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Pde1c Gene Detail
Summary
  • Symbol
    Pde1c
  • Name
    phosphodiesterase 1C
  • Feature Type
    protein coding gene
  • IDs
    MGI:108413
    NCBI Gene: 18575
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:56046789-56629472 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 27.65 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16582 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108413
 protein coding gene Chr6:56046783-56629590 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030778
 protein coding gene Chr6:55517778-56017872 (-)
A/J MGP_AJ_G0030747
 protein coding gene Chr6:52930160-53416821 (-)
AKR/J MGP_AKRJ_G0030674
 protein coding gene Chr6:54718480-55205659 (-)
BALB/cJ MGP_BALBcJ_G0030759
 protein coding gene Chr6:53312765-53804511 (-)
C3H/HeJ MGP_C3HHeJ_G0030472
 protein coding gene Chr6:54753914-55256679 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031214
 protein coding gene Chr6:56762791-57282835 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028420
 protein coding gene Chr6:50535757-50988322 (-)
CAST/EiJ MGP_CASTEiJ_G0029875
 protein coding gene Chr6:54636769-55103301 (-)
CBA/J MGP_CBAJ_G0030446
 protein coding gene Chr6:59070690-59606703 (-)
DBA/2J MGP_DBA2J_G0030596
 protein coding gene Chr6:52827803-53307274 (-)
FVB/NJ MGP_FVBNJ_G0030548
 protein coding gene Chr6:52422101-52899442 (-)
LP/J MGP_LPJ_G0030681
 protein coding gene Chr6:55441568-55945105 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030582
 protein coding gene Chr6:61558894-62090954 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031244
 protein coding gene Chr6:54711038-55188599 (-)
PWK/PhJ MGP_PWKPhJ_G0029588
 protein coding gene Chr6:52505915-52978535 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029422
 protein coding gene Chr6:54071775-54570526 (-)
WSB/EiJ MGP_WSBEiJ_G0029952
 protein coding gene Chr6:54744590-55230259 (-)



Homology
more
  • Human Ortholog
    PDE1C, phosphodiesterase 1C
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE1C, phosphodiesterase 1C
  • Synonyms
    cam-PDE 1C, DFNA74, hCam-3, Hcam3
  • Links
    NCBI Gene ID: 5137
    neXtProt AC: NX_Q14123
    UniProt: Q14123

  • Chr Location
    7p14.3; chr7:31616777-32428224 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PDE1C associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Olfactory sensory nerves from homozygous null mice have significantly reduced action potentials in response to odor with slower onset kinetics and a faster response termination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1004
  • Tissues
    171
  • cDNA Data
    42
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004347 Ensembl Gene Model | MGI Sequence Detail 582684 C57BL/6J ±  kb
    transcript ENSMUST00000239143 Ensembl | MGI Sequence Detail 3174 Not Applicable  
    polypeptide ENSMUSP00000158960 Ensembl | MGI Sequence Detail 861 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000012468 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
      (term hierarchy)
    • EC
      3.1.4.-, 3.1.4.17
    • InterPro Domains
      IPR023088 3'5'-cyclic nucleotide phosphodiesterase
      IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
      IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
      IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
      IPR013706 3'5'-cyclic nucleotide phosphodiesterase N-terminal
      IPR003607 HD/PDEase domain
    • GlyGen
      Q64338 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 43
      Primer pair 4
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-37456
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 13
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:37553 Yan C, et al., Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9677-81
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory