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Pkn2 Gene Detail
Summary
  • Symbol
    Pkn2
  • Name
    protein kinase N2
  • Synonyms
    6030436C20Rik, PRK2, Prkcl2, Stk7
  • Feature Type
    protein coding gene
  • IDs
    MGI:109211
    NCBI Gene: 109333
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:142496663-142587765 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 66.69 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1802 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109211
 protein coding gene Chr3:142496663-142587765 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027948
 protein coding gene Chr3:146003715-146100229 (-)
A/J MGP_AJ_G0027905
 protein coding gene Chr3:140833172-140925161 (-)
AKR/J MGP_AKRJ_G0027871
 protein coding gene Chr3:144591863-144684412 (-)
BALB/cJ MGP_BALBcJ_G0027917
 protein coding gene Chr3:140644263-140732881 (-)
C3H/HeJ MGP_C3HHeJ_G0027647
 protein coding gene Chr3:144906319-144998683 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028361
 protein coding gene Chr3:151071724-151169939 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025699
 protein coding gene Chr3:136049044-136143501 (-)
CAST/EiJ MGP_CASTEiJ_G0027103
 protein coding gene Chr3:144886764-144975460 (-)
CBA/J MGP_CBAJ_G0027624
 protein coding gene Chr3:156356522-156446594 (-)
DBA/2J MGP_DBA2J_G0027763
 protein coding gene Chr3:140002086-140096165 (-)
FVB/NJ MGP_FVBNJ_G0027730
 protein coding gene Chr3:137423418-137514526 (-)
LP/J MGP_LPJ_G0027873
 protein coding gene Chr3:147432698-147530074 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027762
 protein coding gene Chr3:164643132-164755407 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028419
 protein coding gene Chr3:144211211-144304752 (-)
PWK/PhJ MGP_PWKPhJ_G0026827
 protein coding gene Chr3:139814756-139904138 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026654
 protein coding gene Chr3:142359027-142458813 (-)
WSB/EiJ MGP_WSBEiJ_G0027182
 protein coding gene Chr3:145086970-145176517 (-)



Homology
more
  • Human Ortholog
    PKN2, protein kinase N2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PKN2, protein kinase N2
  • Synonyms
    Pak-2, PAK2, PRK2, PRKCL2, PRO2042, STK7
  • Links
    NCBI Gene ID: 5586
    neXtProt AC: NX_Q16513
    UniProt: Q16513

  • Chr Location
    1p22.2; chr1:88684222-88836255 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 3 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display embryonic lethality during organogenesis with impaired mesenchymal cell proliferation and neural crest cell migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    11
  • cDNA Data
    198
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109333 NCBI Gene Model | MGI Sequence Detail 91103 C57BL/6J ±  kb
    transcript NM_178654 RefSeq | MGI Sequence Detail 6207 ZRU/MplStud  
    polypeptide Q8BWW9 UniProt | EBI | MGI Sequence Detail 983 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 198
      cDNA 198

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-38255, MGI:1925929, MGI:2139749
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 12
      Phenotypes 21
    • Earliest
      J:36722 Quilliam LA, et al., Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling. J Biol Chem. 1996 Nov 15;271(46):28772-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory