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Enah Gene Detail
Summary
  • Symbol
    Enah
  • Name
    ENAH actin regulator
  • Synonyms
    Mena, Ndpp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108360
    NCBI Gene: 13800
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:181723949-181847555 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 84.93 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3215 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108360
 protein coding gene Chr1:181723949-181848132 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016889
 protein coding gene Chr1:188472349-188614442 (-)
A/J MGP_AJ_G0016868
 protein coding gene Chr1:180812160-180936224 (-)
AKR/J MGP_AKRJ_G0016834
 protein coding gene Chr1:186193252-186325044 (-)
BALB/cJ MGP_BALBcJ_G0016826
 protein coding gene Chr1:181448739-181578762 (-)
C3H/HeJ MGP_C3HHeJ_G0016651
 protein coding gene Chr1:186981271-187108476 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017289
 protein coding gene Chr1:194575586-194709020 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014996
 protein coding gene Chr1:171776154-171891079 (-)
CAST/EiJ MGP_CASTEiJ_G0016232
 protein coding gene Chr1:186342881-186475873 (-)
CBA/J MGP_CBAJ_G0016625
 protein coding gene Chr1:201778486-201933200 (-)
DBA/2J MGP_DBA2J_G0016731
 protein coding gene Chr1:179625442-179749886 (-)
FVB/NJ MGP_FVBNJ_G0016727
 protein coding gene Chr1:177737533-177865048 (-)
LP/J MGP_LPJ_G0016805
 protein coding gene Chr1:189689978-189820506 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016758
 protein coding gene Chr1:208851236-208992875 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017326
 protein coding gene Chr1:185993707-186126457 (-)
PWK/PhJ MGP_PWKPhJ_G0016020
 protein coding gene Chr1:178775514-178907576 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015796
 protein coding gene Chr1:184952321-185079493 (-)
WSB/EiJ MGP_WSBEiJ_G0016295
 protein coding gene Chr1:186191179-186328179 (-)



Homology
more
  • Human Ortholog
    ENAH, ENAH actin regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENAH, ENAH actin regulator
  • Synonyms
    ENA, MENA, NDPP1
  • Links
    NCBI Gene ID: 55740
    neXtProt AC: NX_Q8N8S7
    UniProt: Q8N8S7

  • Chr Location
    1q42.12; chr1:225486765-225653878 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    21 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation show defects in major axonal projection pathways in brain, including malformation of the hippocampal commissure and pontocerebellar fibers and frequent agenesis of the corpus callosum due to a failure of axons to project across the midline during development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    955
  • Tissues
    122
  • cDNA Data
    20
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022995 Ensembl Gene Model | MGI Sequence Detail 123607 C57BL/6J ±  kb
    transcript ENSMUST00000078719 Ensembl | MGI Sequence Detail 2889 Not Applicable  
    polypeptide ENSMUSP00000077781 Ensembl | MGI Sequence Detail 804 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 22
      Primer pair 6
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12800, MGD-MRK-37400, MGI:2138266, MGI:2138537, MGI:97291
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 25
      Gene Ontology 14
      Phenotypes 26
    • Earliest
      J:3109 Sazuka T, et al., Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein. Biochim Biophys Acta. 1992 Oct 20;1132(3):240-8
    • Latest
      J:320239 Borriello L, et al., Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells. Nat Commun. 2022 Feb 2;13(1):626
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory