Sephs2 MGI Mouse Gene Detail - MGI:108388 - selenophosphate synthetase 2

Symbol

Sephs2
Name

selenophosphate synthetase 2
Synonyms

Sps2, Ysg3

Feature Type

protein coding gene
IDs

MGI:108388
NCBI Gene: 20768
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:126871051-126873227 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.43 cM
Mapping Data

2 experiments

SNPs within 2kb

123 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108388	protein coding gene	Chr7:126871051-126873231 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033030	protein coding gene	Chr7:131613337-131615514 (-)
A/J	MGP_AJ_G0033013	protein coding gene	Chr7:128105813-128107988 (-)
AKR/J	MGP_AKRJ_G0032945	protein coding gene	Chr7:131359700-131361875 (-)
BALB/cJ	MGP_BALBcJ_G0033018	protein coding gene	Chr7:127772482-127774649 (-)
C3H/HeJ	MGP_C3HHeJ_G0032728	protein coding gene	Chr7:131297762-131299932 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033524	protein coding gene	Chr7:136723844-136726011 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030496	protein coding gene	Chr7:129315485-129317650 (-)
CAST/EiJ	MGP_CASTEiJ_G0032057	protein coding gene	Chr7:123090700-123092874 (-)
CBA/J	MGP_CBAJ_G0032701	protein coding gene	Chr7:141331561-141333776 (-)
DBA/2J	MGP_DBA2J_G0032853	protein coding gene	Chr7:126078529-126080696 (-)
FVB/NJ	MGP_FVBNJ_G0032806	protein coding gene	Chr7:125932476-125934646 (-)
LP/J	MGP_LPJ_G0032947	protein coding gene	Chr7:133072565-133074735 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032838	protein coding gene	Chr7:142467675-142469840 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033543	protein coding gene	Chr7:130377971-130380146 (-)
PWK/PhJ	MGP_PWKPhJ_G0031765	protein coding gene	Chr7:119088289-119090511 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031610	protein coding gene	Chr7:117215595-117217759 (-)
WSB/EiJ	MGP_WSBEiJ_G0032169	protein coding gene	Chr7:131345551-131347727 (-)

Human Ortholog

SEPHS2, selenophosphate synthetase 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SEPHS2, selenophosphate synthetase 2
Synonyms

SPS2
Links

HGNC:19686

NCBI Gene ID: 22928

neXtProt AC: NX_Q99611

UniProt: Q99611
Chr Location

16p11.2; chr16:30443631-30445874 (-) GRCh38

MGI Vertebrate Homology

Sephs2 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: SEPHS2
Gene Tree

Sephs2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

3
Gene trapped

1
Targeted

1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

19 strains or lines available

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All GO Annotations

9
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

926
Tissues

138
cDNA Data

15
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS21863.1

Ensembl

ENSMUSG00000049091 (Evidence)
NCBI Gene

20768

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049091	Ensembl Gene Model \| MGI Sequence Detail	2177	C57BL/6J	± kb
transcript	ENSMUST00000082428	Ensembl \| MGI Sequence Detail	2177	Not Applicable
polypeptide	ENSMUSP00000081009	Ensembl \| MGI Sequence Detail	452	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014644 selenide, water dikinase 2

(term hierarchy)
EC

2.7.9.3
InterPro Domains

IPR010918 PurM-like, C-terminal domain

IPR036676 PurM-like, C-terminal domain superfamily

IPR016188 PurM-like, N-terminal domain

IPR036921 PurM-like, N-terminal domain superfamily

IPR004536 Selenophosphate synthetase

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All nucleic 15

cDNA 15

Microarray probesets 5

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MGD-MRK-28095, MGD-MRK-37428

Summaries

All 33

Developmental Gene Expression 5

Gene Ontology 3

Phenotypes 8
Earliest

J:29278 Guimaraes MJ, et al., A new approach to the study of haematopoietic development in the yolk sac and embryoid bodies. Development. 1995 Oct;121(10):3335-46
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sephs2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr74986	Chr7:126873253-126873261 (-)	-30 bp
Tssr74985	Chr7:126873219-126873238 (-)	-2 bp
Tssr74984	Chr7:126873180-126873208 (-)	33 bp
Tssr2405	Chr7:126873163-126873172 (-)	59 bp
Tssr74983	Chr7:126872684-126872697 (-)	536 bp
Tssr74982	Chr7:126872302-126872332 (-)	910 bp
Tssr74981	Chr7:126871655-126871661 (-)	1,569 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24