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Polr1d Gene Detail
Summary
  • Symbol
    Polr1d
  • Name
    polymerase (RNA) I polypeptide D
  • Synonyms
    1110003G10Rik, 16kDa, mRPA16, Rpo1-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:108403
    NCBI Gene: 20018
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:147013860-147048407 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 86.73 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1129 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108403
 protein coding gene Chr5:147013525-147048407 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030384
 protein coding gene Chr5:152706217-152743016 (+)
A/J MGP_AJ_G0030357
 protein coding gene Chr5:146242932-146277573 (+)
AKR/J MGP_AKRJ_G0030284
 protein coding gene Chr5:150728641-150764366 (+)
BALB/cJ MGP_BALBcJ_G0030366
 protein coding gene Chr5:147454201-147489254 (+)
C3H/HeJ MGP_C3HHeJ_G0030080
 protein coding gene Chr5:151696944-151731619 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030821
 protein coding gene Chr5:158291905-158327776 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028034
 protein coding gene Chr5:140656076-140690546 (+)
CAST/EiJ MGP_CASTEiJ_G0029482
 protein coding gene Chr5:151250115-151285367 (+)
CBA/J MGP_CBAJ_G0030058
 protein coding gene Chr5:164876860-164916536 (+)
DBA/2J MGP_DBA2J_G0030202
 protein coding gene Chr5:145923350-145957896 (+)
FVB/NJ MGP_FVBNJ_G0030156
 protein coding gene Chr5:145120717-145154602 (+)
LP/J MGP_LPJ_G0030289
 protein coding gene Chr5:153396573-153431877 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030192
 protein coding gene Chr5:167186098-167220478 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030851
 protein coding gene Chr5:150636242-150670847 (+)
PWK/PhJ MGP_PWKPhJ_G0029196
 protein coding gene Chr5:145004473-145039814 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029032
 protein coding gene Chr5:147959931-147994964 (+)
WSB/EiJ MGP_WSBEiJ_G0029559
 protein coding gene Chr5:151422583-151458679 (+)



Homology
more
  • Human Ortholog
    POLR1D, RNA polymerase I and III subunit D
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLR1D, RNA polymerase I and III subunit D
  • Synonyms
    AC19, POLR1C, RPA16, RPA9, RPAC2, RPC16, RPO1-3, TCS2
  • Links
    NCBI Gene ID: 51082
    neXtProt AC: NX_P0DPB5, NX_P0DPB6
    UniProt: P0DPB5, P0DPB6

  • Chr Location
    13q12.2; chr13:27620742-27744237 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human POLR1D associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality before implantation associated with embryonic growth retardation, impaired trophectoderm specification, failure of blastocyst formation, and increased cell death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    912
  • Tissues
    128
  • cDNA Data
    20
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029642 Ensembl Gene Model | MGI Sequence Detail 34548 C57BL/6J ±  kb
    transcript ENSMUST00000050970 Ensembl | MGI Sequence Detail 1196 Not Applicable  
    polypeptide ENSMUSP00000058355 Ensembl | MGI Sequence Detail 133 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000012985 POLR1D gene translation product
      (term hierarchy)
    • InterPro Domains
      IPR009025 DNA-directed RNA polymerase, RBP11-like dimerisation domain
      IPR008193 DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site
      IPR033898 DNA-directed RNA polymerases I and III subunit AC19
      IPR022905 DNA-directed RNA polymerase subunit Rpo11-like
      IPR038948 Protein POLR1D, isoform 2-like
      IPR036603 RNA polymerase, RBP11-like subunit
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 20
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-37446, MGI:2141038, MGI:2141323, MGI:2447827
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:37296 Yao Y, et al., Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III. J Biol Chem. 1996 Dec 20;271(51):32881-5
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory