Mobp MGI Mouse Gene Detail - MGI:108511 - myelin-associated oligodendrocytic basic protein

Symbol

Mobp
Name

myelin-associated oligodendrocytic basic protein
Synonyms

MOBP155

Feature Type

protein coding gene
IDs

MGI:108511
NCBI Gene: 17433
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr9:119978773-120010550 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 71.41 cM
Mapping Data

6 experiments

SNPs within 2kb

1169 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108511	protein coding gene	Chr9:119978740-120010554 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035433	protein coding gene	Chr9:122977142-123008750 (+)
A/J	MGP_AJ_G0035414	protein coding gene	Chr9:118366858-118398443 (+)
AKR/J	MGP_AKRJ_G0035347	protein coding gene	Chr9:121478903-121510443 (+)
BALB/cJ	MGP_BALBcJ_G0035410	protein coding gene	Chr9:118264067-118295674 (+)
C3H/HeJ	MGP_C3HHeJ_G0035118	protein coding gene	Chr9:121948092-121979679 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035933	protein coding gene	Chr9:126339997-126371565 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032815	protein coding gene	Chr9:115568652-115598472 (+)
CAST/EiJ	MGP_CASTEiJ_G0034422	protein coding gene	Chr9:121955452-121988032 (+)
CBA/J	MGP_CBAJ_G0035085	protein coding gene	Chr9:131054340-131086174 (+)
DBA/2J	MGP_DBA2J_G0035244	protein coding gene	Chr9:117819135-117850663 (+)
FVB/NJ	MGP_FVBNJ_G0035191	protein coding gene	Chr9:116707618-116738961 (+)
LP/J	MGP_LPJ_G0035323	protein coding gene	Chr9:123311191-123342795 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035232	protein coding gene	Chr9:132001366-132032933 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035952	protein coding gene	Chr9:121873047-121905192 (+)
PWK/PhJ	MGP_PWKPhJ_G0034127	protein coding gene	Chr9:118262966-118294749 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033963	protein coding gene	Chr9:121962876-121994916 (+)
WSB/EiJ	MGP_WSBEiJ_G0034542	protein coding gene	Chr9:121754510-121786106 (+)

Human Ortholog

MOBP, myelin associated oligodendrocyte basic protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MOBP, myelin associated oligodendrocyte basic protein
Links

HGNC:7189

NCBI Gene ID: 4336

neXtProt AC: NX_Q13875

UniProt: Q13875
Chr Location

3p22.1; chr3:39467198-39529497 (+) GRCh38

MGI Vertebrate Homology

Mobp stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MOBP
Gene Tree

Mobp

Diseases

1 with human MOBP associations

				Human Disease	Mouse Models
				frontotemporal dementia IDs frontotemporal dementia DOID:9255 MESH:C563003 OMIM:600274 ORDO:282 UMLS_CUI:C0520716

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Endonuclease-mediated

2
Gene trapped

20
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for one null allele show abnormal myelin arrangements but do not exhibit an overt behavorial phenotype. Mice homozygous for another allele have normal myelin.

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All GO Annotations

7
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

931
Tissues

63
cDNA Data

16
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

62
RefSeq

9
UniProt

1
CCDS

CCDS23626.1, CCDS40808.1

Ensembl

ENSMUSG00000032517 (Evidence)
NCBI Gene

17433

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032517	Ensembl Gene Model \| MGI Sequence Detail	31778	C57BL/6J	± kb
transcript	ENSMUST00000068698	Ensembl \| MGI Sequence Detail	1536	Not Applicable
polypeptide	ENSMUSP00000071084	Ensembl \| MGI Sequence Detail	170	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010510 myelin-associated oligodendrocyte basic protein

(term hierarchy)
InterPro Domains

IPR041282 FYVE-type zinc finger

IPR051745 Intracellular Transport Effector

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All nucleic 31

cDNA 18

Primer pair 10

Other 3

Microarray probesets 13

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MGD-MRK-37555, MGI:2143124, MGI:2143130, MGI:2143445

Summaries

All 54

Developmental Gene Expression 12

Gene Ontology 7

Phenotypes 9
Earliest

J:31411 Holz A, et al., Molecular and developmental characterization of novel cDNAs of the myelin-associated/oligodendrocytic basic protein. J Neurosci. 1996 Jan 15;16(2):467-77
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Mobp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87716	Chr9:119978799-119978814 (+)	34 bp
Tssr87717	Chr9:119997452-119997460 (+)	18,683 bp
Tssr87718	Chr9:120003955-120003966 (+)	25,188 bp
Tssr87719	Chr9:120004028-120004042 (+)	25,262 bp
Tssr87720	Chr9:120004092-120004110 (+)	25,328 bp
Tssr87721	Chr9:120004541-120004551 (+)	25,773 bp
Tssr87722	Chr9:120008731-120008743 (+)	29,964 bp
Tssr87723	Chr9:120008782-120008793 (+)	30,015 bp
Tssr87724	Chr9:120008930-120008939 (+)	30,162 bp
Tssr87725	Chr9:120008969-120008980 (+)	30,202 bp
Tssr87726	Chr9:120008996-120009007 (+)	30,229 bp
Tssr87727	Chr9:120009080-120009092 (+)	30,313 bp
Tssr87728	Chr9:120009105-120009118 (+)	30,339 bp
Tssr87729	Chr9:120009328-120009343 (+)	30,563 bp
Tssr87730	Chr9:120009351-120009364 (+)	30,585 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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