Fzd6 MGI Mouse Gene Detail - MGI:108474 - frizzled class receptor 6

Symbol

Fzd6
Name

frizzled class receptor 6
Synonyms

Fz6

Feature Type

protein coding gene
IDs

MGI:108474
NCBI Gene: 14368
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:38869673-38901587 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15,
Mapping Data

5 experiments

SNPs within 2kb

501 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108474	protein coding gene	Chr15:38869429-38901587 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021811	protein coding gene	Chr15:37423120-37454167 (+)
A/J	MGP_AJ_G0021771	protein coding gene	Chr15:35965617-36004522 (+)
AKR/J	MGP_AKRJ_G0021752	protein coding gene	Chr15:37045083-37076829 (+)
BALB/cJ	MGP_BALBcJ_G0021778	protein coding gene	Chr15:36010905-36042714 (+)
C3H/HeJ	MGP_C3HHeJ_G0021552	protein coding gene	Chr15:36979850-37012374 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022217	protein coding gene	Chr15:38854831-38886572 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019754	protein coding gene	Chr15:33729366-33761650 (+)
CAST/EiJ	MGP_CASTEiJ_G0021069	protein coding gene	Chr15:37417511-37448664 (+)
CBA/J	MGP_CBAJ_G0021521	protein coding gene	Chr15:40201788-40236159 (+)
DBA/2J	MGP_DBA2J_G0021645	protein coding gene	Chr15:35800479-35832539 (+)
FVB/NJ	MGP_FVBNJ_G0021623	protein coding gene	Chr15:35211703-35243741 (+)
LP/J	MGP_LPJ_G0021715	protein coding gene	Chr15:37291297-37322494 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021647	protein coding gene	Chr15:43079312-43112290 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022240	protein coding gene	Chr15:37178002-37209854 (+)
PWK/PhJ	MGP_PWKPhJ_G0020814	protein coding gene	Chr15:35865232-35897235 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020651	protein coding gene	Chr15:36868284-36901378 (+)
WSB/EiJ	MGP_WSBEiJ_G0021124	protein coding gene	Chr15:37121295-37153933 (+)

Human Ortholog

FZD6, frizzled class receptor 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FZD6, frizzled class receptor 6
Synonyms

FZ-6, FZ6, HFZ6, NDNC1, NDNC10
Links

HGNC:4044

NCBI Gene ID: 8323

neXtProt AC: NX_O60353

UniProt: O60353
Chr Location

8q22.3; chr8:103298433-103332866 (+) GRCh38

MGI Vertebrate Homology

Fzd6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FZD6
Gene Tree

Fzd6

Diseases

1 with human FZD6 associations

				Human Disease	Mouse Models
				nonsyndromic congenital nail disorder 1 IDs nonsyndromic congenital nail disorder 1 DOID:0080079 OMIM:161050 ORDO:280654 ORDO:79153

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 3 alleles in 5 genetic backgrounds
14 phenotypes from multigenic genotypes
47 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

2
Endonuclease-mediated

5
Spontaneous

1
Targeted

9
Genomic Mutations

2 involving Fzd6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice display abnormal hair follicle orientation and hair growth pattern. Homozygosity for the p.S354I mutation leads to misorientation of just posterior hair follicles.

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All GO Annotations

37
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1344
Tissues

366
cDNA Data

15
Literature Summary

97

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fzd6

ZFIN fzd6

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All Sequences

61
RefSeq

16
UniProt

6
CCDS

CCDS27441.1

Ensembl

ENSMUSG00000022297 (Evidence)
NCBI Gene

14368

			Length	Strain/Species	Flank
genomic	14368	NCBI Gene Model \| MGI Sequence Detail	31915	C57BL/6J	± kb
transcript	NM_001411226	RefSeq \| MGI Sequence Detail	4301	C57BL/6
polypeptide	Q61089	UniProt \| EBI \| MGI Sequence Detail	709	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007722 frizzled-6

(term hierarchy)
InterPro Domains

IPR026543 Frizzled-6, 7TM

IPR041770 Frizzled 6, cysteine-rich domain

IPR036790 Frizzled cysteine-rich domain superfamily

IPR020067 Frizzled domain

IPR015526 Frizzled/secreted frizzled-related protein

IPR000539 Frizzled/Smoothened, 7TM

IPR017981 GPCR, family 2-like, 7TM
GlyGen

Q61089 3 sites

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All nucleic 39

Genomic 1

cDNA 16

Primer pair 17

Other 5

Microarray probesets 6

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MGD-MRK-14244, MGD-MRK-37518, MGI:98201

Summaries

All 167

Developmental Gene Expression 97

Gene Ontology 17

Phenotypes 47
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:355261 Rehmani T, et al., SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP. Life Sci Alliance. 2024 Dec;7(12)

TSS for Fzd6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131131	Chr15:38869415-38869443 (+)	-244 bp
Tssr131132	Chr15:38869486-38869501 (+)	-179 bp
Tssr131133	Chr15:38869667-38869760 (+)	41 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24