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Rasgrf2 Gene Detail
Summary
  • Symbol
    Rasgrf2
  • Name
    RAS protein-specific guanine nucleotide-releasing factor 2
  • Synonyms
    6330417G04Rik, Grf2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109137
    NCBI Gene: 19418
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:92028519-92268164 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 47.43 cM, cytoband C3-D1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6357 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109137
 protein coding gene Chr13:92028519-92268584 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020811
 protein coding gene Chr13:93170922-93413683 (-)
A/J MGP_AJ_G0020765
 protein coding gene Chr13:89728082-89971722 (-)
AKR/J MGP_AKRJ_G0020738
 protein coding gene Chr13:92448452-92688516 (-)
BALB/cJ MGP_BALBcJ_G0020761
 protein coding gene Chr13:90369735-90611478 (-)
C3H/HeJ MGP_C3HHeJ_G0020555
 protein coding gene Chr13:92148020-92384593 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021198
 protein coding gene Chr13:96026174-96267020 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018766
 protein coding gene Chr13:85675178-85899909 (-)
CAST/EiJ MGP_CASTEiJ_G0020074
 protein coding gene Chr13:91419647-91655144 (-)
CBA/J MGP_CBAJ_G0020514
 protein coding gene Chr13:99832303-100091792 (-)
DBA/2J MGP_DBA2J_G0020639
 protein coding gene Chr13:89484013-89720389 (-)
FVB/NJ MGP_FVBNJ_G0020619
 protein coding gene Chr13:88305657-88538845 (-)
LP/J MGP_LPJ_G0020712
 protein coding gene Chr13:93291662-93538225 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020648
 protein coding gene Chr13:100340799-100600318 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021238
 protein coding gene Chr13:91848460-92082435 (-)
PWK/PhJ MGP_PWKPhJ_G0019826
 protein coding gene Chr13:88231784-88467355 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019650
 protein coding gene Chr13:88112281-88352749 (-)
WSB/EiJ MGP_WSBEiJ_G0020131
 protein coding gene Chr13:92330360-92572364 (-)



Homology
more
  • Human Ortholog
    RASGRF2, Ras protein specific guanine nucleotide releasing factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASGRF2, Ras protein specific guanine nucleotide releasing factor 2
  • Synonyms
    GRF2, RAS-GRF2
  • Links
    NCBI Gene ID: 5924
    neXtProt AC: NX_O14827
    UniProt: O14827

  • Chr Location
    5q14.1; chr5:80960363-81230162 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit decreased Il2 and TNF-alpha production in stimulated T cells. Mice homozygous for mutations in both Rasgrf1 and Rasgrf2 exhibit no additional abnormalities than those observed in the Rasgrf1 mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    8
  • cDNA Data
    21
  • Literature Summary
    2
Sequences &
Gene Models
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  • All Sequences
    40
  • RefSeq
    6
  • UniProt
    3
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021708 Ensembl Gene Model | MGI Sequence Detail 239646 C57BL/6J ±  kb
transcript ENSMUST00000151408 Ensembl | MGI Sequence Detail 7764 Not Applicable  
polypeptide ENSMUSP00000116892 Ensembl | MGI Sequence Detail 1189 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013757 Ras-specific guanine nucleotide-releasing factor 2
    (term hierarchy)
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR035899 Dbl homology (DH) domain superfamily
    IPR051092 FYVE, RhoGEF and PH domain-containing
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
    IPR019804 Ras guanine-nucleotide exchange factor, conserved site
    IPR023578 Ras guanine nucleotide exchange factor domain superfamily
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR008937 Ras-like guanine nucleotide exchange factor
    IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
  • GlyGen
    P70392 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)
Molecular
Reagents
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  • All nucleic 22
    Genomic 1
    cDNA 21

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-38181, MGI:1917989, MGI:2145404
References
more
  • Summaries
    All 84
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 49
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:357486 Xie H, et al., Multifocal fluorescence video-rate imaging of centimetre-wide arbitrarily shaped brain surfaces at micrometric resolution. Nat Biomed Eng. 2024 Jun;8(6):740-753
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory