Kifc2 MGI Mouse Gene Detail - MGI:109187 - kinesin family member C2

Symbol

Kifc2
Name

kinesin family member C2

Feature Type

protein coding gene
IDs

MGI:109187
NCBI Gene: 16581
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:76544058-76552396 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 36.23 cM, cytoband D-E
Mapping Data

5 experiments

SNPs within 2kb

169 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109187	protein coding gene	Chr15:76543984-76552396 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022004	protein coding gene	Chr15:76754111-76761583 (+)
A/J	MGP_AJ_G0021962	protein coding gene	Chr15:73948048-73955354 (+)
AKR/J	MGP_AKRJ_G0021945	protein coding gene	Chr15:75954794-75962169 (+)
BALB/cJ	MGP_BALBcJ_G0021971	protein coding gene	Chr15:73973662-73980993 (+)
C3H/HeJ	MGP_C3HHeJ_G0021743	protein coding gene	Chr15:75999931-76007265 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022411	protein coding gene	Chr15:79618666-79625936 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019940	protein coding gene	Chr15:70604288-70612711 (+)
CAST/EiJ	MGP_CASTEiJ_G0021262	protein coding gene	Chr15:76804423-76811782 (+)
CBA/J	MGP_CBAJ_G0021710	protein coding gene	Chr15:82142934-82152246 (+)
DBA/2J	MGP_DBA2J_G0021835	protein coding gene	Chr15:73485223-73492401 (+)
FVB/NJ	MGP_FVBNJ_G0021815	protein coding gene	Chr15:72543192-72550537 (+)
LP/J	MGP_LPJ_G0021906	protein coding gene	Chr15:76842567-76851010 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021840	protein coding gene	Chr15:87474392-87481711 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022431	protein coding gene	Chr15:76229680-76236992 (+)
PWK/PhJ	MGP_PWKPhJ_G0021003	protein coding gene	Chr15:73649909-73657487 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020843	protein coding gene	Chr15:75923291-75931497 (+)
WSB/EiJ	MGP_WSBEiJ_G0021314	protein coding gene	Chr15:76316654-76323976 (+)

Human Ortholog

KIFC2, kinesin family member C2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIFC2, kinesin family member C2
Links

HGNC:29530

NCBI Gene ID: 90990

neXtProt AC: NX_Q96AC6

UniProt: Q96AC6
Chr Location

8q24.3; chr8:144466043-144474202 (+) GRCh38

MGI Vertebrate Homology

Kifc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KIFC2
Gene Tree

Kifc2

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

3
Radiation induced

2
Targeted

4
Genomic Mutations

5 involving Kifc2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available

Mice homozygous for a knock-out allele are viable and fertile with no apparent defects in development or behavior.

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All GO Annotations

16
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

844
Tissues

104
cDNA Data

8
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kifc2

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All Sequences

98
RefSeq

57
UniProt

5
CCDS

CCDS27583.1, CCDS88791.1

Ensembl

ENSMUSG00000004187 (Evidence)
NCBI Gene

16581

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004187	Ensembl Gene Model \| MGI Sequence Detail	8339	C57BL/6J	± kb
transcript	ENSMUST00000004294	Ensembl \| MGI Sequence Detail	3218	Not Applicable
polypeptide	ENSMUSP00000004294	Ensembl \| MGI Sequence Detail	792	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009324 kinesin-like protein KIFC2

(term hierarchy)
InterPro Domains

IPR027640 Kinesin-like protein

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 10

cDNA 8

Primer pair 1

Other 1

Microarray probesets 7

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MGD-MRK-38231

Summaries

All 59

Developmental Gene Expression 6

Diseases 1

Gene Ontology 4

Phenotypes 30
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kifc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131808	Chr15:76544049-76544103 (+)	18 bp
Tssr131809	Chr15:76544528-76544561 (+)	487 bp
Tssr131810	Chr15:76544764-76544810 (+)	729 bp
Tssr131811	Chr15:76551679-76551696 (+)	7,630 bp
Tssr131812	Chr15:76551889-76551900 (+)	7,837 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24