Kif4 MGI Mouse Gene Detail - MGI:108389

Symbol

Kif4
Name

kinesin family member 4
Synonyms

D330050K22Rik, Kns4, N-5 kinesin

Feature Type

protein coding gene
IDs

MGI:108389
NCBI Gene: 16571
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

ChrX:99669693-99770878 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 43.72 cM
Mapping Data

4 experiments

SNPs within 2kb

2162 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108389	protein coding gene	ChrX:99669343-99770878 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035947	protein coding gene	ChrX:97085236-97189558 (+)
A/J	MGP_AJ_G0035932	protein coding gene	ChrX:97128879-97228660 (+)
AKR/J	MGP_AKRJ_G0035848	protein coding gene	ChrX:99914181-100014574 (+)
BALB/cJ	MGP_BALBcJ_G0035915	protein coding gene	ChrX:95873089-95973326 (+)
C3H/HeJ	MGP_C3HHeJ_G0035624	protein coding gene	ChrX:97517106-97620649 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036444	protein coding gene	ChrX:99997654-100104655 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033274	protein coding gene	ChrX:94902149-95004665 (+)
CAST/EiJ	MGP_CASTEiJ_G0034911	protein coding gene	ChrX:81820114-81924286 (+)
CBA/J	MGP_CBAJ_G0035599	protein coding gene	ChrX:103092132-103200985 (+)
DBA/2J	MGP_DBA2J_G0035753	protein coding gene	ChrX:96334723-96431884 (+)
FVB/NJ	MGP_FVBNJ_G0035691	protein coding gene	ChrX:95734297-95831925 (+)
LP/J	MGP_LPJ_G0035843	protein coding gene	ChrX:98067217-98169476 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035726	protein coding gene	ChrX:107622809-107728615 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036471	protein coding gene	ChrX:96802015-96907442 (+)
PWK/PhJ	MGP_PWKPhJ_G0034610	protein coding gene	ChrX:79440313-79542862 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034438	protein coding gene	ChrX:82707641-82809144 (+)
WSB/EiJ	MGP_WSBEiJ_G0035050	protein coding gene	ChrX:95518827-95621441 (+)

Human Ortholog

KIF4A, kinesin family member 4A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF4A, kinesin family member 4A
Synonyms

KIF4, KIF4G1, MRX100, TMDI, XLID100
Links

HGNC:13339

NCBI Gene ID: 24137

neXtProt AC: NX_O95239

UniProt: O95239
Chr Location

Xq13.1; chrX:70290104-70420886 (+) GRCh38

Human Ortholog

KIF4B, kinesin family member 4B
Links

HGNC:6322

NCBI Gene ID: 285643

neXtProt AC: NX_Q2VIQ3

UniProt: Q2VIQ3
Chr Location

5q33.2

MGI Vertebrate Homology

Kif4 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KIF4A, KIF4B
Gene Tree

Kif4

Diseases

1 with human KIF4A associations

				Human Disease	Mouse Models
				non-syndromic X-linked intellectual disability 100 IDs non-syndromic X-linked intellectual disability 100 DOID:0112040 OMIM:300923

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
10 images
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

3
Gene trapped

10
Targeted

2
Incidental Mutations

CvDC
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male chimeras hemizygous for a gene trapped allele appear normal at E9.5.

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

877
Tissues

115
cDNA Data

105
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KIF4B

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All Sequences

46
RefSeq

8
UniProt

3
CCDS

CCDS30305.1

Ensembl

ENSMUSG00000034311 (Evidence)
NCBI Gene

16571

			Length	Strain/Species	Flank
genomic	16571	NCBI Gene Model \| MGI Sequence Detail	101186	C57BL/6J	± kb
transcript	NM_008446	RefSeq \| MGI Sequence Detail	4691	ZRU/MplStud
polypeptide	P33174	UniProt \| EBI \| MGI Sequence Detail	1231	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009602 chromosome-associated kinesin KIF4

(term hierarchy)
PDB

3ZFC, 3ZFD
InterPro Domains

IPR027640 Kinesin-like protein

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR033467 Tesmin/TSO1-like CXC domain
GlyGen

P33174 1 site, 1 O-linked glycan (1 site)

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All nucleic 109

Genomic 1

cDNA 105

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-11593, MGD-MRK-37429, MGI:2147873

Summaries

All 52

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 8
Earliest

J:3448 Aizawa H, et al., Kinesin family in murine central nervous system. J Cell Biol. 1992 Dec;119(5):1287-96
Latest

J:336792 Wan Y, et al., KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway. J Cell Biol. 2023 Feb 6;222(2)

TSS for Kif4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161615	ChrX:99669678-99669764 (+)	28 bp
Tssr161616	ChrX:99700053-99700057 (+)	30,362 bp
Tssr161617	ChrX:99750447-99750448 (+)	80,755 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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