Ncs1 MGI Mouse Gene Detail - MGI:109166 - neuronal calcium sensor 1

Symbol

Ncs1
Name

neuronal calcium sensor 1
Synonyms

9430075O15Rik, A730032G13Rik, Freq, NCS-1

Feature Type

protein coding gene
IDs

MGI:109166
NCBI Gene: 14299
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:31135835-31186001 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 21.81 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

1438 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109166	protein coding gene	Chr2:31135766-31186001 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025583	protein coding gene	Chr2:29563623-29613505 (+)
A/J	MGP_AJ_G0025561	protein coding gene	Chr2:28360855-28412187 (+)
AKR/J	MGP_AKRJ_G0025530	protein coding gene	Chr2:29325543-29380091 (+)
BALB/cJ	MGP_BALBcJ_G0025557	protein coding gene	Chr2:28491943-28541826 (+)
C3H/HeJ	MGP_C3HHeJ_G0025318	protein coding gene	Chr2:29253751-29304084 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026002	protein coding gene	Chr2:30518208-30571609 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023410	protein coding gene	Chr2:27121842-27172314 (+)
CAST/EiJ	MGP_CASTEiJ_G0024780	protein coding gene	Chr2:29191332-29241847 (+)
CBA/J	MGP_CBAJ_G0025295	protein coding gene	Chr2:31605030-31657199 (+)
DBA/2J	MGP_DBA2J_G0025428	protein coding gene	Chr2:28132775-28184136 (+)
FVB/NJ	MGP_FVBNJ_G0025391	protein coding gene	Chr2:27980181-28032126 (+)
LP/J	MGP_LPJ_G0025514	protein coding gene	Chr2:29469015-29519932 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025421	protein coding gene	Chr2:31377356-31429671 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026060	protein coding gene	Chr2:29245258-29296512 (+)
PWK/PhJ	MGP_PWKPhJ_G0024527	protein coding gene	Chr2:28022337-28074684 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024327	protein coding gene	Chr2:29386698-29442870 (+)
WSB/EiJ	MGP_WSBEiJ_G0024848	protein coding gene	Chr2:29417049-29469532 (+)

Human Ortholog

NCS1, neuronal calcium sensor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NCS1, neuronal calcium sensor 1
Synonyms

FLUP, FREQ
Links

HGNC:3953

NCBI Gene ID: 23413

neXtProt AC: NX_P62166

UniProt: P62166
Chr Location

9q34.11; chr9:130172404-130237303 (+) GRCh38

MGI Vertebrate Homology

Ncs1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NCS1
Gene Tree

Ncs1

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

2
Targeted

7
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

32
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

748
Tissues

35
cDNA Data

9
Literature Summary

8

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ncs1

ZFIN ncs1a, ncs1b

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All Sequences

41
RefSeq

4
UniProt

2
CCDS

CCDS15896.1

Ensembl

ENSMUSG00000062661 (Evidence)
NCBI Gene

14299

			Length	Strain/Species	Flank
genomic	ENSMUSG00000062661	Ensembl Gene Model \| MGI Sequence Detail	50167	C57BL/6J	± kb
transcript	ENSMUST00000000199	Ensembl \| MGI Sequence Detail	4653	Not Applicable
polypeptide	ENSMUSP00000000199	Ensembl \| MGI Sequence Detail	190	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007659 neuronal calcium sensor 1

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR028846 Recoverin family

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All nucleic 9

cDNA 9

Microarray probesets 6

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MGD-MRK-38210, MGI:1924545, MGI:2139059

Summaries

All 63

Developmental Gene Expression 8

Gene Ontology 8

Phenotypes 21
Earliest

J:38125 Olafsson P, et al., The Ca2+ binding protein, frequenin is a nervous system-specific protein in mouse preferentially localized in neurites. Brain Res Mol Brain Res. 1997 Feb;44(1):73-82
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ncs1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17173	Chr2:31135813-31135912 (+)	28 bp
Tssr17174	Chr2:31135917-31135928 (+)	88 bp
Tssr17175	Chr2:31136054-31136067 (+)	226 bp
Tssr17176	Chr2:31136081-31136132 (+)	272 bp
Tssr17177	Chr2:31168045-31168056 (+)	32,216 bp
Tssr17178	Chr2:31174156-31174169 (+)	38,328 bp
Tssr17179	Chr2:31183197-31183206 (+)	47,367 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24