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St6gal1 Gene Detail
Summary
  • Symbol
    St6gal1
  • Name
    beta galactoside alpha 2,6 sialyltransferase 1
  • Synonyms
    Siat1, St6Gal-I, ST6Gal I
  • Feature Type
    protein coding gene
  • IDs
    MGI:108470
    NCBI Gene: 20440
  • Alliance
    gene page
  • Transcription Start Sites
    47 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:23043490-23179100 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 14.03 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4115 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108470
 protein coding gene Chr16:23043478-23179100 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022682
 protein coding gene Chr16:20798074-20942133 (+)
A/J MGP_AJ_G0022644
 protein coding gene Chr16:19797426-19935655 (+)
AKR/J MGP_AKRJ_G0022618
 protein coding gene Chr16:20644116-20787911 (+)
BALB/cJ MGP_BALBcJ_G0022649
 protein coding gene Chr16:19999417-20135485 (+)
C3H/HeJ MGP_C3HHeJ_G0022413
 protein coding gene Chr16:20761127-20903989 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023098
 protein coding gene Chr16:21307293-21476995 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020616
 protein coding gene Chr16:20435050-20574996 (+)
CAST/EiJ MGP_CASTEiJ_G0021942
 protein coding gene Chr16:20739874-20891747 (+)
CBA/J MGP_CBAJ_G0022384
 protein coding gene Chr16:22161978-22321533 (+)
DBA/2J MGP_DBA2J_G0022516
 protein coding gene Chr16:19754697-19895388 (+)
FVB/NJ MGP_FVBNJ_G0022492
 protein coding gene Chr16:19752176-19894052 (+)
LP/J MGP_LPJ_G0022584
 protein coding gene Chr16:20589161-20728037 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022511
 protein coding gene Chr16:21696007-21845109 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023110
 protein coding gene Chr16:20594787-20737035 (+)
PWK/PhJ MGP_PWKPhJ_G0021681
 protein coding gene Chr16:20027566-20165905 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021512
 protein coding gene Chr16:20323619-20461888 (+)
WSB/EiJ MGP_WSBEiJ_G0021986
 protein coding gene Chr16:20545010-20693548 (+)



Homology
more
  • Human Ortholog
    ST6GAL1, ST6 beta-galactoside alpha-2,6-sialyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST6GAL1, ST6 beta-galactoside alpha-2,6-sialyltransferase 1
  • Synonyms
    CDw75, SIAT1, ST6GalI, ST6N
  • Links
    NCBI Gene ID: 6480
    neXtProt AC: NX_P15907
    UniProt: P15907

  • Chr Location
    3q27.3; chr3:186930325-187078553 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 4 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in altered terminal glycosylation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    116
  • cDNA Data
    16
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022885 Ensembl Gene Model | MGI Sequence Detail 135611 C57BL/6J ±  kb
transcript ENSMUST00000023601 Ensembl | MGI Sequence Detail 4506 Not Applicable  
polypeptide ENSMUSP00000023601 Ensembl | MGI Sequence Detail 403 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 2
    cDNA 16
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-37514, MGI:2146670
References
more
  • Summaries
    All 83
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 39
  • Earliest
    J:43576 Hamamoto T, et al., Two step single primer mediated polymerase chain reaction. Application to cloning of putative mouse, beta-galactoside alpha 2,6-sialyltransferase cDNA. Bioorg Med Chem. 1993 Aug;1(2):141-5
  • Latest
    J:345704 Ortigoza MB, et al., Inhibiting influenza virus transmission using a broadly acting neuraminidase that targets host sialic acids in the upper respiratory tract. mBio. 2024 Feb 14;15(2):e0220323
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory