Oxtr MGI Mouse Gene Detail - MGI:109147

Symbol

Oxtr
Name

oxytocin receptor
Synonyms

OTR

Feature Type

protein coding gene
IDs

MGI:109147
NCBI Gene: 18430
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr6:112450644-112466904 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 52.27 cM, cytoband E3
Mapping Data

1 experiment

SNPs within 2kb

644 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109147	protein coding gene	Chr6:112450644-112467800 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031108	protein coding gene	Chr6:114918413-114934547 (-)
A/J	MGP_AJ_G0031077	protein coding gene	Chr6:110536446-110552624 (-)
AKR/J	MGP_AKRJ_G0031008	protein coding gene	Chr6:113512502-113528725 (-)
BALB/cJ	MGP_BALBcJ_G0031088	protein coding gene	Chr6:110491619-110508656 (-)
C3H/HeJ	MGP_C3HHeJ_G0030620	protein coding gene	Chr6:70782563-70798790 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031547	protein coding gene	Chr6:117933775-117951272 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028711	protein coding gene	Chr6:107566414-107583017 (-)
CAST/EiJ	MGP_CASTEiJ_G0030195	protein coding gene	Chr6:113947717-113967421 (-)
CBA/J	MGP_CBAJ_G0030774	protein coding gene	Chr6:122568491-122584691 (-)
DBA/2J	MGP_DBA2J_G0030927	protein coding gene	Chr6:109642280-109658492 (-)
FVB/NJ	MGP_FVBNJ_G0030881	protein coding gene	Chr6:108626763-108646153 (-)
LP/J	MGP_LPJ_G0031007	protein coding gene	Chr6:114976590-114995089 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030915	protein coding gene	Chr6:126878883-126897654 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031574	protein coding gene	Chr6:113530633-113546845 (-)
PWK/PhJ	MGP_PWKPhJ_G0029911	protein coding gene	Chr6:108579111-108596292 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029739	protein coding gene	Chr6:112328694-112348434 (-)
WSB/EiJ	MGP_WSBEiJ_G0030279	protein coding gene	Chr6:113891850-113909054 (-)

Human Ortholog

OXTR, oxytocin receptor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OXTR, oxytocin receptor
Synonyms

OT-R, OTR
Links

HGNC:8529

NCBI Gene ID: 5021

neXtProt AC: NX_P30559

UniProt: P30559
Chr Location

3p25.3; chr3:8741269-8769628 (-) GRCh38

MGI Vertebrate Homology

Oxtr stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: OXTR
Gene Tree

Oxtr

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Phenotype Summary

23 phenotypes from 6 alleles in 6 genetic backgrounds
112 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Endonuclease-mediated

7
Spontaneous

1
Targeted

14
Transgenic

1
Genomic Mutations

1 involving Oxtr
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null females fail to lactate and exhibit decreased maternal behavior. Males exhibit an increase in aggression, hypoactivity and vocalization in response to social isolation, and social amnesia.

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All GO Annotations

71
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1484
Tissues

89
cDNA Data

13
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

ZFIN oxtra, oxtrb

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All Sequences

49
RefSeq

6
UniProt

6
CCDS

CCDS39588.1

Ensembl

ENSMUSG00000049112 (Evidence)
NCBI Gene

18430

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049112	Ensembl Gene Model \| MGI Sequence Detail	16261	C57BL/6J	± kb
transcript	ENSMUST00000053306	Ensembl \| MGI Sequence Detail	4704	Not Applicable
polypeptide	ENSMUSP00000051132	Ensembl \| MGI Sequence Detail	388	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000001635 oxytocin receptor

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR002062 Oxytocin receptor

IPR001817 Vasopressin receptor
GlyGen

P97926 2 sites

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All nucleic 20

Genomic 3

cDNA 13

Primer pair 4

Microarray probesets 3

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MGD-MRK-38191

Summaries

All 167

Developmental Gene Expression 18

Gene Ontology 6

Phenotypes 112
Earliest

J:33726 Kaluz S, et al., Heterogeneity in the third intracytoplasmic region of the oxytocin receptor-encoding gene. Gene. 1996 Jun 26;172(2):313-4
Latest

J:358178 Zhang Y, et al., Long-term mesoscale imaging of 3D intercellular dynamics across a mammalian organ. Cell. 2024 Oct 17;187(21):6104-6122.e25

TSS for Oxtr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr62408	Chr6:112468003-112468005 (-)	-1,100 bp
Tssr62407	Chr6:112467792-112467805 (-)	-895 bp
Tssr62406	Chr6:112467765-112467790 (-)	-874 bp
Tssr62405	Chr6:112467747-112467764 (-)	-852 bp
Tssr62404	Chr6:112466780-112466789 (-)	119 bp
Tssr62403	Chr6:112465922-112465931 (-)	977 bp
Tssr62402	Chr6:112465880-112465896 (-)	1,016 bp
Tssr62401	Chr6:112452715-112452720 (-)	14,186 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24