G0018657	protein coding gene	Chr11:79707070-79708625 (+)
FVB/NJ	MGP_FVBNJ_G0018646	protein coding gene	Chr11:79253342-79254897 (+)
LP/J	MGP_LPJ_G0018727	protein coding gene	Chr11:83878094-83879649 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018673	protein coding gene	Chr11:89796565-89798120 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019256	protein coding gene	Chr11:82808239-82809794 (+)
PWK/PhJ	MGP_PWKPhJ_G0017903	protein coding gene	Chr11:80533742-80535298 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017694	protein coding gene	Chr11:82422673-82424232 (+)
WSB/EiJ	MGP_WSBEiJ_G0018185	protein coding gene	Chr11:82685458-82687014 (+)

Human Ortholog

CCL2, C-C motif chemokine ligand 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCL2, C-C motif chemokine ligand 2
Synonyms

GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF
Links

HGNC:10618

NCBI Gene ID: 6347

neXtProt AC: NX_P13500

UniProt: P13500
Chr Location

17q12; chr17:34255274-34257208 (+) GRCh38

MGI Vertebrate Homology

Ccl12 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CCL2
Gene Tree

Ccl12

Diseases

21 with human CCL13,CCL2 associations

				Human Disease	Mouse Models
				aggressive periodontitis IDs aggressive periodontitis DOID:1474 ICD10CM:K05.2 MESH:D010520 OMIM:170650 OMIM:608526 UMLS_CUI:C0031106
				anterior uveitis IDs anterior uveitis DOID:1407 MESH:D014606 NCI:C35109 UMLS_CUI:C0042165
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				Behcet's disease IDs Behcet's disease DOID:13241 EFO:0003780 ICD10CM:M35.2 ICD9CM:136.1 ICD9CM_2006:136.1 MESH:D001528 NCI:C34416 OMIM:109650 UMLS_CUI:C0004943
				bipolar disorder IDs bipolar disorder DOID:3312 DOID:3311 DOID:9554 DOID:9555 ICD10CM:F31 ICD9CM:296.40 ICD9CM:296.60 ICD9CM:296.80 MESH:D001714 NCI:C34423 NCI:C34424 NCI:C34805 UMLS_CUI:C0005586 UMLS_CUI:C0005587 UMLS_CUI:C0024713 UMLS_CUI:C0236780
				end stage renal disease IDs end stage renal disease DOID:783
				familial hyperlipidemia IDs familial hyperlipidemia DOID:1168 DOID:3147 ICD10CM:E78.5 MESH:D006949 MESH:D006951 NCI:C34707 NCI:C34709 UMLS_CUI:C0020473 UMLS_CUI:C0020476
				Henoch-Schoenlein purpura IDs Henoch-Schoenlein purpura DOID:11123 ICD10CM:D69.0 ICD9CM_2006:287.0 ICD9CM:287.0 MESH:D011695 NCI:C34963 UMLS_CUI:C0034152
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				ischemia IDs ischemia DOID:326 MESH:D007511 NCI:C34738 UMLS_CUI:C0022116
				lupus nephritis IDs lupus nephritis DOID:0080162 MESH:D008181
				multiple sclerosis IDs multiple sclerosis DOID:2377 ICD10CM:G35 ICD9CM:340 MESH:D009103 NCI:C3243 OMIM:612594 OMIM:612595 OMIM:612596 UMLS_CUI:C0026769
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				oral squamous cell carcinoma IDs oral squamous cell carcinoma DOID:0050866
				pancreatitis IDs pancreatitis DOID:4989 EFO:0000278 ICD10CM:K85.9 MESH:D010195 NCI:C3306 OMIM:167800 UMLS_CUI:C0030305
				proliferative diabetic retinopathy IDs proliferative diabetic retinopathy DOID:13207 ICD9CM:362.02 NCI:C84457 UMLS_CUI:C0154830
				pulmonary tuberculosis IDs pulmonary tuberculosis DOID:2957 ICD10CM:A15 ICD9CM:011 ICD9CM:011.9 ICD9CM:011.90 MESH:D014397 NCI:C26899 UMLS_CUI:C0041327
				skin melanoma IDs skin melanoma DOID:8923 DOID:0050609 DOID:10043 DOID:10046 DOID:10051 DOID:10052 DOID:10055 DOID:8922 ICD10CM:C43.9 ICD9CM:172 ICD9CM:172.0 ICD9CM:172.2 ICD9CM:172.4 ICD9CM:172.5 ICD9CM:172.9 MESH:C562393 NCI:C3510 OMIM:608035 OMIM:612263 UMLS_CUI:C0151779
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141
				temporal arteritis IDs temporal arteritis DOID:13375 ICD9CM:446.5 MESH:D013700 NCI:C35065 OMIM:187360 ORDO:397 UMLS_CUI:C0039483
				thrombocytopenia IDs thrombocytopenia DOID:1588 ICD10CM:D69.6 ICD9CM:287.5 MESH:D013921 OMIM:188000 OMIM:273900 OMIM:300367 OMIM:313900 OMIM:612004 ORDO:852 UMLS_CUI:C0040034

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 2 alleles in 1 genetic background
18 phenotype references

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

5
Genomic Mutations

2 involving Ccl12
Incidental Mutations

APF
Find Mice (IMSR)

16 strains or lines available

Mice homozygous for a knock-out allele are viable, fertile and developmentally normal with no apparent alterations in monocyte homeostasis.

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All GO Annotations

32
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

28
cDNA Data

19
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS36247.1

Ensembl

ENSMUSG00000035352 (Evidence)
NCBI Gene

20293

			Length	Strain/Species	Flank
genomic	20293	NCBI Gene Model \| MGI Sequence Detail	1555	C57BL/6J	± kb
transcript	NM_011331	RefSeq \| MGI Sequence Detail	536	ZRU/MplStud
polypeptide	Q62401	UniProt \| EBI \| MGI Sequence Detail	104	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006165 C-C motif chemokine 12

(term hierarchy)
InterPro Domains

IPR000827 CC chemokine, conserved site

IPR039809 Chemokine beta/gamma/delta

IPR001811 Chemokine interleukin-8-like domain

IPR036048 Chemokine interleukin-8-like superfamily

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All nucleic 23

Genomic 3

cDNA 19

Primer pair 1

Microarray probesets 3

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MGD-MRK-37263

Summaries

All 57

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 18
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:358349 Ross JL, et al., Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations. Immunity. 2024 Oct 8;

TSS for Ccl12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103568	Chr11:81992644-81992655 (+)	-21 bp
Tssr103569	Chr11:81992662-81992675 (+)	-2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24