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Thrsp Gene Detail
Summary
  • Symbol
    Thrsp
  • Name
    thyroid hormone responsive
  • Synonyms
    S14, Spot 14
  • Feature Type
    protein coding gene
  • IDs
    MGI:109126
    NCBI Gene: 21835
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:97062140-97066757 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 53.49 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    319 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109126
 protein coding gene Chr7:97062140-97066937 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032524
 protein coding gene Chr7:100106414-100111183 (-)
A/J MGP_AJ_G0032498
 protein coding gene Chr7:97623663-97628416 (-)
AKR/J MGP_AKRJ_G0032434
 protein coding gene Chr7:99945584-99950350 (-)
BALB/cJ MGP_BALBcJ_G0032509
 protein coding gene Chr7:97315718-97320491 (-)
C3H/HeJ MGP_C3HHeJ_G0032224
 protein coding gene Chr7:100301250-100305989 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033007
 protein coding gene Chr7:103999940-104004734 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030002
 protein coding gene Chr7:100079836-100084592 (-)
CAST/EiJ MGP_CASTEiJ_G0031551
 protein coding gene Chr7:91815072-91819657 (-)
CBA/J MGP_CBAJ_G0032191
 protein coding gene Chr7:107514582-107519321 (-)
DBA/2J MGP_DBA2J_G0032343
 protein coding gene Chr7:95985665-95990404 (-)
FVB/NJ MGP_FVBNJ_G0032299
 protein coding gene Chr7:95769854-95774609 (-)
LP/J MGP_LPJ_G0032432
 protein coding gene Chr7:101432635-101437386 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032332
 protein coding gene Chr7:109056096-109060852 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033029
 protein coding gene Chr7:99238383-99243122 (-)
PWK/PhJ MGP_PWKPhJ_G0031269
 protein coding gene Chr7:89044202-89048806 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031112
 protein coding gene Chr7:86474434-86479237 (-)
WSB/EiJ MGP_WSBEiJ_G0031668
 protein coding gene Chr7:99876561-99881354 (-)



Homology
more
  • Human Ortholog
    THRSP, thyroid hormone responsive
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THRSP, thyroid hormone responsive
  • Synonyms
    Lpgp, LPGP1, S14, SPOT14, THRP
  • Links
    NCBI Gene ID: 7069
    neXtProt AC: NX_Q92748
    UniProt: Q92748

  • Chr Location
    11q14.1; chr11:78063861-78068351 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Thrsp mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased triglyceride during lactation and in milk produced as well as decreased de novo lipid biosynthesis in mammary tissue.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    918
  • Tissues
    180
  • cDNA Data
    203
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21835 NCBI Gene Model | MGI Sequence Detail 4618 C57BL/6J ±  kb
    transcript NM_009381 RefSeq | MGI Sequence Detail 1124 C57BL/6  
    polypeptide Q62264 UniProt | EBI | MGI Sequence Detail 150 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 213
      Genomic 3
      cDNA 204
      Primer pair 4
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38170
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 8
      Phenotypes 34
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:357360 Oelkrug R, et al., Maternal thyroid hormone receptor beta activation in mice sparks brown fat thermogenesis in the offspring. Nat Commun. 2023 Oct 24;14(1):6742
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory