Gng5 MGI Mouse Gene Detail - MGI:109164 - G protein subunit gamma 5

Symbol

Gng5
Name

G protein subunit gamma 5
Synonyms

G(y)5

Feature Type

protein coding gene
IDs

MGI:109164
NCBI Gene: 14707
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:146205591-146211298 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 71.54 cM
Mapping Data

1 experiment

SNPs within 2kb

273 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109164	protein coding gene	Chr3:146205562-146211327 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027973	protein coding gene	Chr3:150021760-150027542 (+)
A/J	MGP_AJ_G0027932	protein coding gene	Chr3:144628141-144633906 (+)
AKR/J	MGP_AKRJ_G0027898	protein coding gene	Chr3:148490822-148498491 (+)
BALB/cJ	MGP_BALBcJ_G0027944	protein coding gene	Chr3:144453808-144459573 (+)
C3H/HeJ	MGP_C3HHeJ_G0027674	protein coding gene	Chr3:148858000-148863765 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028387	protein coding gene	Chr3:155043501-155050318 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025725	protein coding gene	Chr3:139689614-139695451 (+)
CAST/EiJ	MGP_CASTEiJ_G0027127	protein coding gene	Chr3:148841071-148848255 (+)
CBA/J	MGP_CBAJ_G0027649	protein coding gene	Chr3:160553491-160559256 (+)
DBA/2J	MGP_DBA2J_G0027789	protein coding gene	Chr3:143782161-143787926 (+)
FVB/NJ	MGP_FVBNJ_G0027756	protein coding gene	Chr3:141197988-141203753 (+)
LP/J	MGP_LPJ_G0027900	protein coding gene	Chr3:151405259-151410971 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027789	protein coding gene	Chr3:168831455-168839618 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028446	protein coding gene	Chr3:148078499-148084355 (+)
PWK/PhJ	MGP_PWKPhJ_G0026850	protein coding gene	Chr3:143637513-143643962 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026678	protein coding gene	Chr3:146243294-146249923 (+)
WSB/EiJ	MGP_WSBEiJ_G0027207	protein coding gene	Chr3:149054712-149060477 (+)

Human Ortholog

GNG5, G protein subunit gamma 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GNG5, G protein subunit gamma 5
Links

HGNC:4408

NCBI Gene ID: 2787

neXtProt AC: NX_P63218

UniProt: P63218
Chr Location

1p22.3; chr1:84498323-84506581 (-) GRCh38

MGI Vertebrate Homology

Gng5 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: GNG5
Gene Tree

Gng5

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References

1 with disease annotations

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
3 images
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

1
Gene trapped

8
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Gng5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit abnormal headfolds, hypoplastic pharyngeal arches, severe cardiac defects including absence of formation of the right ventricle and outflow tract, and complete embryonic lethality.

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

729
Tissues

16
cDNA Data

6
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gng5

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All Sequences

41
RefSeq

2
UniProt

3
CCDS

CCDS17903.1

Ensembl

ENSMUSG00000068523 (Evidence)
NCBI Gene

14707

			Length	Strain/Species	Flank
genomic	14707	NCBI Gene Model \| MGI Sequence Detail	5708	C57BL/6J	± kb
transcript	NM_010318	RefSeq \| MGI Sequence Detail	535	C57BL/6
polypeptide	Q80SZ7	UniProt \| EBI \| MGI Sequence Detail	68	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008110 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

(term hierarchy)
InterPro Domains

IPR015898 G-protein gamma-like domain

IPR036284 G-protein gamma-like domain superfamily

IPR001770 G-protein, gamma subunit

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All nucleic 8

cDNA 7

Primer pair 1

Microarray probesets 6

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MGD-MRK-38208

Summaries

All 35

Developmental Gene Expression 5

Diseases 1

Gene Ontology 6

Phenotypes 8
Earliest

J:34526 Williams CJ, et al., G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development. Mol Reprod Dev. 1996 Jul;44(3):315-23
Latest

J:358423 Li C, et al., GNG5 is a novel regulator of Abeta42 production in Alzheimer's disease. Cell Death Dis. 2024 Nov 11;15(11):815

TSS for Gng5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr32351	Chr3:146205460-146205519 (+)	-101 bp
Tssr32352	Chr3:146205583-146205598 (+)	0 bp
Tssr32353	Chr3:146205605-146205641 (+)	32 bp
Tssr32354	Chr3:146205826-146205847 (+)	246 bp
Tssr32355	Chr3:146205886-146205889 (+)	297 bp
Tssr32356	Chr3:146205916-146205940 (+)	337 bp
Tssr32357	Chr3:146205944-146205966 (+)	364 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24