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Cpt2 Gene Detail
Summary
  • Symbol
    Cpt2
  • Name
    carnitine palmitoyltransferase 2
  • Synonyms
    CPT II, CPTII
  • Feature Type
    protein coding gene
  • IDs
    MGI:109176
    NCBI Gene: 12896
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:107761179-107780786 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 50.18 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    614 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109176
 protein coding gene Chr4:107761178-107780807 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028545
 protein coding gene Chr4:108608381-108628079 (-)
A/J MGP_AJ_G0028508
 protein coding gene Chr4:104707848-104727469 (-)
AKR/J MGP_AKRJ_G0028455
 protein coding gene Chr4:107281752-107301241 (-)
BALB/cJ MGP_BALBcJ_G0028527
 protein coding gene Chr4:104908141-104928401 (-)
C3H/HeJ MGP_C3HHeJ_G0028241
 protein coding gene Chr4:108023975-108044000 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028967
 protein coding gene Chr4:112500516-112524972 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026258
 protein coding gene Chr4:100016006-100033921 (-)
CAST/EiJ MGP_CASTEiJ_G0027677
 protein coding gene Chr4:105858196-105878976 (-)
CBA/J MGP_CBAJ_G0028210
 protein coding gene Chr4:116141503-116168831 (-)
DBA/2J MGP_DBA2J_G0028358
 protein coding gene Chr4:104330606-104350641 (-)
FVB/NJ MGP_FVBNJ_G0028326
 protein coding gene Chr4:103200134-103219843 (-)
LP/J MGP_LPJ_G0028459
 protein coding gene Chr4:108806255-108827091 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028352
 protein coding gene Chr4:121412362-121434386 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029003
 protein coding gene Chr4:107527331-107548200 (-)
PWK/PhJ MGP_PWKPhJ_G0027403
 protein coding gene Chr4:102582545-102602884 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027227
 protein coding gene Chr4:104903408-104926004 (-)
WSB/EiJ MGP_WSBEiJ_G0027758
 protein coding gene Chr4:107707313-107728827 (-)



Homology
more
  • Human Ortholog
    CPT2, carnitine palmitoyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPT2, carnitine palmitoyltransferase 2
  • Synonyms
    CPT1, CPTASE, IIAE4
  • Links
    NCBI Gene ID: 1376
    neXtProt AC: NX_P23786
    UniProt: P23786

  • Chr Location
    1p32.3; chr1:53196792-53214197 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CPT2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    878
  • Tissues
    134
  • cDNA Data
    100
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12896 NCBI Gene Model | MGI Sequence Detail 19608 C57BL/6J ±  kb
    transcript NM_009949 RefSeq | MGI Sequence Detail 2343 C57BL/6  
    polypeptide P52825 UniProt | EBI | MGI Sequence Detail 658 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000005838 carnitine O-palmitoyltransferase 2, mitochondrial
      (term hierarchy)
    • EC
      2.3.1.21
    • InterPro Domains
      IPR000542 Acyltransferase ChoActase/COT/CPT
      IPR042572 Carnitine o-acyltransferase, N-terminal
      IPR023213 Chloramphenicol acetyltransferase-like domain superfamily
      IPR039551 Choline/carnitine acyltransferase domain
      IPR042231 Choline/Carnitine o-acyltransferase, domain 2
    • GlyGen
      P52825 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 108
      Genomic 3
      cDNA 100
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38220, MGI:2140234
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 18
      Gene Ontology 12
      Phenotypes 38
    • Earliest
      J:16140 Gelb BD, Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene. Genomics. 1993 Dec;18(3):651-5
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory