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Kif2a Gene Detail
Summary
  • Symbol
    Kif2a
  • Name
    kinesin family member 2A
  • Synonyms
    Kif2, Kns2, M-kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:108390
    NCBI Gene: 16563
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:107095504-107158634 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 58.06 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1456 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108390
 protein coding gene Chr13:107095504-107158931 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020918
 protein coding gene Chr13:109153231-109220636 (-)
A/J MGP_AJ_G0020869
 protein coding gene Chr13:104904391-104967926 (-)
AKR/J MGP_AKRJ_G0020844
 protein coding gene Chr13:108077372-108152738 (-)
BALB/cJ MGP_BALBcJ_G0020869
 protein coding gene Chr13:105603691-105670445 (-)
C3H/HeJ MGP_C3HHeJ_G0020658
 protein coding gene Chr13:107841577-107908648 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021303
 protein coding gene Chr13:112464710-112530179 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018873
 protein coding gene Chr13:100336180-100401840 (-)
CAST/EiJ MGP_CASTEiJ_G0020177
 protein coding gene Chr13:107338120-107414058 (-)
CBA/J MGP_CBAJ_G0020620
 protein coding gene Chr13:116784563-116853387 (-)
DBA/2J MGP_DBA2J_G0020744
 protein coding gene Chr13:104663883-104727715 (-)
FVB/NJ MGP_FVBNJ_G0020726
 protein coding gene Chr13:103321637-103386254 (-)
LP/J MGP_LPJ_G0020818
 protein coding gene Chr13:109235917-109299283 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020754
 protein coding gene Chr13:117253503-117333421 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021342
 protein coding gene Chr13:107504450-107569692 (-)
PWK/PhJ MGP_PWKPhJ_G0019930
 protein coding gene Chr13:103321366-103386458 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019752
 protein coding gene Chr13:103764921-103829481 (-)
WSB/EiJ MGP_WSBEiJ_G0020235
 protein coding gene Chr13:108059678-108126472 (-)



Homology
more
  • Human Ortholog
    KIF2A, kinesin family member 2A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF2A, kinesin family member 2A
  • Synonyms
    CDCBM3, HK2, KIF2
  • Links
    NCBI Gene ID: 3796
    neXtProt AC: NX_O00139
    UniProt: O00139

  • Chr Location
    5q12.1; chr5:62306162-62391025 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KIF2A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality, abnormal lamination of the cerebral cortex, hippocampus and cerebellum, impaired neuronal migration, and abnormal axon outgrowth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    20
  • cDNA Data
    106
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021693 Ensembl Gene Model | MGI Sequence Detail 63131 C57BL/6J ±  kb
    transcript ENSMUST00000159772 Ensembl | MGI Sequence Detail 2570 Not Applicable  
    polypeptide ENSMUSP00000125644 Ensembl | MGI Sequence Detail 743 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000009308 kinesin-like protein KIF2A
      (term hierarchy)
    • InterPro Domains
      IPR027640 Kinesin-like protein
      IPR001752 Kinesin motor domain
      IPR019821 Kinesin motor domain, conserved site
      IPR036961 Kinesin motor domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      P28740 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 112
      cDNA 106
      Primer pair 5
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11591, MGD-MRK-37430
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 11
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:3448 Aizawa H, et al., Kinesin family in murine central nervous system. J Cell Biol. 1992 Dec;119(5):1287-96
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory