Amot MGI Mouse Gene Detail - MGI:108440

Symbol

Amot
Name

angiomotin
Synonyms

D0Kist1, E230009N18Rik, mKIAA1071, Sii6

Feature Type

protein coding gene
IDs

MGI:108440
NCBI Gene: 27494
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

ChrX:144229420-144288145 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 66.72 cM
Mapping Data

3 experiments

SNPs within 2kb

1135 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108440	protein coding gene	ChrX:144229420-144288177 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0036162	protein coding gene	ChrX:143003355-143062571 (-)
A/J	MGP_AJ_G0036139	protein coding gene	ChrX:142332603-142392664 (-)
AKR/J	MGP_AKRJ_G0036065	protein coding gene	ChrX:146970129-147035637 (-)
BALB/cJ	MGP_BALBcJ_G0036130	protein coding gene	ChrX:140542701-140601359 (-)
C3H/HeJ	MGP_C3HHeJ_G0035838	protein coding gene	ChrX:143129274-143189875 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036654	protein coding gene	ChrX:147044752-147105345 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033477	protein coding gene	ChrX:133820225-133878612 (-)
CAST/EiJ	MGP_CASTEiJ_G0035129	protein coding gene	ChrX:123709067-123771028 (-)
CBA/J	MGP_CBAJ_G0035815	protein coding gene	ChrX:151571528-151633760 (-)
DBA/2J	MGP_DBA2J_G0035973	protein coding gene	ChrX:141391665-141450273 (-)
FVB/NJ	MGP_FVBNJ_G0035907	protein coding gene	ChrX:140604361-140664063 (-)
LP/J	MGP_LPJ_G0036064	protein coding gene	ChrX:143953345-144013106 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035943	protein coding gene	ChrX:159451339-159513573 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036690	protein coding gene	ChrX:142299242-142358185 (-)
PWK/PhJ	MGP_PWKPhJ_G0034823	protein coding gene	ChrX:120459391-120518937 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034649	protein coding gene	ChrX:124265707-124326016 (-)
WSB/EiJ	MGP_WSBEiJ_G0035264	protein coding gene	ChrX:140646991-140705690 (-)

Human Ortholog

AMOT, angiomotin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AMOT, angiomotin
Links

HGNC:17810

NCBI Gene ID: 154796

neXtProt AC: NX_Q4VCS5

UniProt: Q4VCS5
Chr Location

Xq23; chrX:112774503-112840831 (-) GRCh38

MGI Vertebrate Homology

Amot stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AMOT
Gene Tree

Amot

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Phenotype Summary

14 phenotypes from 1 allele in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

CvDC
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null mutation exhibit impaired migration into proximal extraembryonic regions resulting in furrows of visceral endoderm at the junction of embryonic and extraembryonic regions, vascular insufficiency in the intersomitic region, dilated vessels in the brain and embryonic lethality.

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All GO Annotations

66
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

9
cDNA Data

77
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AMOT

Xenbase amot

ZFIN amot

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All Sequences

62
RefSeq

14
UniProt

5
CCDS

CCDS72443.1

Ensembl

ENSMUSG00000041688 (Evidence)
NCBI Gene

27494

			Length	Strain/Species	Flank
genomic	27494	NCBI Gene Model \| MGI Sequence Detail	58726	C57BL/6J	± kb
transcript	NM_001403388	RefSeq \| MGI Sequence Detail	7827	C57BL/6
polypeptide	Q8VHG2	UniProt \| EBI \| MGI Sequence Detail	1126	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000003998 angiomotin

(term hierarchy)
InterPro Domains

IPR009114 Angiomotin

IPR024646 Angiomotin, C-terminal

IPR051747 Angiomotin-like regulatory protein
GlyGen

Q8VHG2 11 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (9 sites)

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All nucleic 79

cDNA 77

Primer pair 1

Other 1

Microarray probesets 5

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MGD-MRK-37484, MGI:2148071, MGI:2180948, MGI:2442022

Summaries

All 56

Developmental Gene Expression 11

Gene Ontology 11

Phenotypes 6
Earliest

J:44212 Kim SJ, et al., Cloning of novel trinucleotide-repeat (CAG) containing genes in mouse brain. Biochem Biophys Res Commun. 1997 Nov 7;240(1):239-43
Latest

J:336153 Skory RM, et al., The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization. Nat Commun. 2023 May 29;14(1):3101

TSS for Amot:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5698	ChrX:144288226-144288228 (-)	-82 bp
Tssr164344	ChrX:144288171-144288208 (-)	-45 bp
Tssr164343	ChrX:144288161-144288168 (-)	-20 bp
Tssr164342	ChrX:144288132-144288155 (-)	1 bp
Tssr164341	ChrX:144263672-144263677 (-)	24,470 bp
Tssr164340	ChrX:144263660-144263669 (-)	24,480 bp
Tssr164339	ChrX:144263638-144263653 (-)	24,499 bp
Tssr164338	ChrX:144263612-144263621 (-)	24,528 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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