Nbr1 MGI Mouse Gene Detail - MGI:108498 - NBR1, autophagy cargo receptor

Symbol

Nbr1
Name

NBR1, autophagy cargo receptor
Synonyms

mKIAA0049

Feature Type

protein coding gene
IDs

MGI:108498
NCBI Gene: 17966
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:101442975-101472777 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 65.36 cM
Mapping Data

4 experiments

SNPs within 2kb

789 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108498	protein coding gene	Chr11:101442933-101472777 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019207	protein coding gene	Chr11:104434437-104466518 (+)
A/J	MGP_AJ_G0019175	protein coding gene	Chr11:100036752-100066922 (+)
AKR/J	MGP_AKRJ_G0019144	protein coding gene	Chr11:103144792-103176101 (+)
BALB/cJ	MGP_BALBcJ_G0019149	protein coding gene	Chr11:100528016-100557833 (+)
C3H/HeJ	MGP_C3HHeJ_G0018958	protein coding gene	Chr11:103321289-103351823 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019598	protein coding gene	Chr11:107702513-107738271 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017224	protein coding gene	Chr11:97429702-97460494 (+)
CAST/EiJ	MGP_CASTEiJ_G0018512	protein coding gene	Chr11:104301646-104330616 (+)
CBA/J	MGP_CBAJ_G0018927	protein coding gene	Chr11:112136525-112167864 (+)
DBA/2J	MGP_DBA2J_G0019039	protein coding gene	Chr11:99557579-99587241 (+)
FVB/NJ	MGP_FVBNJ_G0019029	protein coding gene	Chr11:99098765-99129507 (+)
LP/J	MGP_LPJ_G0019108	protein coding gene	Chr11:104964771-104995040 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019060	protein coding gene	Chr11:111699980-111732913 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019636	protein coding gene	Chr11:103480130-103511341 (+)
PWK/PhJ	MGP_PWKPhJ_G0018275	protein coding gene	Chr11:100620783-100650694 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018067	protein coding gene	Chr11:103211242-103240992 (+)
WSB/EiJ	MGP_WSBEiJ_G0018561	protein coding gene	Chr11:103468970-103501890 (+)

Human Ortholog

NBR1, NBR1 autophagy cargo receptor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NBR1, NBR1 autophagy cargo receptor
Synonyms

1A1-3B, IAI3B, M17S2, MIG19
Links

HGNC:6746

NCBI Gene ID: 4077

neXtProt AC: NX_Q14596

UniProt: Q14596
Chr Location

17q21.31; chr17:43170409-43211689 (+) GRCh38

MGI Vertebrate Homology

Nbr1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NBR1
Gene Tree

Nbr1

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Phenotype Summary

21 phenotypes from 3 alleles in 3 genetic backgrounds
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Endonuclease-mediated

3
Gene trapped

24
Targeted

9
Genomic Mutations

1 involving Nbr1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

74 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice of the genetic truncation allele had an age-dependent increase in bone mass and bone mineral density. Mice homozygous for a floxed allele activated in T cells exhibit decreased ovalbumin-induced inflammation and defective Th2 polarization.

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All GO Annotations

28
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

815
Tissues

83
cDNA Data

18
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NBR1

Xenbase nbr1

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All Sequences

115
RefSeq

28
UniProt

12
CCDS

CCDS25475.1, CCDS56810.1, CCDS56811.1

Ensembl

ENSMUSG00000017119 (Evidence)
NCBI Gene

17966

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017119	Ensembl Gene Model \| MGI Sequence Detail	29803	C57BL/6J	± kb
transcript	ENSMUST00000071537	Ensembl \| MGI Sequence Detail	3239	Not Applicable
polypeptide	ENSMUSP00000071467	Ensembl \| MGI Sequence Detail	988	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000011015 next to BRCA1 gene 1 protein

(term hierarchy)
InterPro Domains

IPR013783 Immunoglobulin-like fold

IPR034852 NBR1, PB1 domain

IPR032350 Next to BRCA1, central domain

IPR000270 PB1 domain

IPR009060 UBA-like superfamily

IPR015940 Ubiquitin-associated domain

IPR000433 Zinc finger, ZZ-type

IPR043145 Zinc finger, ZZ-type superfamily

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All nucleic 24

Genomic 4

cDNA 18

Primer pair 1

Other 1

Microarray probesets 4

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MGD-MRK-37542

Summaries

All 69

Developmental Gene Expression 7

Gene Ontology 10

Phenotypes 26
Earliest

J:37713 Chambers JA, et al., Isolation of the murine Nbr1 gene adjacent to the murine Brca1 gene. Genomics. 1996 Dec 15;38(3):305-13
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nbr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105136	Chr11:101442961-101443010 (+)	11 bp
Tssr105137	Chr11:101443014-101443033 (+)	49 bp
Tssr105138	Chr11:101443217-101443252 (+)	260 bp
Tssr105139	Chr11:101443675-101443700 (+)	713 bp
Tssr105140	Chr11:101444634-101444650 (+)	1,667 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24