Mnt MGI Mouse Gene Detail - MGI:109150

Symbol

Mnt
Name

max binding protein
Synonyms

bHLHd3, Rox

Feature Type

protein coding gene
IDs

MGI:109150
NCBI Gene: 17428
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:74721746-74736551 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.76 cM, cytoband B-C
Mapping Data

5 experiments

SNPs within 2kb

328 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109150	protein coding gene	Chr11:74721651-74736551 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018699	protein coding gene	Chr11:75545246-75562004 (+)
A/J	MGP_AJ_G0018665	protein coding gene	Chr11:72746890-72761691 (+)
AKR/J	MGP_AKRJ_G0018635	protein coding gene	Chr11:74952539-74968441 (+)
BALB/cJ	MGP_BALBcJ_G0018639	protein coding gene	Chr11:73114340-73129123 (+)
C3H/HeJ	MGP_C3HHeJ_G0018452	protein coding gene	Chr11:74956285-74970249 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019090	protein coding gene	Chr11:77917547-77930867 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016725	protein coding gene	Chr11:69772099-69787159 (+)
CAST/EiJ	MGP_CASTEiJ_G0018006	protein coding gene	Chr11:75332270-75348556 (+)
CBA/J	MGP_CBAJ_G0018422	protein coding gene	Chr11:81339277-81354962 (+)
DBA/2J	MGP_DBA2J_G0018531	protein coding gene	Chr11:72345990-72358508 (+)
FVB/NJ	MGP_FVBNJ_G0018521	protein coding gene	Chr11:71916886-71931577 (+)
LP/J	MGP_LPJ_G0018602	protein coding gene	Chr11:76143686-76156149 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018547	protein coding gene	Chr11:81946751-81961535 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019130	protein coding gene	Chr11:75144858-75159576 (+)
PWK/PhJ	MGP_PWKPhJ_G0017777	protein coding gene	Chr11:73044042-73058903 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017568	protein coding gene	Chr11:74712380-74728560 (+)
WSB/EiJ	MGP_WSBEiJ_G0018059	protein coding gene	Chr11:74950451-74965235 (+)

Human Ortholog

MNT, MAX network transcriptional repressor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MNT, MAX network transcriptional repressor
Synonyms

bHLHd3, lncRNA-HAL, MAD6, MXD6, ROX
Links

HGNC:7188

NCBI Gene ID: 4335

neXtProt AC: NX_Q99583

UniProt: Q99583
Chr Location

17p13.3; chr17:2384073-2401104 (-) GRCh38

MGI Vertebrate Homology

Mnt stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MNT
Gene Tree

Mnt

Diseases

1 with Mnt mouse models

Human Disease

Mouse Models

Miller-Dieker lissencephaly syndrome

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

23 phenotypes from 4 alleles in 4 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

22
Targeted

7
Genomic Mutations

2 involving Mnt
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Most homozygotes for a targeted null mutation are runted at birth and die within a few days, while mutant fibroblasts show abnormal cell cycling. Those homozygotes that survive are fertile and attain normal Heterozygotes for a conditional mammary epithelial specific knockout develop adenocarcinomas.

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All GO Annotations

27
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

811
Tissues

93
cDNA Data

76
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MNT

Xenbase mnt

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All Sequences

47
RefSeq

8
UniProt

3
CCDS

CCDS25037.1

Ensembl

ENSMUSG00000000282 (Evidence)
NCBI Gene

17428

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000282	Ensembl Gene Model \| MGI Sequence Detail	14806	C57BL/6J	± kb
transcript	ENSMUST00000000291	Ensembl \| MGI Sequence Detail	4590	Not Applicable
polypeptide	ENSMUSP00000000291	Ensembl \| MGI Sequence Detail	591	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010500 Max-binding protein MNT

(term hierarchy)
InterPro Domains

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
GlyGen

O08789 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 82

Genomic 3

cDNA 77

Primer pair 2

Microarray probesets 4

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MGD-MRK-38194

Summaries

All 62

Developmental Gene Expression 10

Diseases 1

Gene Ontology 6

Phenotypes 25
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:334557 Nguyen HV, et al., MNT suppresses T cell apoptosis via BIM and is critical for T lymphomagenesis. Cell Death Differ. 2023 Apr;30(4):1018-1032

TSS for Mnt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102911	Chr11:74721714-74721729 (+)	-24 bp
Tssr102912	Chr11:74721733-74721746 (+)	-6 bp
Tssr102913	Chr11:74721761-74721831 (+)	50 bp
Tssr102914	Chr11:74722040-74722104 (+)	326 bp
Tssr102915	Chr11:74730062-74730073 (+)	8,322 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24