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Apbb2 Gene Detail
Summary
  • Symbol
    Apbb2
  • Name
    amyloid beta precursor protein binding family B member 2
  • Synonyms
    2310007D03Rik, FE65L1, Rirl1, TR2L, Zfra
  • Feature Type
    protein coding gene
  • IDs
    MGI:108405
    NCBI Gene: 11787
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:66456046-66776127 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 34.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    9239 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108405
 protein coding gene Chr5:66456046-66779189 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029589
 protein coding gene Chr5:66027300-66359935 (-)
A/J MGP_AJ_G0029557
 protein coding gene Chr5:63548073-63865736 (-)
AKR/J MGP_AKRJ_G0029505
 protein coding gene Chr5:65593658-65916295 (-)
BALB/cJ MGP_BALBcJ_G0029566
 protein coding gene Chr5:64238629-64562146 (-)
C3H/HeJ MGP_C3HHeJ_G0029289
 protein coding gene Chr5:65912476-66236247 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030020
 protein coding gene Chr5:68766856-69101310 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027260
 protein coding gene Chr5:59613154-59939868 (-)
CAST/EiJ MGP_CASTEiJ_G0028697
 protein coding gene Chr5:65069025-65415437 (-)
CBA/J MGP_CBAJ_G0029258
 protein coding gene Chr5:70976334-71322754 (-)
DBA/2J MGP_DBA2J_G0029404
 protein coding gene Chr5:63573455-63890026 (-)
FVB/NJ MGP_FVBNJ_G0029364
 protein coding gene Chr5:62755011-63076741 (-)
LP/J MGP_LPJ_G0029489
 protein coding gene Chr5:66518544-66852078 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029392
 protein coding gene Chr5:73805991-74139513 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030053
 protein coding gene Chr5:65246364-65584174 (-)
PWK/PhJ MGP_PWKPhJ_G0028421
 protein coding gene Chr5:62580698-62910985 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028255
 protein coding gene Chr5:64609208-64934117 (-)
WSB/EiJ MGP_WSBEiJ_G0028777
 protein coding gene Chr5:65475308-65809799 (-)



Homology
more
  • Human Ortholog
    APBB2, amyloid beta precursor protein binding family B member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APBB2, amyloid beta precursor protein binding family B member 2
  • Synonyms
    FE65L, FE65L1
  • Links
    NCBI Gene ID: 323
    neXtProt AC: NX_Q92870
    UniProt: Q92870

  • Chr Location
    4p14-p13; chr4:40810027-41216714 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human APBB2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 4 alleles in 4 genetic backgrounds
    13 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile and display normal brain morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    856
  • Tissues
    59
  • cDNA Data
    85
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029207 Ensembl Gene Model | MGI Sequence Detail 320082 C57BL/6J ±  kb
    transcript ENSMUST00000162349 Ensembl | MGI Sequence Detail 3362 Not Applicable  
    polypeptide ENSMUSP00000123752 Ensembl | MGI Sequence Detail 760 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 87
      cDNA 86
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37448, MGI:1916734, MGI:3526137
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 35
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory