About   Help   FAQ
Tcf20 Gene Detail
Summary
  • Symbol
    Tcf20
  • Name
    transcription factor 20
  • Synonyms
    2810438H08Rik, mKIAA0292, SPBP, stromelysin 1 PDGF responsive element binding protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:108399
    NCBI Gene: 21411
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:82692637-82872073 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 38.73 cM, cytoband E
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2888 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108399
 protein coding gene Chr15:82692637-82872304 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022155
 protein coding gene Chr15:83438529-83553880 (-)
A/J MGP_AJ_G0022114
 protein coding gene Chr15:80405354-80511673 (-)
AKR/J MGP_AKRJ_G0022089
 protein coding gene Chr15:82714495-82825766 (-)
BALB/cJ MGP_BALBcJ_G0022120
 protein coding gene Chr15:80544218-80650716 (-)
C3H/HeJ MGP_C3HHeJ_G0021890
 protein coding gene Chr15:82709223-82822230 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022565
 protein coding gene Chr15:86668134-86778341 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020089
 protein coding gene Chr15:76810586-76911534 (-)
CAST/EiJ MGP_CASTEiJ_G0021412
 protein coding gene Chr15:83435589-83548289 (-)
CBA/J MGP_CBAJ_G0021857
 protein coding gene Chr15:89407186-89526250 (-)
DBA/2J MGP_DBA2J_G0021984
 protein coding gene Chr15:79908559-80014669 (-)
FVB/NJ MGP_FVBNJ_G0021963
 protein coding gene Chr15:78940463-79044247 (-)
LP/J MGP_LPJ_G0022055
 protein coding gene Chr15:83603614-83716853 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021983
 protein coding gene Chr15:94342550-94463211 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022580
 protein coding gene Chr15:82736859-82852418 (-)
PWK/PhJ MGP_PWKPhJ_G0021153
 protein coding gene Chr15:79878661-79984048 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020987
 protein coding gene Chr15:82470483-82571148 (-)
WSB/EiJ MGP_WSBEiJ_G0021461
 protein coding gene Chr15:83249668-83356629 (-)



Homology
more
  • Human Ortholog
    TCF20, transcription factor 20
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCF20, transcription factor 20
  • Synonyms
    AR1, DDVIBA, SPBP, TCF-20
  • Links
    NCBI Gene ID: 6942
    neXtProt AC: NX_Q9UGU0
    UniProt: Q9UGU0

  • Chr Location
    22q13.3; chr22:42160013-42343616 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Tcf20 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit 80% lethality by P14, growth retardation, impaired neurogenesis, and decreased vocalization. Heterozygous mice show repetitive behaviors, social interaction defects, impaired working memory, and increased anxiety and vocalization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    81
  • cDNA Data
    7
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041852 Ensembl Gene Model | MGI Sequence Detail 179437 C57BL/6J ±  kb
    transcript ENSMUST00000109510 Ensembl | MGI Sequence Detail 7323 Not Applicable  
    polypeptide ENSMUSP00000105136 Ensembl | MGI Sequence Detail 1987 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000003431 transcription factor 20
      (term hierarchy)
    • InterPro Domains
      IPR034732 Extended PHD (ePHD) domain
      IPR052440 Transcriptional Regulator and Chromatin Remodeler
      IPR041972 Transcription factor 20, ePHD domain
      IPR001965 Zinc finger, PHD-type
      IPR013083 Zinc finger, RING/FYVE/PHD-type
    • GlyGen
      Q9EPQ8 6 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 8
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37441, MGI:1924331
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 10
      Diseases 2
      Gene Ontology 6
      Phenotypes 34
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory