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Ube2l3 Gene Detail
Summary
  • Symbol
    Ube2l3
  • Name
    ubiquitin-conjugating enzyme E2L 3
  • Synonyms
    Ubce7, UbcM4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109240
    NCBI Gene: 22195
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:16969879-17019363 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    783 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109240
 protein coding gene Chr16:16969877-17020513 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022573
 protein coding gene Chr16:14276825-14334125 (-)
A/J MGP_AJ_G0022534
 protein coding gene Chr16:13566947-13619169 (-)
AKR/J MGP_AKRJ_G0022511
 protein coding gene Chr16:14115827-14171637 (-)
BALB/cJ MGP_BALBcJ_G0022537
 protein coding gene Chr16:13716653-13768692 (-)
C3H/HeJ MGP_C3HHeJ_G0022304
 protein coding gene Chr16:14238785-14304411 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022988
 protein coding gene Chr16:14492559-14556043 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020508
 protein coding gene Chr16:13651583-13701564 (-)
CAST/EiJ MGP_CASTEiJ_G0021832
 protein coding gene Chr16:14153170-14207405 (-)
CBA/J MGP_CBAJ_G0022275
 protein coding gene Chr16:15162412-15233785 (-)
DBA/2J MGP_DBA2J_G0022405
 protein coding gene Chr16:13499643-13550997 (-)
FVB/NJ MGP_FVBNJ_G0022381
 protein coding gene Chr16:13534355-13590767 (-)
LP/J MGP_LPJ_G0022472
 protein coding gene Chr16:14047115-14098590 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022402
 protein coding gene Chr16:14862203-14920513 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022999
 protein coding gene Chr16:14036747-14100575 (-)
PWK/PhJ MGP_PWKPhJ_G0021575
 protein coding gene Chr16:13742441-13794583 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021403
 protein coding gene Chr16:14039392-14092813 (-)
WSB/EiJ MGP_WSBEiJ_G0021879
 protein coding gene Chr16:14042978-14100942 (-)



Homology
more
  • Human Ortholog
    UBE2L3, ubiquitin conjugating enzyme E2 L3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBE2L3, ubiquitin conjugating enzyme E2 L3
  • Synonyms
    E2-F1, L-UBC, UBCH7, UbcM4
  • Links
    NCBI Gene ID: 7332
    neXtProt AC: NX_P68036
    UniProt: P68036

  • Chr Location
    22q11.21; chr22:21549447-21624034 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A portion of hypomorphic embyros die before birth while those that survive are growth retarded and do not survive past the first day of life. The embryonic and perinatal lethality are attributed to defective placental development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    19
  • cDNA Data
    22
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22195 NCBI Gene Model | MGI Sequence Detail 49485 C57BL/6J ±  kb
    transcript NM_001419225 RefSeq | MGI Sequence Detail 3133 ZRU/MplStud  
    polypeptide P68037 UniProt | EBI | MGI Sequence Detail 154 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 8
      cDNA 22

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-38285, MGI:2146706
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 6
    • Earliest
      J:31581 Matuschewski K, et al., Identification of a novel family of ubiquitin-conjugating enzymes with distinct amino-terminal extensions. J Biol Chem. 1996 Feb 2;271(5):2789-94
    • Latest
      J:281603 Avagliano Trezza R, et al., Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome. Nat Neurosci. 2019 Aug;22(8):1235-1247
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory