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Vipr1 Gene Detail
Summary
  • Symbol
    Vipr1
  • Name
    vasoactive intestinal peptide receptor 1
  • Synonyms
    VIP-R1, VIP receptor subtype 1, VPAC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109272
    NCBI Gene: 22354
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:121471782-121502020 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 72.50 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    807 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109272
 protein coding gene Chr9:121471782-121502020 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035444
 protein coding gene Chr9:124585585-124621937 (+)
A/J MGP_AJ_G0035425
 protein coding gene Chr9:119848494-119878853 (+)
AKR/J MGP_AKRJ_G0035358
 protein coding gene Chr9:123038453-123071700 (+)
BALB/cJ MGP_BALBcJ_G0035421
 protein coding gene Chr9:119755020-119786354 (+)
C3H/HeJ MGP_C3HHeJ_G0035128
 protein coding gene Chr9:123497920-123530366 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035944
 protein coding gene Chr9:128000511-128036536 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032826
 protein coding gene Chr9:117010005-117040268 (+)
CAST/EiJ MGP_CASTEiJ_G0034433
 protein coding gene Chr9:123535515-123568611 (+)
CBA/J MGP_CBAJ_G0035096
 protein coding gene Chr9:132686220-132719189 (+)
DBA/2J MGP_DBA2J_G0035255
 protein coding gene Chr9:119288610-119318885 (+)
FVB/NJ MGP_FVBNJ_G0035202
 protein coding gene Chr9:118208681-118239551 (+)
LP/J MGP_LPJ_G0035334
 protein coding gene Chr9:124928247-124959414 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035243
 protein coding gene Chr9:133633290-133664530 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035963
 protein coding gene Chr9:123481739-123513433 (+)
PWK/PhJ MGP_PWKPhJ_G0034137
 protein coding gene Chr9:119750406-119782430 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033974
 protein coding gene Chr9:123596833-123628953 (+)
WSB/EiJ MGP_WSBEiJ_G0034553
 protein coding gene Chr9:123334811-123364994 (+)



Homology
more
  • Human Ortholog
    VIPR1, vasoactive intestinal peptide receptor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VIPR1, vasoactive intestinal peptide receptor 1
  • Synonyms
    HVR1, II, PACAP-R-2, PACAP-R2, RDC1, V1RG, VAPC1, VIPR, VIP-R-1, VIRG, VPAC1, VPAC1R, VPCAP1R
  • Links
    NCBI Gene ID: 7433
    neXtProt AC: NX_P32241
    UniProt: P32241

  • Chr Location
    3p22.1; chr3:42489299-42537573 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human VIPR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit prenatal lethality associated with severe neonatal growth failure, enlarged cecum, intestinal hemorrhage, and enterocyte hyperproliferation in addition to disorganized islets and impaired glucose homeostasisin surviving mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    6
  • cDNA Data
    8
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22354 NCBI Gene Model | MGI Sequence Detail 30239 C57BL/6J ±  kb
    transcript NM_011703 RefSeq | MGI Sequence Detail 4929 ZRU/MplStud  
    polypeptide P97751 UniProt | EBI | MGI Sequence Detail 459 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000017300 vasoactive intestinal polypeptide receptor 1
      (term hierarchy)
    • InterPro Domains
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR017981 GPCR, family 2-like, 7TM
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR001571 GPCR, family 2, vasoactive intestinal peptide receptor
      IPR001771 GPCR, family 2, vasoactive intestinal peptide receptor 1
      IPR050332 G-protein coupled receptor 2
    • GlyGen
      P97751 5 sites
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 9
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38317, MGI:2143260
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:36171 Delgado M, et al., Differential expression of vasoactive intestinal peptide receptors 1 and 2 (VIP-R1 and VIP-R2) mRNA in murine lymphocytes. J Neuroimmunol. 1996 Aug;68(1-2):27-38
    • Latest
      J:347570 Lei C, et al., Enteric VIP-producing neurons maintain gut microbiota homeostasis through regulating epithelium fucosylation. Cell Host Microbe. 2022 Oct 12;30(10):1417-1434.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory