Ogn MGI Mouse Gene Detail - MGI:109278

Symbol

Ogn
Name

osteoglycin
Synonyms

3110079A16Rik, mimecan, mimican, OG, SLRR3A

Feature Type

protein coding gene
IDs

MGI:109278
NCBI Gene: 18295
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr13:49761522-49777977 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 25.34 cM
Mapping Data

2 experiments

SNPs within 2kb

263 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109278	protein coding gene	Chr13:49761491-49777977 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020540	protein coding gene	Chr13:48587034-48603463 (+)
A/J	MGP_AJ_G0020494	protein coding gene	Chr13:46874456-46890884 (+)
AKR/J	MGP_AKRJ_G0020471	protein coding gene	Chr13:48192715-48209145 (+)
BALB/cJ	MGP_BALBcJ_G0020490	protein coding gene	Chr13:47079740-47096169 (+)
C3H/HeJ	MGP_C3HHeJ_G0020289	protein coding gene	Chr13:48007908-48024337 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020923	protein coding gene	Chr13:50051125-50067554 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018508	protein coding gene	Chr13:44830517-44847478 (+)
CAST/EiJ	MGP_CASTEiJ_G0019804	protein coding gene	Chr13:48026933-48043374 (+)
CBA/J	MGP_CBAJ_G0020250	protein coding gene	Chr13:52125062-52141489 (+)
DBA/2J	MGP_DBA2J_G0020372	protein coding gene	Chr13:46384840-46401269 (+)
FVB/NJ	MGP_FVBNJ_G0020351	protein coding gene	Chr13:45914630-45931059 (+)
LP/J	MGP_LPJ_G0020447	protein coding gene	Chr13:48807756-48824185 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020380	protein coding gene	Chr13:51832154-51851064 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020966	protein coding gene	Chr13:47880353-47896780 (+)
PWK/PhJ	MGP_PWKPhJ_G0019560	protein coding gene	Chr13:46574382-46591787 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019388	protein coding gene	Chr13:46588233-46604803 (+)
WSB/EiJ	MGP_WSBEiJ_G0019866	protein coding gene	Chr13:48209523-48225965 (+)

Human Ortholog

OGN, osteoglycin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OGN, osteoglycin
Synonyms

OG, OIF, SLRR3A
Links

HGNC:8126

NCBI Gene ID: 4969

neXtProt AC: NX_P20774

UniProt: P20774
Chr Location

9q22.31; chr9:92383268-92404699 (-) GRCh38

MGI Vertebrate Homology

Ogn stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: OGN
Gene Tree

Ogn

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Phenotype Summary

8 phenotypes from 3 alleles in 3 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

5
Targeted

5
Genomic Mutations

1 involving Ogn
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a disruption in this gene display reduced collagen fiber density and organization, as well as more variability in fibrilar diameter in both the skin and the cornea. Corneal clarity was unaffected whereas skin tensile strength was reduced.

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All GO Annotations

9
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1122
Tissues

70
cDNA Data

18
Literature Summary

22

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ogn

ZFIN ogna

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS26505.1

Ensembl

ENSMUSG00000021390 (Evidence)
NCBI Gene

18295

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021390	Ensembl Gene Model \| MGI Sequence Detail	16456	C57BL/6J	± kb
transcript	ENSMUST00000021822	Ensembl \| MGI Sequence Detail	2566	Not Applicable
polypeptide	ENSMUSP00000021822	Ensembl \| MGI Sequence Detail	298	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011617 mimecan

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR043547 Mimecan/Epiphycan/Opticin
GlyGen

Q62000 3 sites, 1 O-linked glycan (1 site)

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All nucleic 22

Genomic 1

cDNA 19

Primer pair 2

Microarray probesets 5

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MGD-MRK-38323, MGI:1920487

Summaries

All 74

Developmental Gene Expression 22

Gene Ontology 7

Phenotypes 19
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ogn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119719	Chr13:49761481-49761500 (+)	-31 bp
Tssr119720	Chr13:49761506-49761539 (+)	1 bp
Tssr119721	Chr13:49762509-49762520 (+)	993 bp
Tssr119722	Chr13:49762531-49762572 (+)	1,030 bp
Tssr119723	Chr13:49762575-49762589 (+)	1,060 bp
Tssr119724	Chr13:49762603-49762646 (+)	1,103 bp
Tssr119725	Chr13:49776377-49776389 (+)	14,861 bp
Tssr119726	Chr13:49776442-49776455 (+)	14,927 bp
Tssr119727	Chr13:49777005-49777010 (+)	15,486 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24