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Dab2 Gene Detail
Summary
  • Symbol
    Dab2
  • Name
    disabled 2, mitogen-responsive phosphoprotein
  • Synonyms
    5730435J12Rik, D15Wsu122e, D630005B22Rik, p96
  • Feature Type
    protein coding gene
  • IDs
    MGI:109175
    NCBI Gene: 13132
  • Alliance
    gene page
  • Transcription Start Sites
    38 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:6329269-6470193 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 2.15 cM, cytoband A2
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3774 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109175
 protein coding gene Chr15:6329269-6470196 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021695
 protein coding gene Chr15:3251791-3409978 (+)
A/J MGP_AJ_G0021656
 protein coding gene Chr15:3218989-3361062 (+)
AKR/J MGP_AKRJ_G0021634
 protein coding gene Chr15:3214396-3371282 (+)
BALB/cJ MGP_BALBcJ_G0021663
 protein coding gene Chr15:3132594-3279402 (+)
C3H/HeJ MGP_C3HHeJ_G0021439
 protein coding gene Chr15:3248495-3398792 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022102
 protein coding gene Chr15:3412063-3565795 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019639
 protein coding gene Chr15:2885386-3023530 (+)
CAST/EiJ MGP_CASTEiJ_G0020955
 protein coding gene Chr15:3226913-3379295 (+)
CBA/J MGP_CBAJ_G0021408
 protein coding gene Chr15:3448286-3620727 (+)
DBA/2J MGP_DBA2J_G0021532
 protein coding gene Chr15:3154673-3296885 (+)
FVB/NJ MGP_FVBNJ_G0021510
 protein coding gene Chr15:3070550-3216898 (+)
LP/J MGP_LPJ_G0021600
 protein coding gene Chr15:3180588-3341466 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021535
 protein coding gene Chr15:3672171-3831360 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022125
 protein coding gene Chr15:3236217-3392799 (+)
PWK/PhJ MGP_PWKPhJ_G0020698
 protein coding gene Chr15:3145718-3293121 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020536
 protein coding gene Chr15:3154751-3310462 (+)
WSB/EiJ MGP_WSBEiJ_G0021011
 protein coding gene Chr15:3161611-3309868 (+)



Homology
more
  • Human Ortholog
    DAB2, DAB adaptor protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DAB2, DAB adaptor protein 2
  • Synonyms
    DOC-2, DOC2
  • Links
    NCBI Gene ID: 1601
    neXtProt AC: NX_P98082
    UniProt: P98082

  • Chr Location
    5p13.1; chr5:39371675-39462300 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 5 alleles in 4 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit abnormal primitive endoderm structure and/or function, lack a proamniotic cavity and die prior to embryonic day 9.5. A conditional mutant survives, but shows kidney proximal tubule abnormality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    115
  • GO References
    32
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1003
  • Tissues
    151
  • cDNA Data
    239
  • Literature Summary
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022150 Ensembl Gene Model | MGI Sequence Detail 140925 C57BL/6J ±  kb
    transcript ENSMUST00000080880 Ensembl | MGI Sequence Detail 4663 Not Applicable  
    polypeptide ENSMUSP00000079689 Ensembl | MGI Sequence Detail 766 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 248
      Genomic 1
      cDNA 241
      Primer pair 6

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-35708, MGD-MRK-38219, MGI:107243, MGI:1917805, MGI:2145932, MGI:2146101, MGI:3045240
    References
    more
    • Summaries
      All 126
      Developmental Gene Expression 43
      Gene Ontology 32
      Phenotypes 25
    • Earliest
      J:37850 Xu XX, et al., Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product. J Biol Chem. 1995 Jun 9;270(23):14184-91
    • Latest
      J:354194 Oikonomakos I, et al., In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells. Stem Cell Reports. 2024 Sep 10;19(9):1289-1303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory